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A DEMETER-like DNA demethylase governs tomato fruit ripening.

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Title: A DEMETER-like DNA demethylase governs tomato fruit ripening.
Authors: Ruie Liu1, How-Kit, Alexandre2, Stammitti, Linda1, Teyssier, Emeline1, Rolin, Dominique1, Mortain-Bertrand, Anne1, Halle, Stefanie1, Mingchun Liu3,4, Junhua Kong5, Chaoqun Wu5, Degraeve-Guibault, Charlotte1, Chapman, Natalie H.6, Maucourt, Mickael1, Hodgman, T. Charlie6, Tost, Jörg2,7, Bouzayen, Mondher3,4, Yiguo Hong5,8, Seymour, Graham B.7, Giovannoni, James J.9, Gallusci, Philippe1 philippe.gallusci@bordeaux.inra.fr
Source: Proceedings of the National Academy of Sciences of the United States of America. 8/24/2015, Vol. 112 Issue 34, p10804-10809. 6p.
Subjects: DNA methylation, Tomato breeding, Arabidopsis, DNA, Horticultural products
Abstract: In plants, genomic DNA methylation which contributes to development and stress responses can be actively removed by DEMETER-like DNA demethylases (DMLs). Indeed, in Arabidopsis DMLs are important formaternal imprinting and endosperm demethylation, but only a few studies demonstrate the developmental roles of active DNA demethylation conclusively in this plant. Here, we show a direct cause and effect relationship between active DNA demethylation mainly mediated by the tomato DML, SlDML2, and fruit ripening— an important developmental process unique to plants. RNAi SlDML2 knockdown results in ripening inhibition via hypermethylation and repression of the expression of genes encoding ripening transcription factors and rate-limiting enzymes of key biochemical processes such as carotenoid synthesis. Our data demonstrate that active DNA demethylation is central to the control of ripening in tomato. [ABSTRACT FROM AUTHOR]
Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 109111476
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: A DEMETER-like DNA demethylase governs tomato fruit ripening.
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  Data: <searchLink fieldCode="AR" term="%22Ruie+Liu%22">Ruie Liu</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22How-Kit%2C+Alexandre%22">How-Kit, Alexandre</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Stammitti%2C+Linda%22">Stammitti, Linda</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Teyssier%2C+Emeline%22">Teyssier, Emeline</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Rolin%2C+Dominique%22">Rolin, Dominique</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Mortain-Bertrand%2C+Anne%22">Mortain-Bertrand, Anne</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Halle%2C+Stefanie%22">Halle, Stefanie</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Mingchun+Liu%22">Mingchun Liu</searchLink><relatesTo>3,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Junhua+Kong%22">Junhua Kong</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Chaoqun+Wu%22">Chaoqun Wu</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Degraeve-Guibault%2C+Charlotte%22">Degraeve-Guibault, Charlotte</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Chapman%2C+Natalie+H%2E%22">Chapman, Natalie H.</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Maucourt%2C+Mickael%22">Maucourt, Mickael</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hodgman%2C+T%2E+Charlie%22">Hodgman, T. Charlie</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Tost%2C+Jörg%22">Tost, Jörg</searchLink><relatesTo>2,7</relatesTo><br /><searchLink fieldCode="AR" term="%22Bouzayen%2C+Mondher%22">Bouzayen, Mondher</searchLink><relatesTo>3,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Yiguo+Hong%22">Yiguo Hong</searchLink><relatesTo>5,8</relatesTo><br /><searchLink fieldCode="AR" term="%22Seymour%2C+Graham+B%2E%22">Seymour, Graham B.</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Giovannoni%2C+James+J%2E%22">Giovannoni, James J.</searchLink><relatesTo>9</relatesTo><br /><searchLink fieldCode="AR" term="%22Gallusci%2C+Philippe%22">Gallusci, Philippe</searchLink><relatesTo>1</relatesTo><i> philippe.gallusci@bordeaux.inra.fr</i>
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  Data: <searchLink fieldCode="JN" term="%22Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink>. 8/24/2015, Vol. 112 Issue 34, p10804-10809. 6p.
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  Data: <searchLink fieldCode="DE" term="%22DNA+methylation%22">DNA methylation</searchLink><br /><searchLink fieldCode="DE" term="%22Tomato+breeding%22">Tomato breeding</searchLink><br /><searchLink fieldCode="DE" term="%22Arabidopsis%22">Arabidopsis</searchLink><br /><searchLink fieldCode="DE" term="%22DNA%22">DNA</searchLink><br /><searchLink fieldCode="DE" term="%22Horticultural+products%22">Horticultural products</searchLink>
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  Data: In plants, genomic DNA methylation which contributes to development and stress responses can be actively removed by DEMETER-like DNA demethylases (DMLs). Indeed, in Arabidopsis DMLs are important formaternal imprinting and endosperm demethylation, but only a few studies demonstrate the developmental roles of active DNA demethylation conclusively in this plant. Here, we show a direct cause and effect relationship between active DNA demethylation mainly mediated by the tomato DML, SlDML2, and fruit ripening— an important developmental process unique to plants. RNAi SlDML2 knockdown results in ripening inhibition via hypermethylation and repression of the expression of genes encoding ripening transcription factors and rate-limiting enzymes of key biochemical processes such as carotenoid synthesis. Our data demonstrate that active DNA demethylation is central to the control of ripening in tomato. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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