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Diffusion-weighted MRI for uveal melanoma liver metastasis detection.

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Title: Diffusion-weighted MRI for uveal melanoma liver metastasis detection.
Authors: Wagner, Mathilde (AUTHOR), Mariani, Pascale (AUTHOR), Bidard, François Clément (AUTHOR), Rodrigues, Manuel Jorge (AUTHOR), Farkhondeh, Fereshteh (AUTHOR), Cassoux, Nathalie (AUTHOR), Piperno-Neumann, Sophie (AUTHOR), Petras, Slavomir (AUTHOR), Servois, Vincent (AUTHOR)
Source: European Radiology. Aug2015, Vol. 25 Issue 8, p2263-2273. 11p.
Subjects: Chemical elements, Diagnostic imaging, Liver tumors, Longitudinal method, Magnetic resonance imaging, Computers in medicine, Melanoma, Uvea, Contrast media, Retrospective studies, Diagnosis, Tumors
Abstract: Objectives: We aimed to assess the sensitivity of diffusion-weighted (DW) magnetic resonance (MR) imaging for the detection of pathologically confirmed uveal melanoma liver metastases (UMLM).Methods: Twenty patients who underwent complete surgical resection of their UMLM (N = 83) were included. Pre-surgery liver MR imaging included T2-weighted, T1-weighted, DW and dynamic-gadolinium-enhanced MR sequences. Two radiologists independently reviewed three sets of images (DW / morphologic-dynamic / combined) for each patient using intraoperative and pathological findings as a standard of reference.Results: The sensitivities of the morphologic-dynamic and DW images for UMLM detection were 63 % and 59 %, respectively, for reader #1 (R1) and 64 % and 53 %, for reader #2 (R2). Sensitivity of the combined set was higher than sensitivity in the two other sets (R1:69 %, R2:67 %), but was only significantly different than the sensitivity of the DW images (McNemar test). For the three sets and the two readers, the sensitivity for UMLM smaller than 5 mm (37-46 %) was significantly lower than that for UMLM larger than 5 mm (67-90 %). The sensitivity for UMLM located in the subcapsular area (41-54 %) was significantly lower than that for intraparenchymal UMLM (68-86 %) (Chi-square test).Conclusion: Our study shows that the addition of DW imaging to morphologic-dynamic images does not significantly increase MR sensitivities for UMLM detection.Key Points: • The MR imaging sensitivity for uveal melanoma liver metastases (UMLM) was 69 %. • Addition of DW imaging to morphologic-dynamic images does not increase sensitivity significantly. • Sensitivity for subcapsular UMLM was significantly lower than sensitivity for intraparenchymal UMLM. • The T2 shortening effect does not appear to influence lesion detection in DWI. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Diffusion-weighted MRI for uveal melanoma liver metastasis detection.
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  Data: <searchLink fieldCode="AR" term="%22Wagner%2C+Mathilde%22">Wagner, Mathilde</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mariani%2C+Pascale%22">Mariani, Pascale</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bidard%2C+François+Clément%22">Bidard, François Clément</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rodrigues%2C+Manuel+Jorge%22">Rodrigues, Manuel Jorge</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Farkhondeh%2C+Fereshteh%22">Farkhondeh, Fereshteh</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cassoux%2C+Nathalie%22">Cassoux, Nathalie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Piperno-Neumann%2C+Sophie%22">Piperno-Neumann, Sophie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Petras%2C+Slavomir%22">Petras, Slavomir</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Servois%2C+Vincent%22">Servois, Vincent</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Aug2015, Vol. 25 Issue 8, p2263-2273. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Chemical+elements%22">Chemical elements</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnostic+imaging%22">Diagnostic imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Liver+tumors%22">Liver tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Computers+in+medicine%22">Computers in medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Melanoma%22">Melanoma</searchLink><br /><searchLink fieldCode="DE" term="%22Uvea%22">Uvea</searchLink><br /><searchLink fieldCode="DE" term="%22Contrast+media%22">Contrast media</searchLink><br /><searchLink fieldCode="DE" term="%22Retrospective+studies%22">Retrospective studies</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis%22">Diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Tumors%22">Tumors</searchLink>
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  Data: <bold>Objectives: </bold>We aimed to assess the sensitivity of diffusion-weighted (DW) magnetic resonance (MR) imaging for the detection of pathologically confirmed uveal melanoma liver metastases (UMLM).<bold>Methods: </bold>Twenty patients who underwent complete surgical resection of their UMLM (N = 83) were included. Pre-surgery liver MR imaging included T2-weighted, T1-weighted, DW and dynamic-gadolinium-enhanced MR sequences. Two radiologists independently reviewed three sets of images (DW / morphologic-dynamic / combined) for each patient using intraoperative and pathological findings as a standard of reference.<bold>Results: </bold>The sensitivities of the morphologic-dynamic and DW images for UMLM detection were 63 % and 59 %, respectively, for reader #1 (R1) and 64 % and 53 %, for reader #2 (R2). Sensitivity of the combined set was higher than sensitivity in the two other sets (R1:69 %, R2:67 %), but was only significantly different than the sensitivity of the DW images (McNemar test). For the three sets and the two readers, the sensitivity for UMLM smaller than 5 mm (37-46 %) was significantly lower than that for UMLM larger than 5 mm (67-90 %). The sensitivity for UMLM located in the subcapsular area (41-54 %) was significantly lower than that for intraparenchymal UMLM (68-86 %) (Chi-square test).<bold>Conclusion: </bold>Our study shows that the addition of DW imaging to morphologic-dynamic images does not significantly increase MR sensitivities for UMLM detection.<bold>Key Points: </bold>• The MR imaging sensitivity for uveal melanoma liver metastases (UMLM) was 69 %. • Addition of DW imaging to morphologic-dynamic images does not increase sensitivity significantly. • Sensitivity for subcapsular UMLM was significantly lower than sensitivity for intraparenchymal UMLM. • The T2 shortening effect does not appear to influence lesion detection in DWI. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00330-015-3662-y
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        Text: English
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      – SubjectFull: Liver tumors
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