Antibiotic-loaded polypropylene surgical meshes with suitable biological behaviour by plasma functionalization and polymerization.
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| Title: | Antibiotic-loaded polypropylene surgical meshes with suitable biological behaviour by plasma functionalization and polymerization. |
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| Authors: | Labay, C.1,2, Canal, J.M.1, Modic, M.3, Cvelbar, U.3, Quiles, M.4, Armengol, M.4, Arbos, M.A.4, Gil, F.J.2, Canal, C.2 cristina.canal@upc.edu |
| Source: | Biomaterials. Dec2015, Vol. 71, p132-144. 13p. |
| Subjects: | Polypropylene, Surgical meshes, Antibiotics, Polymerization, Hernia surgery, Surgical complications, Artificial implants |
| Abstract: | Hernia repair is one of the most common operations in general surgery, and its associated complications typically relate to infections, among others. The loading of antibiotics to surgical meshes to deliver them locally in the abdominal hernia repair site can be one way to manage infections associated with surgical implants. However, the amount of drug loaded is restricted by the low wettability of polypropylene (PP). In this work, plasma has been used to tailor the surface properties of PP meshes to obtain high loading of ampicillin while conserving the desired biological properties of the unmodified samples and conferring them with antibacterial activity. It was demonstrated that the new surface chemistry and improved wettability led to 3-fold higher antibiotic loading. Subsequently, a PEG-like dry coating was deposited from tetraglyme with low-pressure plasma which allowed maintaining the high drug loading and kept cell properties such as chemotaxis, adhesion and morphology to the same levels as the untreated ones which have shown long-standing clinical success. [ABSTRACT FROM AUTHOR] |
| Copyright of Biomaterials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 109446091 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Antibiotic-loaded polypropylene surgical meshes with suitable biological behaviour by plasma functionalization and polymerization. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Labay%2C+C%2E%22">Labay, C.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Canal%2C+J%2EM%2E%22">Canal, J.M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Modic%2C+M%2E%22">Modic, M.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Cvelbar%2C+U%2E%22">Cvelbar, U.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Quiles%2C+M%2E%22">Quiles, M.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Armengol%2C+M%2E%22">Armengol, M.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Arbos%2C+M%2EA%2E%22">Arbos, M.A.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Gil%2C+F%2EJ%2E%22">Gil, F.J.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Canal%2C+C%2E%22">Canal, C.</searchLink><relatesTo>2</relatesTo><i> cristina.canal@upc.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Biomaterials%22">Biomaterials</searchLink>. Dec2015, Vol. 71, p132-144. 13p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Polypropylene%22">Polypropylene</searchLink><br /><searchLink fieldCode="DE" term="%22Surgical+meshes%22">Surgical meshes</searchLink><br /><searchLink fieldCode="DE" term="%22Antibiotics%22">Antibiotics</searchLink><br /><searchLink fieldCode="DE" term="%22Polymerization%22">Polymerization</searchLink><br /><searchLink fieldCode="DE" term="%22Hernia+surgery%22">Hernia surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Surgical+complications%22">Surgical complications</searchLink><br /><searchLink fieldCode="DE" term="%22Artificial+implants%22">Artificial implants</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Hernia repair is one of the most common operations in general surgery, and its associated complications typically relate to infections, among others. The loading of antibiotics to surgical meshes to deliver them locally in the abdominal hernia repair site can be one way to manage infections associated with surgical implants. However, the amount of drug loaded is restricted by the low wettability of polypropylene (PP). In this work, plasma has been used to tailor the surface properties of PP meshes to obtain high loading of ampicillin while conserving the desired biological properties of the unmodified samples and conferring them with antibacterial activity. It was demonstrated that the new surface chemistry and improved wettability led to 3-fold higher antibiotic loading. Subsequently, a PEG-like dry coating was deposited from tetraglyme with low-pressure plasma which allowed maintaining the high drug loading and kept cell properties such as chemotaxis, adhesion and morphology to the same levels as the untreated ones which have shown long-standing clinical success. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Biomaterials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.biomaterials.2015.08.023 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 132 Subjects: – SubjectFull: Polypropylene Type: general – SubjectFull: Surgical meshes Type: general – SubjectFull: Antibiotics Type: general – SubjectFull: Polymerization Type: general – SubjectFull: Hernia surgery Type: general – SubjectFull: Surgical complications Type: general – SubjectFull: Artificial implants Type: general Titles: – TitleFull: Antibiotic-loaded polypropylene surgical meshes with suitable biological behaviour by plasma functionalization and polymerization. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Labay, C. – PersonEntity: Name: NameFull: Canal, J.M. – PersonEntity: Name: NameFull: Modic, M. – PersonEntity: Name: NameFull: Cvelbar, U. – PersonEntity: Name: NameFull: Quiles, M. – PersonEntity: Name: NameFull: Armengol, M. – PersonEntity: Name: NameFull: Arbos, M.A. – PersonEntity: Name: NameFull: Gil, F.J. – PersonEntity: Name: NameFull: Canal, C. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2015 Type: published Y: 2015 Identifiers: – Type: issn-print Value: 01429612 Numbering: – Type: volume Value: 71 Titles: – TitleFull: Biomaterials Type: main |
| ResultId | 1 |
