A DEMETER-like DNA demethylase governs tomato fruit ripening.
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| Title: | A DEMETER-like DNA demethylase governs tomato fruit ripening. |
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| Authors: | Ruie Liu1, How-Kit, Alexandre2, Stammitti, Linda1, Teyssier, Emeline1, Rolin, Dominique1, Mortain-Bertrand, Anne1, Halle, Stefanie1, Mingchun Liu3,4, Junhua Kong5, Chaoqun Wu5, Degraeve-Guibault, Charlotte1, Chapman, Natalie H.6, Maucourt, Mickael1, Hodgman, T. Charlie6, Tost, Jörg2,7, Bouzayen, Mondher3,4, Yiguo Hong5,8, Seymour, Graham B.7, Giovannoni, James J.9, Gallusci, Philippe1 philippe.gallusci@bordeaux.inra.fr |
| Source: | Proceedings of the National Academy of Sciences of the United States of America. 8/24/2015, Vol. 112 Issue 34, p10804-10809. 6p. |
| Subjects: | DNA methylation, Tomato breeding, Arabidopsis, DNA, Horticultural products |
| Abstract: | In plants, genomic DNA methylation which contributes to development and stress responses can be actively removed by DEMETER-like DNA demethylases (DMLs). Indeed, in Arabidopsis DMLs are important formaternal imprinting and endosperm demethylation, but only a few studies demonstrate the developmental roles of active DNA demethylation conclusively in this plant. Here, we show a direct cause and effect relationship between active DNA demethylation mainly mediated by the tomato DML, SlDML2, and fruit ripening— an important developmental process unique to plants. RNAi SlDML2 knockdown results in ripening inhibition via hypermethylation and repression of the expression of genes encoding ripening transcription factors and rate-limiting enzymes of key biochemical processes such as carotenoid synthesis. Our data demonstrate that active DNA demethylation is central to the control of ripening in tomato. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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