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Diffusion-weighted MRI for uveal melanoma liver metastasis detection.

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Title:	Diffusion-weighted MRI for uveal melanoma liver metastasis detection.
Authors:	Wagner, Mathilde (AUTHOR), Mariani, Pascale (AUTHOR), Bidard, François Clément (AUTHOR), Rodrigues, Manuel Jorge (AUTHOR), Farkhondeh, Fereshteh (AUTHOR), Cassoux, Nathalie (AUTHOR), Piperno-Neumann, Sophie (AUTHOR), Petras, Slavomir (AUTHOR), Servois, Vincent (AUTHOR)
Source:	European Radiology. Aug2015, Vol. 25 Issue 8, p2263-2273. 11p.
Subjects:	Chemical elements, Diagnostic imaging, Liver tumors, Longitudinal method, Magnetic resonance imaging, Computers in medicine, Melanoma, Uvea, Contrast media, Retrospective studies, Diagnosis, Tumors
Abstract:	Objectives: We aimed to assess the sensitivity of diffusion-weighted (DW) magnetic resonance (MR) imaging for the detection of pathologically confirmed uveal melanoma liver metastases (UMLM).Methods: Twenty patients who underwent complete surgical resection of their UMLM (N = 83) were included. Pre-surgery liver MR imaging included T2-weighted, T1-weighted, DW and dynamic-gadolinium-enhanced MR sequences. Two radiologists independently reviewed three sets of images (DW / morphologic-dynamic / combined) for each patient using intraoperative and pathological findings as a standard of reference.Results: The sensitivities of the morphologic-dynamic and DW images for UMLM detection were 63 % and 59 %, respectively, for reader #1 (R1) and 64 % and 53 %, for reader #2 (R2). Sensitivity of the combined set was higher than sensitivity in the two other sets (R1:69 %, R2:67 %), but was only significantly different than the sensitivity of the DW images (McNemar test). For the three sets and the two readers, the sensitivity for UMLM smaller than 5 mm (37-46 %) was significantly lower than that for UMLM larger than 5 mm (67-90 %). The sensitivity for UMLM located in the subcapsular area (41-54 %) was significantly lower than that for intraparenchymal UMLM (68-86 %) (Chi-square test).Conclusion: Our study shows that the addition of DW imaging to morphologic-dynamic images does not significantly increase MR sensitivities for UMLM detection.Key Points: • The MR imaging sensitivity for uveal melanoma liver metastases (UMLM) was 69 %. • Addition of DW imaging to morphologic-dynamic images does not increase sensitivity significantly. • Sensitivity for subcapsular UMLM was significantly lower than sensitivity for intraparenchymal UMLM. • The T2 shortening effect does not appear to influence lesion detection in DWI. [ABSTRACT FROM AUTHOR]
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Database:	Engineering Source
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