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The use of acellular matrices for the tissue engineering of cardiac valves.

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Title: The use of acellular matrices for the tissue engineering of cardiac valves.
Authors: Knight RL (AUTHOR), Wilcox HE (AUTHOR), Korossis SA (AUTHOR), Fisher J (AUTHOR), Ingham E (AUTHOR), Knight, R L1 (AUTHOR), Wilcox, H E (AUTHOR), Korossis, S A (AUTHOR), Fisher, J (AUTHOR), Ingham, E (AUTHOR)
Source: Proceedings of the Institution of Mechanical Engineers -- Part H -- Journal of Engineering in Medicine (Professional Engineering Publishing). Jan2008, Vol. 222 Issue 1, p129-143. 15p.
Abstract: Tissue-engineering approaches to cardiac valve replacement have made considerable advances over recent years and it is likely that this application will realize clinical success in the near future. Research in this area has been driven by the inadequacy of the currently available cardiac valve prostheses for younger patients who require multiple reoperations as they grow and develop. Tissue engineering has the potential to provide a valve capable of the same growth, repair, and regeneration as a natural valve and could improve outcomes for patients of all ages. Owing to the function and physical environment of the cardiac valve, the development of tissue-engineered replacements is unusual in that the biomechanical properties of the construct must dominate the biological properties in order for the valve to be functional at the time of implantation. As a result of this, conventional tissue-engineering scaffolds based on biodegradable polymers or collagen may not at present be suitable in this situation because of their initial limited strength. Research into the use of acellular xenogeneic and allogeneic matrices for tissue-engineered heart valves has consequently become extremely popular since the biomechanical properties of the valve can potentially be preserved with an optimal decellularization technique that removes the cells without damaging the matrix. A number of acellular scaffolds have already been tested clinically both unseeded and preseeded with cells and these have met with variable results. This article reviews the concepts involved and the advantages and disadvantages of the different approaches to tissue engineering a living cardiac valve. [ABSTRACT FROM AUTHOR]
Copyright of Proceedings of the Institution of Mechanical Engineers -- Part H -- Journal of Engineering in Medicine (Professional Engineering Publishing) is the property of Professional Engineering Publishing and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
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PubType: Academic Journal
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  Data: The use of acellular matrices for the tissue engineering of cardiac valves.
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  Data: <searchLink fieldCode="AR" term="%22Knight+RL%22">Knight RL</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wilcox+HE%22">Wilcox HE</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Korossis+SA%22">Korossis SA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fisher+J%22">Fisher J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ingham+E%22">Ingham E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Knight%2C+R+L%22">Knight, R L</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wilcox%2C+H+E%22">Wilcox, H E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Korossis%2C+S+A%22">Korossis, S A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fisher%2C+J%22">Fisher, J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ingham%2C+E%22">Ingham, E</searchLink> (AUTHOR)
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Tissue-engineering approaches to cardiac valve replacement have made considerable advances over recent years and it is likely that this application will realize clinical success in the near future. Research in this area has been driven by the inadequacy of the currently available cardiac valve prostheses for younger patients who require multiple reoperations as they grow and develop. Tissue engineering has the potential to provide a valve capable of the same growth, repair, and regeneration as a natural valve and could improve outcomes for patients of all ages. Owing to the function and physical environment of the cardiac valve, the development of tissue-engineered replacements is unusual in that the biomechanical properties of the construct must dominate the biological properties in order for the valve to be functional at the time of implantation. As a result of this, conventional tissue-engineering scaffolds based on biodegradable polymers or collagen may not at present be suitable in this situation because of their initial limited strength. Research into the use of acellular xenogeneic and allogeneic matrices for tissue-engineered heart valves has consequently become extremely popular since the biomechanical properties of the valve can potentially be preserved with an optimal decellularization technique that removes the cells without damaging the matrix. A number of acellular scaffolds have already been tested clinically both unseeded and preseeded with cells and these have met with variable results. This article reviews the concepts involved and the advantages and disadvantages of the different approaches to tissue engineering a living cardiac valve. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Proceedings of the Institution of Mechanical Engineers -- Part H -- Journal of Engineering in Medicine (Professional Engineering Publishing) is the property of Professional Engineering Publishing and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Jan2008
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