Dynamic contrast-enhanced and diffusion-weighted MRI for early detection of tumoral changes in single-dose and fractionated radiotherapy: evaluation in a rat rhabdomyosarcoma model.
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| Title: | Dynamic contrast-enhanced and diffusion-weighted MRI for early detection of tumoral changes in single-dose and fractionated radiotherapy: evaluation in a rat rhabdomyosarcoma model. |
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| Authors: | De Keyzer F (AUTHOR), Vandecaveye V (AUTHOR), Thoeny H (AUTHOR), Chen F (AUTHOR), Ni Y (AUTHOR), Marchal G (AUTHOR), Hermans R (AUTHOR), Nuyts S (AUTHOR), Landuyt W (AUTHOR), Bosmans H (AUTHOR), De Keyzer, F1 (AUTHOR), Vandecaveye, V (AUTHOR), Thoeny, H (AUTHOR), Chen, F (AUTHOR), Ni, Y (AUTHOR), Marchal, G (AUTHOR), Hermans, R (AUTHOR), Nuyts, S (AUTHOR), Landuyt, W (AUTHOR), Bosmans, H (AUTHOR) |
| Source: | European Radiology. Nov2009, Vol. 19 Issue 11, p2663-2671. 9p. |
| Abstract: | We aimed to examine different intratumoral changes after single-dose and fractionated radiotherapy, using diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) MRI in a rat rhabdomyosarcoma model. Four WAG/Rij rats with rhabdomyosarcomas in the flanks received single-dose radiotherapy of 8 Gy, and four others underwent fractionated radiotherapy (five times 3 Gy). In rats receiving single-dose radiotherapy, a significant perfusion decrease was found in the first 2 days post-treatment, with slow recuperation afterwards. No substantial diffusion changes could be seen; tumor growth delay was 12 days. The rats undergoing fractionated radiotherapy showed a similar perfusion decrease early after the treatment. However, a very strong increase in apparent diffusion coefficient occurred in the first 10 days; growth delay was 18 days. DW-MRI and DCE-MRI can be used to show early tumoral changes induced by radiotherapy. Single-dose and fractionated radiotherapy induce an immediate perfusion effect, while the latter induces more intratumoral necrosis. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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