Dissolution Parameters of Pu and Am after Inhalation Exposure of Rats to Different Amounts of Mixed (U, Pu)O2 or Industrial PuO2.
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| Title: | Dissolution Parameters of Pu and Am after Inhalation Exposure of Rats to Different Amounts of Mixed (U, Pu)O |
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| Authors: | GALL, B. RAMOUNET-LE1, FRITSCH, P.1 paul.fritsch@cea.fr, ABRAM, M.-C.1, GRILLON, G.1, RATEAU, G.1, DELFORGE, J.1 |
| Source: | Annals of Occupational Hygiene. 2002 Supplement, Vol. 46, p334-336. 3p. |
| Subjects: | Industrial hygiene, Atmospheric aerosols, Lung diseases, Dust diseases, Animal models in research |
| Abstract: | We have measured dissolution parameters of Pu and Am after inhalation exposure to industrial PuO2 or (U, Pu)O2 containing 5% Pu (MOX) aerosols for different initial deep lung deposits (IDLD) in four rat groups. The parameters are those described in the simplest dissolution model of ICRP66. The mean IDLD values were 1.7 and 3.7 κBq for PuO2 and 1.5 and 6.5 Bq for MOX. Although gross lung pathologies occurred in the highest IDLD groups, no significant difference in lung clearance parameters were observed as compared with the lowest IDLD groups. This was due to important individual variation. Dissolution parameters were obtained by a linear correlation analysis between individual lung cumulative deposits and transfer to blood, which was estimated from femur retention. Dissolution of Pu was significantly increased in the highest IDLD groups. In the case of PuO2 the main altered parameter was the fast dissolving fraction (fr), whereas in the case of MOX it was the dissolution rate of the slow dissolving fraction (ss). In both cases the difference corresponded to a factor of about 2. Preliminary results on Am dissolution suggested a similar response but with differences near a factor of 3. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 109118884 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Dissolution Parameters of Pu and Am after Inhalation Exposure of Rats to Different Amounts of Mixed (U, Pu)O<subscript>2</subscript> or Industrial PuO<subscript>2</subscript>. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22GALL%2C+B%2E+RAMOUNET-LE%22">GALL, B. RAMOUNET-LE</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22FRITSCH%2C+P%2E%22">FRITSCH, P.</searchLink><relatesTo>1</relatesTo><i> paul.fritsch@cea.fr</i><br /><searchLink fieldCode="AR" term="%22ABRAM%2C+M%2E-C%2E%22">ABRAM, M.-C.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22GRILLON%2C+G%2E%22">GRILLON, G.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22RATEAU%2C+G%2E%22">RATEAU, G.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22DELFORGE%2C+J%2E%22">DELFORGE, J.</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Occupational+Hygiene%22">Annals of Occupational Hygiene</searchLink>. 2002 Supplement, Vol. 46, p334-336. 3p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Industrial+hygiene%22">Industrial hygiene</searchLink><br /><searchLink fieldCode="DE" term="%22Atmospheric+aerosols%22">Atmospheric aerosols</searchLink><br /><searchLink fieldCode="DE" term="%22Lung+diseases%22">Lung diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Dust+diseases%22">Dust diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+models+in+research%22">Animal models in research</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: We have measured dissolution parameters of Pu and Am after inhalation exposure to industrial PuO2 or (U, Pu)O2 containing 5% Pu (MOX) aerosols for different initial deep lung deposits (IDLD) in four rat groups. The parameters are those described in the simplest dissolution model of ICRP66. The mean IDLD values were 1.7 and 3.7 κBq for PuO2 and 1.5 and 6.5 Bq for MOX. Although gross lung pathologies occurred in the highest IDLD groups, no significant difference in lung clearance parameters were observed as compared with the lowest IDLD groups. This was due to important individual variation. Dissolution parameters were obtained by a linear correlation analysis between individual lung cumulative deposits and transfer to blood, which was estimated from femur retention. Dissolution of Pu was significantly increased in the highest IDLD groups. In the case of PuO2 the main altered parameter was the fast dissolving fraction (fr), whereas in the case of MOX it was the dissolution rate of the slow dissolving fraction (ss). In both cases the difference corresponded to a factor of about 2. Preliminary results on Am dissolution suggested a similar response but with differences near a factor of 3. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1093/annhyg/46.suppl_1.334 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 3 StartPage: 334 Subjects: – SubjectFull: Industrial hygiene Type: general – SubjectFull: Atmospheric aerosols Type: general – SubjectFull: Lung diseases Type: general – SubjectFull: Dust diseases Type: general – SubjectFull: Animal models in research Type: general Titles: – TitleFull: Dissolution Parameters of Pu and Am after Inhalation Exposure of Rats to Different Amounts of Mixed (U, Pu)O2 or Industrial PuO2. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: GALL, B. RAMOUNET-LE – PersonEntity: Name: NameFull: FRITSCH, P. – PersonEntity: Name: NameFull: ABRAM, M.-C. – PersonEntity: Name: NameFull: GRILLON, G. – PersonEntity: Name: NameFull: RATEAU, G. – PersonEntity: Name: NameFull: DELFORGE, J. IsPartOfRelationships: – BibEntity: Dates: – D: 02 M: 03 Text: 2002 Supplement Type: published Y: 2002 Identifiers: – Type: issn-print Value: 00034878 Numbering: – Type: volume Value: 46 Titles: – TitleFull: Annals of Occupational Hygiene Type: main |
| ResultId | 1 |
