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Does joint alignment affect the T2 values of cartilage in patients with knee osteoarthritis?

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Title: Does joint alignment affect the T2 values of cartilage in patients with knee osteoarthritis?
Authors: Friedrich KM (AUTHOR), Shepard T (AUTHOR), Chang G (AUTHOR), Wang L (AUTHOR), Babb JS (AUTHOR), Schweitzer M (AUTHOR), Regatte R (AUTHOR), Friedrich, Klaus M1 (AUTHOR), Shepard, Timothy (AUTHOR), Chang, Gregory (AUTHOR), Wang, Ligong (AUTHOR), Babb, James S (AUTHOR), Schweitzer, Mark (AUTHOR), Regatte, Ravinder (AUTHOR)
Source: European Radiology. Jun2010, Vol. 20 Issue 6, p1532-1538. 7p.
Abstract: Objective: To assess the relationship between T2 values of femorotibial cartilage and knee alignment in patients with clinical symptoms of medial osteoarthritis (OA).Methods: Twenty-four patients (mean age +/- standard deviation, 62.5 +/- 9.9 years) with clinical symptoms of medial knee OA, 12 with varus and 12 with valgus alignment of the femorotibial joint, were investigated on 3T MR using a 2D multi-echo spin echo (MESE) sequence for T2 mapping. Analysis of covariance, Spearman correlation coefficients, exact Mann-Whitney tests, and Fisher's exact tests were used for statistical analysis.Results: Overall the T2 values of cartilage in the medial compartment (median +/- interquartile-range, 49.44 +/- 6.58) were significantly higher (P = 0.0043) than those in the lateral compartment (47.15 +/- 6.87). Patients with varus alignment (50.83 +/- 6.30 ms) had significantly higher T2 values of cartilage (P < 0.0001) than patients with valgus alignment (46.20 +/- 6.00 ms). No statistically significant association between the T2 values of cartilage (in either location) and the Kellgren Lawrence score was found in the varus or in the valgus group.Conclusion: T2 measurements were increased in medial knee OA patients with varus alignment, adding support to the theory of an association of OA and joint alignment. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Does joint alignment affect the T2 values of cartilage in patients with knee osteoarthritis?
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Friedrich+KM%22&quot;&gt;Friedrich KM&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shepard+T%22&quot;&gt;Shepard T&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chang+G%22&quot;&gt;Chang G&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wang+L%22&quot;&gt;Wang L&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Babb+JS%22&quot;&gt;Babb JS&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Schweitzer+M%22&quot;&gt;Schweitzer M&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Regatte+R%22&quot;&gt;Regatte R&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Friedrich%2C+Klaus+M%22&quot;&gt;Friedrich, Klaus M&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shepard%2C+Timothy%22&quot;&gt;Shepard, Timothy&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chang%2C+Gregory%22&quot;&gt;Chang, Gregory&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wang%2C+Ligong%22&quot;&gt;Wang, Ligong&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Babb%2C+James+S%22&quot;&gt;Babb, James S&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Schweitzer%2C+Mark%22&quot;&gt;Schweitzer, Mark&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Regatte%2C+Ravinder%22&quot;&gt;Regatte, Ravinder&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Radiology%22&quot;&gt;European Radiology&lt;/searchLink&gt;. Jun2010, Vol. 20 Issue 6, p1532-1538. 7p.
– Name: Abstract
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  Data: &lt;bold&gt;Objective: &lt;/bold&gt;To assess the relationship between T2 values of femorotibial cartilage and knee alignment in patients with clinical symptoms of medial osteoarthritis (OA).&lt;bold&gt;Methods: &lt;/bold&gt;Twenty-four patients (mean age +/- standard deviation, 62.5 +/- 9.9 years) with clinical symptoms of medial knee OA, 12 with varus and 12 with valgus alignment of the femorotibial joint, were investigated on 3T MR using a 2D multi-echo spin echo (MESE) sequence for T2 mapping. Analysis of covariance, Spearman correlation coefficients, exact Mann-Whitney tests, and Fisher&#39;s exact tests were used for statistical analysis.&lt;bold&gt;Results: &lt;/bold&gt;Overall the T2 values of cartilage in the medial compartment (median +/- interquartile-range, 49.44 +/- 6.58) were significantly higher (P = 0.0043) than those in the lateral compartment (47.15 +/- 6.87). Patients with varus alignment (50.83 +/- 6.30 ms) had significantly higher T2 values of cartilage (P &lt; 0.0001) than patients with valgus alignment (46.20 +/- 6.00 ms). No statistically significant association between the T2 values of cartilage (in either location) and the Kellgren Lawrence score was found in the varus or in the valgus group.&lt;bold&gt;Conclusion: &lt;/bold&gt;T2 measurements were increased in medial knee OA patients with varus alignment, adding support to the theory of an association of OA and joint alignment. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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