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The lessons of QUANTEC: recommendations for reporting and gathering data on dose-volume dependencies of treatment outcome.

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Title: The lessons of QUANTEC: recommendations for reporting and gathering data on dose-volume dependencies of treatment outcome.
Authors: Jackson A (AUTHOR), Marks LB (AUTHOR), Bentzen SM (AUTHOR), Eisbruch A (AUTHOR), Yorke ED (AUTHOR), Ten Haken RK (AUTHOR), Constine LS (AUTHOR), Deasy JO (AUTHOR), Jackson, Andrew1 (AUTHOR), Marks, Lawrence B (AUTHOR), Bentzen, Søren M (AUTHOR), Eisbruch, Avraham (AUTHOR), Yorke, Ellen D (AUTHOR), Ten Haken, Randal K (AUTHOR), Constine, Louis S (AUTHOR), Deasy, Joseph O (AUTHOR)
Source: International Journal of Radiation Oncology, Biology, Physics. Mar2010 Supplement, Vol. 76 Issue 3, pS155-60. 1p.
Subjects: Dose-response relationship (Radiation), Radiation injuries, Radiotherapy, Treatment effectiveness, Disease complications
Abstract: The 16 clinical articles in this issue review the dose-volume dependence of toxicities of external beam radiotherapy. They are limited by the difficulty of synthesizing results from different publications. The major problems stem from incomplete reporting of results and use of incompatible or ambiguous endpoints. Here we specify these problems; give recommendations to authors, editors, and reviewers on standards of reporting; and provide methods of defining endpoints suitable for the dose-volume analysis of toxicity. Adopting these recommendations will facilitate meta-analysis and increase the utility of individual studies of the dependence of complications on dose distributions. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
Description
Abstract:The 16 clinical articles in this issue review the dose-volume dependence of toxicities of external beam radiotherapy. They are limited by the difficulty of synthesizing results from different publications. The major problems stem from incomplete reporting of results and use of incompatible or ambiguous endpoints. Here we specify these problems; give recommendations to authors, editors, and reviewers on standards of reporting; and provide methods of defining endpoints suitable for the dose-volume analysis of toxicity. Adopting these recommendations will facilitate meta-analysis and increase the utility of individual studies of the dependence of complications on dose distributions. [ABSTRACT FROM AUTHOR]
ISSN:03603016
DOI:10.1016/j.ijrobp.2009.08.074