Diffusion-weighted MRI provides additional value to conventional dynamic contrast-enhanced MRI for detection of hepatocellular carcinoma.
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| Title: | Diffusion-weighted MRI provides additional value to conventional dynamic contrast-enhanced MRI for detection of hepatocellular carcinoma. |
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| Authors: | Vandecaveye V (AUTHOR), De Keyzer F (AUTHOR), Verslype C (AUTHOR), Op de Beeck K (AUTHOR), Komuta M (AUTHOR), Topal B (AUTHOR), Roebben I (AUTHOR), Bielen D (AUTHOR), Roskams T (AUTHOR), Nevens F (AUTHOR), Dymarkowski S (AUTHOR), Vandecaveye, Vincent1 (AUTHOR), De Keyzer, Frederik (AUTHOR), Verslype, Chris (AUTHOR), Op de Beeck, Katya (AUTHOR), Komuta, Mina (AUTHOR), Topal, Baki (AUTHOR), Roebben, Ilse (AUTHOR), Bielen, Didier (AUTHOR), Roskams, Tania (AUTHOR) |
| Source: | European Radiology. Oct2009, Vol. 19 Issue 10, p2456-2466. 11p. |
| Abstract: | The purpose of this study was to evaluate the accuracy of diffusion-weighted magnetic resonance imaging (DW-MRI) in differentiating HCC from benign cirrhotic lesions compared with conventional dynamic contrast-enhanced MRI. Fifty-five patients with cirrhosis underwent conventional and DW-MRI at 1.5 Tesla. Signal intensity ratios (SI(ratio)) of solid liver lesions to adjacent hepatic parenchyma were measured for b0, b100, b600 and b1000, and the apparent diffusion coefficients (ADC) were calculated. In 27 patients, imaging results were compared to histopathology, and in 28 patients, to imaging follow-up. Based on predetermined thresholds, sensitivity and specificity of DW-MRI and conventional MRI were compared. SI(ratio) was significantly different between malignant and benign lesions at all b-values (P < 0.0001). No significant difference in ADC was seen (P = 0.47). For detection of malignant lesions, DW-MRI with b600-SI(ratio) yielded a sensitivity of 95.2% compared to 80.6% for conventional MRI (P = 0.023) and a specificity of 82.7% compared to 65.4% (P = 0.064). The improved accuracy was most beneficial for differentiating malignant lesions smaller than 2 cm. DW-MRI with b600-SI(ratio) improved the detection of small HCC and the differentiation of pseudotumoral lesions compared with conventional MRI. [ABSTRACT FROM AUTHOR] |
| Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Items | – Name: Title Label: Title Group: Ti Data: Diffusion-weighted MRI provides additional value to conventional dynamic contrast-enhanced MRI for detection of hepatocellular carcinoma. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Vandecaveye+V%22">Vandecaveye V</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Keyzer+F%22">De Keyzer F</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Verslype+C%22">Verslype C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Op+de+Beeck+K%22">Op de Beeck K</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Komuta+M%22">Komuta M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Topal+B%22">Topal B</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Roebben+I%22">Roebben I</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bielen+D%22">Bielen D</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Roskams+T%22">Roskams T</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nevens+F%22">Nevens F</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dymarkowski+S%22">Dymarkowski S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vandecaveye%2C+Vincent%22">Vandecaveye, Vincent</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Keyzer%2C+Frederik%22">De Keyzer, Frederik</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Verslype%2C+Chris%22">Verslype, Chris</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Op+de+Beeck%2C+Katya%22">Op de Beeck, Katya</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Komuta%2C+Mina%22">Komuta, Mina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Topal%2C+Baki%22">Topal, Baki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Roebben%2C+Ilse%22">Roebben, Ilse</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bielen%2C+Didier%22">Bielen, Didier</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Roskams%2C+Tania%22">Roskams, Tania</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Oct2009, Vol. 19 Issue 10, p2456-2466. 11p. – Name: Abstract Label: Abstract Group: Ab Data: The purpose of this study was to evaluate the accuracy of diffusion-weighted magnetic resonance imaging (DW-MRI) in differentiating HCC from benign cirrhotic lesions compared with conventional dynamic contrast-enhanced MRI. Fifty-five patients with cirrhosis underwent conventional and DW-MRI at 1.5 Tesla. Signal intensity ratios (SI(ratio)) of solid liver lesions to adjacent hepatic parenchyma were measured for b0, b100, b600 and b1000, and the apparent diffusion coefficients (ADC) were calculated. In 27 patients, imaging results were compared to histopathology, and in 28 patients, to imaging follow-up. Based on predetermined thresholds, sensitivity and specificity of DW-MRI and conventional MRI were compared. SI(ratio) was significantly different between malignant and benign lesions at all b-values (P < 0.0001). No significant difference in ADC was seen (P = 0.47). For detection of malignant lesions, DW-MRI with b600-SI(ratio) yielded a sensitivity of 95.2% compared to 80.6% for conventional MRI (P = 0.023) and a specificity of 82.7% compared to 65.4% (P = 0.064). The improved accuracy was most beneficial for differentiating malignant lesions smaller than 2 cm. DW-MRI with b600-SI(ratio) improved the detection of small HCC and the differentiation of pseudotumoral lesions compared with conventional MRI. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00330-009-1431-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 2456 Titles: – TitleFull: Diffusion-weighted MRI provides additional value to conventional dynamic contrast-enhanced MRI for detection of hepatocellular carcinoma. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Vandecaveye V – PersonEntity: Name: NameFull: De Keyzer F – PersonEntity: Name: NameFull: Verslype C – PersonEntity: Name: NameFull: Op de Beeck K – PersonEntity: Name: NameFull: Komuta M – PersonEntity: Name: NameFull: Topal B – PersonEntity: Name: NameFull: Roebben I – PersonEntity: Name: NameFull: Bielen D – PersonEntity: Name: NameFull: Roskams T – PersonEntity: Name: NameFull: Nevens F – PersonEntity: Name: NameFull: Dymarkowski S – PersonEntity: Name: NameFull: Vandecaveye, Vincent – PersonEntity: Name: NameFull: De Keyzer, Frederik – PersonEntity: Name: NameFull: Verslype, Chris – PersonEntity: Name: NameFull: Op de Beeck, Katya – PersonEntity: Name: NameFull: Komuta, Mina – PersonEntity: Name: NameFull: Topal, Baki – PersonEntity: Name: NameFull: Roebben, Ilse – PersonEntity: Name: NameFull: Bielen, Didier – PersonEntity: Name: NameFull: Roskams, Tania IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2009 Type: published Y: 2009 Identifiers: – Type: issn-print Value: 09387994 Numbering: – Type: volume Value: 19 – Type: issue Value: 10 Titles: – TitleFull: European Radiology Type: main |
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