In vitro degradation studies and mechanical behavior of poly(ε-caprolactone-co-δ-valerolactone) and poly(ε-caprolactone-co-L-lactide) with random and semi-alternating chain microstructures.
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| Title: | In vitro degradation studies and mechanical behavior of poly(ε-caprolactone-co-δ-valerolactone) and poly(ε-caprolactone-co-L-lactide) with random and semi-alternating chain microstructures. |
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| Authors: | Fernández, Jorge1 jorge.fernandez@ehu.es, Etxeberria, Agustin2, Sarasua, Jose-Ramon1 |
| Source: | European Polymer Journal. Oct2015, Vol. 71, p585-595. 11p. |
| Subjects: | Biodegradation, Polymers, Polycaprolactone, Biomedical engineering, Hydrolysis, Homopolymerizations, Glass transitions |
| Abstract: | Poly(ε-caprolactone) (PCL) is one of the most common polymers employed in the biomedical field owing to its outstanding properties, however, it degrades slowly, at a rate ( K Mw ) of 0.0010 days −1 at 37 °C. The incorporation of a second comonomer and the tailoring of more disordered chain microstructures were tested to accelerate hydrolysis. Both ε-caprolactone-co-δ-valerolactone and ε-caprolactone-co- L -lactide copolymers, synthesized with random ( R ∼ 1) and semi-alternating ( R → 2) distribution of sequences, exhibited faster degradation rates than PCL. ε-CL-co-δ-VAL, with ε-CL molar contents ranging from 76% to 85%, possessed K Mw values of between 0.0052 and 0.0033 days −1 , whereas the copolymers based on lactide, with 88–94% of ε-CL, had a K Mw 6–10 times higher than that of the homopolymer. The crystalline phase played a pivotal role in water absorption and degradation process, but was also responsible for the mechanical behavior of these low glass transition temperature polymers. At 21 °C all the copolymers showed excellent ductility (strain at break > 1000%) and improved flexibility compared to PCL (with secant modulus between 56 and 185 MPa). At body temperature (37 °C) it was only possible to measure the properties of the copolymers which had a T m above 52 °C or a high enough melting enthalpy (>33 J g −1 ). Moreover, at this temperature, PCL and the ε-CL-co- L -LA with a ε-CL content higher than 88% exhibited lower stress related properties. Nevertheless, the mechanical performance at both temperatures of these poly(ε-CL-co- L -LA), in addition to their upgraded biodegradability, make them potential substitutes for PCL. [ABSTRACT FROM AUTHOR] |
| Copyright of European Polymer Journal is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 109553305 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: In vitro degradation studies and mechanical behavior of poly(ε-caprolactone-co-δ-valerolactone) and poly(ε-caprolactone-co-L-lactide) with random and semi-alternating chain microstructures. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Fernández%2C+Jorge%22">Fernández, Jorge</searchLink><relatesTo>1</relatesTo><i> jorge.fernandez@ehu.es</i><br /><searchLink fieldCode="AR" term="%22Etxeberria%2C+Agustin%22">Etxeberria, Agustin</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Sarasua%2C+Jose-Ramon%22">Sarasua, Jose-Ramon</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Polymer+Journal%22">European Polymer Journal</searchLink>. Oct2015, Vol. 71, p585-595. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Biodegradation%22">Biodegradation</searchLink><br /><searchLink fieldCode="DE" term="%22Polymers%22">Polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Polycaprolactone%22">Polycaprolactone</searchLink><br /><searchLink fieldCode="DE" term="%22Biomedical+engineering%22">Biomedical engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrolysis%22">Hydrolysis</searchLink><br /><searchLink fieldCode="DE" term="%22Homopolymerizations%22">Homopolymerizations</searchLink><br /><searchLink fieldCode="DE" term="%22Glass+transitions%22">Glass transitions</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Poly(ε-caprolactone) (PCL) is one of the most common polymers employed in the biomedical field owing to its outstanding properties, however, it degrades slowly, at a rate ( K Mw ) of 0.0010 days −1 at 37 °C. The incorporation of a second comonomer and the tailoring of more disordered chain microstructures were tested to accelerate hydrolysis. Both ε-caprolactone-co-δ-valerolactone and ε-caprolactone-co- L -lactide copolymers, synthesized with random ( R ∼ 1) and semi-alternating ( R → 2) distribution of sequences, exhibited faster degradation rates than PCL. ε-CL-co-δ-VAL, with ε-CL molar contents ranging from 76% to 85%, possessed K Mw values of between 0.0052 and 0.0033 days −1 , whereas the copolymers based on lactide, with 88–94% of ε-CL, had a K Mw 6–10 times higher than that of the homopolymer. The crystalline phase played a pivotal role in water absorption and degradation process, but was also responsible for the mechanical behavior of these low glass transition temperature polymers. At 21 °C all the copolymers showed excellent ductility (strain at break > 1000%) and improved flexibility compared to PCL (with secant modulus between 56 and 185 MPa). At body temperature (37 °C) it was only possible to measure the properties of the copolymers which had a T m above 52 °C or a high enough melting enthalpy (>33 J g −1 ). Moreover, at this temperature, PCL and the ε-CL-co- L -LA with a ε-CL content higher than 88% exhibited lower stress related properties. Nevertheless, the mechanical performance at both temperatures of these poly(ε-CL-co- L -LA), in addition to their upgraded biodegradability, make them potential substitutes for PCL. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Polymer Journal is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.eurpolymj.2015.09.001 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 585 Subjects: – SubjectFull: Biodegradation Type: general – SubjectFull: Polymers Type: general – SubjectFull: Polycaprolactone Type: general – SubjectFull: Biomedical engineering Type: general – SubjectFull: Hydrolysis Type: general – SubjectFull: Homopolymerizations Type: general – SubjectFull: Glass transitions Type: general Titles: – TitleFull: In vitro degradation studies and mechanical behavior of poly(ε-caprolactone-co-δ-valerolactone) and poly(ε-caprolactone-co-L-lactide) with random and semi-alternating chain microstructures. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fernández, Jorge – PersonEntity: Name: NameFull: Etxeberria, Agustin – PersonEntity: Name: NameFull: Sarasua, Jose-Ramon IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2015 Type: published Y: 2015 Identifiers: – Type: issn-print Value: 00143057 Numbering: – Type: volume Value: 71 Titles: – TitleFull: European Polymer Journal Type: main |
| ResultId | 1 |
