Technical Note: A Monte Carlo study of magnetic-field-induced radiation dose effects in mice.
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| Title: | Technical Note: A Monte Carlo study of magnetic-field-induced radiation dose effects in mice. |
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| Authors: | Rubinstein, Ashley E.1, Liao, Zhongxing2, Melancon, Adam D.3, Guindani, Michele4, Followill, David S.3, Tailor, Ramesh C.3, Hazle, John D.5, Court, Laurence E.6 |
| Source: | Medical Physics. Sep2015, Vol. 42 Issue 9, p5510-5516. 7p. |
| Subjects: | Radiation doses, Magnetic resonance imaging, Laboratory mice, Medical imaging systems, Radiotherapy treatment planning |
| Abstract: | Purpose: Magnetic fields are known to alter radiation dose deposition. Before patients receive treatment using an MRI-linear accelerator (MRI-Linac), preclinical studies are needed to understand the biological consequences of magnetic-field-induced dose effects. In the present study, the authors sought to identify a beam energy and magnetic field strength combination suitable for preclinical murine experiments. Methods: Magnetic field dose effects were simulated in a mouse lung phantom using various beam energies (225 kVp, 350 kVp, 662 keV [Cs-137], 2 MV, and 1.25 MeV [Co-60]) and magnetic field strengths (0.75, 1.5, and 3 T). The resulting dose distributions were compared with those in a simulated human lung phantom irradiated with a 6 or 8MVbeam and orthogonal 1.5 T magnetic field. Results: In the human lung phantom, the authors observed a dose increase of 45% and 54% at the soft-tissue-to-lung interface and a dose decrease of 41% and 48% at the lung-to-soft-tissue interface for the 6 and 8 MV beams, respectively. In the mouse simulations, the magnetic fields had no measurable effect on the 225 or 350 kVp dose distribution. The dose increases with the Cs-137 beam for the 0.75, 1.5, and 3 T magnetic fields were 9%, 29%, and 42%, respectively. The dose decreases were 9%, 21%, and 37%. For the 2 MV beam, the dose increases were 16%, 33%, and 31% and the dose decreases were 9%, 19%, and 30%. For the Co-60 beam, the dose increases were 19%, 54%, and 44%, and the dose decreases were 19%, 42%, and 40%. Conclusions: The magnetic field dose effects in the mouse phantom using a Cs-137, 3 T combination or a Co-60, 1.5 or 3 T combination most closely resemble those in simulated human treatments with a 6 MV, 1.5 T MRI-Linac. The effects with a Co-60, 1.5 T combination most closely resemble those in simulated human treatments with an 8 MV, 1.5 T MRI-Linac. [ABSTRACT FROM AUTHOR] |
| Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 109330554 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Technical Note: A Monte Carlo study of magnetic-field-induced radiation dose effects in mice. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Rubinstein%2C+Ashley+E%2E%22">Rubinstein, Ashley E.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Liao%2C+Zhongxing%22">Liao, Zhongxing</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Melancon%2C+Adam+D%2E%22">Melancon, Adam D.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Guindani%2C+Michele%22">Guindani, Michele</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Followill%2C+David+S%2E%22">Followill, David S.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Tailor%2C+Ramesh+C%2E%22">Tailor, Ramesh C.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Hazle%2C+John+D%2E%22">Hazle, John D.</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Court%2C+Laurence+E%2E%22">Court, Laurence E.</searchLink><relatesTo>6</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Medical+Physics%22">Medical Physics</searchLink>. Sep2015, Vol. 42 Issue 9, p5510-5516. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Radiation+doses%22">Radiation doses</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+mice%22">Laboratory mice</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+imaging+systems%22">Medical imaging systems</searchLink><br /><searchLink fieldCode="DE" term="%22Radiotherapy+treatment+planning%22">Radiotherapy treatment planning</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: Magnetic fields are known to alter radiation dose deposition. Before patients receive treatment using an MRI-linear accelerator (MRI-Linac), preclinical studies are needed to understand the biological consequences of magnetic-field-induced dose effects. In the present study, the authors sought to identify a beam energy and magnetic field strength combination suitable for preclinical murine experiments. Methods: Magnetic field dose effects were simulated in a mouse lung phantom using various beam energies (225 kVp, 350 kVp, 662 keV [Cs-137], 2 MV, and 1.25 MeV [Co-60]) and magnetic field strengths (0.75, 1.5, and 3 T). The resulting dose distributions were compared with those in a simulated human lung phantom irradiated with a 6 or 8MVbeam and orthogonal 1.5 T magnetic field. Results: In the human lung phantom, the authors observed a dose increase of 45% and 54% at the soft-tissue-to-lung interface and a dose decrease of 41% and 48% at the lung-to-soft-tissue interface for the 6 and 8 MV beams, respectively. In the mouse simulations, the magnetic fields had no measurable effect on the 225 or 350 kVp dose distribution. The dose increases with the Cs-137 beam for the 0.75, 1.5, and 3 T magnetic fields were 9%, 29%, and 42%, respectively. The dose decreases were 9%, 21%, and 37%. For the 2 MV beam, the dose increases were 16%, 33%, and 31% and the dose decreases were 9%, 19%, and 30%. For the Co-60 beam, the dose increases were 19%, 54%, and 44%, and the dose decreases were 19%, 42%, and 40%. Conclusions: The magnetic field dose effects in the mouse phantom using a Cs-137, 3 T combination or a Co-60, 1.5 or 3 T combination most closely resemble those in simulated human treatments with a 6 MV, 1.5 T MRI-Linac. The effects with a Co-60, 1.5 T combination most closely resemble those in simulated human treatments with an 8 MV, 1.5 T MRI-Linac. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1118/1.4928600 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 5510 Subjects: – SubjectFull: Radiation doses Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Laboratory mice Type: general – SubjectFull: Medical imaging systems Type: general – SubjectFull: Radiotherapy treatment planning Type: general Titles: – TitleFull: Technical Note: A Monte Carlo study of magnetic-field-induced radiation dose effects in mice. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rubinstein, Ashley E. – PersonEntity: Name: NameFull: Liao, Zhongxing – PersonEntity: Name: NameFull: Melancon, Adam D. – PersonEntity: Name: NameFull: Guindani, Michele – PersonEntity: Name: NameFull: Followill, David S. – PersonEntity: Name: NameFull: Tailor, Ramesh C. – PersonEntity: Name: NameFull: Hazle, John D. – PersonEntity: Name: NameFull: Court, Laurence E. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2015 Type: published Y: 2015 Identifiers: – Type: issn-print Value: 00942405 Numbering: – Type: volume Value: 42 – Type: issue Value: 9 Titles: – TitleFull: Medical Physics Type: main |
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