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Lymph nodes in the irradiated field influence the yield of radiation-induced chromosomal aberrations in lymphocytes from breast cancer patients

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Title: Lymph nodes in the irradiated field influence the yield of radiation-induced chromosomal aberrations in lymphocytes from breast cancer patients
Authors: d'Alesio, Valentina1,2, Pacelli, Roberto3, Durante, Marco1,2 Marco.Durante@na.infn.it, Canale Cama, Gustavo4, Cella, Laura3, Gialanella, Giancarlo1,2, Grossi, Gianfranco1,2, Pugliese, Mariagabriella1,2, Punzo, Giorgio3, Sardi, Ilaria1, Scampoli, Paola1,2, Solla, Raffaele3, Salvatore, Marco4
Source: International Journal of Radiation Oncology, Biology, Physics. Nov2003, Vol. 57 Issue 3, p732-738. 7p.
Subjects: Chromosome abnormalities, Lymphocytes, Breast, Cancer, Antineoplastic agents, Breast tumors, Cisplatin, Combined modality therapy, Comparative studies, Surgical excision, Fluorouracil, Lymph nodes, Lymph node surgery, Research methodology, Medical cooperation, Methotrexate, Research, Lumpectomy, Evaluation research
Abstract: : PurposeTo measure chromosomal aberrations in blood lymphocytes from breast cancer patients treated with radiotherapy after quadrantectomy or tumorectomy.: Methods and materialsTwenty-two breast cancer patients treated with breast-conserving surgery and radiation were evaluated. Adjuvant chemotherapy was also given to 9 patients. Blood samples were obtained before radiotherapy, after about one-half of the fractions, and at the end of the treatment of the whole breast (50 Gy). Chromosome aberrations in peripheral blood lymphocytes were measured using chemical-induced premature chromosome condensation combined with fluorescence in situ hybridization.: ResultsRadiation treatment produced a significant increase in the yield of chromosomal aberrations. A large interindividual variability was observed. The variability was not related to field size, previous chemotherapy, or treatment morbidity. Chromosome aberrations in lymphocytes at the end of the treatment were significantly higher in the group of patients with no lymph nodes surgically removed before the treatment than in the group of patients with more than 10 lymph nodes removed.: ConclusionsThe number of lymph nodes within the radiation field is an important factor affecting the yield of radiation-induced chromosomal aberrations in breast cancer patients. [Copyright &y& Elsevier]
Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 10926534
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Label: Title
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  Data: Lymph nodes in the irradiated field influence the yield of radiation-induced chromosomal aberrations in lymphocytes from breast cancer patients
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  Data: <searchLink fieldCode="AR" term="%22d'Alesio%2C+Valentina%22">d'Alesio, Valentina</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Pacelli%2C+Roberto%22">Pacelli, Roberto</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Durante%2C+Marco%22">Durante, Marco</searchLink><relatesTo>1,2</relatesTo><i> Marco.Durante@na.infn.it</i><br /><searchLink fieldCode="AR" term="%22Canale+Cama%2C+Gustavo%22">Canale Cama, Gustavo</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Cella%2C+Laura%22">Cella, Laura</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Gialanella%2C+Giancarlo%22">Gialanella, Giancarlo</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Grossi%2C+Gianfranco%22">Grossi, Gianfranco</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Pugliese%2C+Mariagabriella%22">Pugliese, Mariagabriella</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Punzo%2C+Giorgio%22">Punzo, Giorgio</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Sardi%2C+Ilaria%22">Sardi, Ilaria</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Scampoli%2C+Paola%22">Scampoli, Paola</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Solla%2C+Raffaele%22">Solla, Raffaele</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Salvatore%2C+Marco%22">Salvatore, Marco</searchLink><relatesTo>4</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Radiation+Oncology%2C+Biology%2C+Physics%22">International Journal of Radiation Oncology, Biology, Physics</searchLink>. Nov2003, Vol. 57 Issue 3, p732-738. 7p.
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  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Chromosome+abnormalities%22">Chromosome abnormalities</searchLink><br /><searchLink fieldCode="DE" term="%22Lymphocytes%22">Lymphocytes</searchLink><br /><searchLink fieldCode="DE" term="%22Breast%22">Breast</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer%22">Cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Antineoplastic+agents%22">Antineoplastic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Breast+tumors%22">Breast tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Cisplatin%22">Cisplatin</searchLink><br /><searchLink fieldCode="DE" term="%22Combined+modality+therapy%22">Combined modality therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Surgical+excision%22">Surgical excision</searchLink><br /><searchLink fieldCode="DE" term="%22Fluorouracil%22">Fluorouracil</searchLink><br /><searchLink fieldCode="DE" term="%22Lymph+nodes%22">Lymph nodes</searchLink><br /><searchLink fieldCode="DE" term="%22Lymph+node+surgery%22">Lymph node surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Research+methodology%22">Research methodology</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+cooperation%22">Medical cooperation</searchLink><br /><searchLink fieldCode="DE" term="%22Methotrexate%22">Methotrexate</searchLink><br /><searchLink fieldCode="DE" term="%22Research%22">Research</searchLink><br /><searchLink fieldCode="DE" term="%22Lumpectomy%22">Lumpectomy</searchLink><br /><searchLink fieldCode="DE" term="%22Evaluation+research%22">Evaluation research</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: : PurposeTo measure chromosomal aberrations in blood lymphocytes from breast cancer patients treated with radiotherapy after quadrantectomy or tumorectomy.: Methods and materialsTwenty-two breast cancer patients treated with breast-conserving surgery and radiation were evaluated. Adjuvant chemotherapy was also given to 9 patients. Blood samples were obtained before radiotherapy, after about one-half of the fractions, and at the end of the treatment of the whole breast (50 Gy). Chromosome aberrations in peripheral blood lymphocytes were measured using chemical-induced premature chromosome condensation combined with fluorescence in situ hybridization.: ResultsRadiation treatment produced a significant increase in the yield of chromosomal aberrations. A large interindividual variability was observed. The variability was not related to field size, previous chemotherapy, or treatment morbidity. Chromosome aberrations in lymphocytes at the end of the treatment were significantly higher in the group of patients with no lymph nodes surgically removed before the treatment than in the group of patients with more than 10 lymph nodes removed.: ConclusionsThe number of lymph nodes within the radiation field is an important factor affecting the yield of radiation-induced chromosomal aberrations in breast cancer patients. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=10926534
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/S0360-3016(03)00664-3
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 732
    Subjects:
      – SubjectFull: Chromosome abnormalities
        Type: general
      – SubjectFull: Lymphocytes
        Type: general
      – SubjectFull: Breast
        Type: general
      – SubjectFull: Cancer
        Type: general
      – SubjectFull: Antineoplastic agents
        Type: general
      – SubjectFull: Breast tumors
        Type: general
      – SubjectFull: Cisplatin
        Type: general
      – SubjectFull: Combined modality therapy
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Surgical excision
        Type: general
      – SubjectFull: Fluorouracil
        Type: general
      – SubjectFull: Lymph nodes
        Type: general
      – SubjectFull: Lymph node surgery
        Type: general
      – SubjectFull: Research methodology
        Type: general
      – SubjectFull: Medical cooperation
        Type: general
      – SubjectFull: Methotrexate
        Type: general
      – SubjectFull: Research
        Type: general
      – SubjectFull: Lumpectomy
        Type: general
      – SubjectFull: Evaluation research
        Type: general
    Titles:
      – TitleFull: Lymph nodes in the irradiated field influence the yield of radiation-induced chromosomal aberrations in lymphocytes from breast cancer patients
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              Text: Nov2003
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              Y: 2003
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