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Toenail Dust Particles: a Potential Inhalation Hazard to Podiatrists?

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Title: Toenail Dust Particles: a Potential Inhalation Hazard to Podiatrists?
Authors: DONALDSON, C. L.1, CARLINE, T.1, BROWN, D. M.2, GILMOUR, P. S.3, DONALDSON, K.2 k.donaldson@napier.ac.uk
Source: Annals of Occupational Hygiene. 2002 Supplement, Vol. 46, p365-368. 4p.
Subjects: Podiatrists, Endotoxins, Epithelial cells, Respiratory infections, Immune response
Abstract: Toenail dust collected from podiatrist's nail drills was examined for size, endotoxin content and ability to stimulate release of interleukin 8 (IL-8) from macrophages and lung epithelial cells in vitro. The size distribution revealed a large number of particles in the size ranges that would deposit in the nose, airways and lung periphery. Endotoxin was readily measurable in aqueous extracts of the nail particles and a soluble component of the nail dust particles was able to stimulate substantial release of IL-8 from epithelial cells. Suspensions of toenail particles were tested for ability to stimulate IL-8 release from monocyte-derived macrophages; treatment with polymyxin B to remove endotoxin had no effect. We conclude that podiatrists who routinely carry out nail drilling could be inhaling particles that can deposit throughout the respiratory tract, where they could contribute to inflammation by stimulating release of IL-8 from cells via the particles themselves and via endotoxin. [ABSTRACT FROM AUTHOR]
Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Toenail dust collected from podiatrist's nail drills was examined for size, endotoxin content and ability to stimulate release of interleukin 8 (IL-8) from macrophages and lung epithelial cells in vitro. The size distribution revealed a large number of particles in the size ranges that would deposit in the nose, airways and lung periphery. Endotoxin was readily measurable in aqueous extracts of the nail particles and a soluble component of the nail dust particles was able to stimulate substantial release of IL-8 from epithelial cells. Suspensions of toenail particles were tested for ability to stimulate IL-8 release from monocyte-derived macrophages; treatment with polymyxin B to remove endotoxin had no effect. We conclude that podiatrists who routinely carry out nail drilling could be inhaling particles that can deposit throughout the respiratory tract, where they could contribute to inflammation by stimulating release of IL-8 from cells via the particles themselves and via endotoxin. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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