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Urinary biomarkers of exposure and of oxidative damage in children exposed to low airborne concentrations of benzene.

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Title: Urinary biomarkers of exposure and of oxidative damage in children exposed to low airborne concentrations of benzene.
Authors: Andreoli, R.1 roberta.andreoli@unipr.it, Spatari, G.2, Pigini, D.3, Poli, D.3, Banda, I.1, Goldoni, M.1, Riccelli, M.G.1, Petyx, M.4, Protano, C.5, Vitali, M.5, Barbaro, M.2, Mutti, A.1
Source: Environmental Research. Oct2015, Vol. 142, p264-272. 9p.
Subjects: Biomarkers, Urinary organ physiology, Benzene analysis, Juvenile diseases, Pollutants
Abstract: The aim of this work was to evaluate the oxidative damage to nucleic acids in children (5–11 years) associated with exposure to environmental pollutants and tobacco smoke (ETS). For each subject, urinary sampling was done twice (evening and next morning) to measure by tandem LC–MS–MS such oxidated products of nucleic acids as 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodGuo), 8-oxo-7,8-dihydroguanosine (8-oxoGuo), and 8-oxo-7,8-dihydroguanine (8-oxoGua). Methyl tert- butyl ether (U-MTBE), benzene (U-Benz), and its metabolites ( t,t -muconic and S -phenylmercapturic acids, t,t -MA and S -PMA, respectively) were determined as biomarkers of exposure to air pollution, and cotinine as a biomarker of exposure to ETS. Biomarkers of exposure ( S -PMA and U-MTBE) and of DNA oxidation (8-oxodGuo) were dependent on the urbanization and industrialization levels and increased in the evening sample as compared to next morning ( p <0.05). In both evening and next morning samples, 8-oxodGuo and 8-oxoGuo correlated with each other ( r =0.596 and r =0.537, respectively, p <0.01) and with biomarkers of benzene exposure, particularly S -PMA ( r =0.59 and r =0.45 for 8-oxodGuo and r =0.411 and r =0.383 for 8-oxoGuo, p <0.01). No such correlations were observed for U-MTBE and cotinine. Multiple linear regression analyses showed that 8-oxodGuo was positively associated with S -PMA at both sampling times ( β =0.18 and β =0.14 for evening and next morning sampling, respectively; p <0.02) and weakly with U-MTBE ( β =0.07, p =0.020) only in the evening urines. These results suggest that the selected biomarkers of exposure to benzene, particularly S -PMA, are good tracers of exposure to complex mixtures of oxidative pollutants and that the associated oxidative damage to nucleic acids is detectable even at very low levels of exposure. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Research is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Urinary biomarkers of exposure and of oxidative damage in children exposed to low airborne concentrations of benzene.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Environmental+Research%22&quot;&gt;Environmental Research&lt;/searchLink&gt;. Oct2015, Vol. 142, p264-272. 9p.
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  Data: The aim of this work was to evaluate the oxidative damage to nucleic acids in children (5–11 years) associated with exposure to environmental pollutants and tobacco smoke (ETS). For each subject, urinary sampling was done twice (evening and next morning) to measure by tandem LC–MS–MS such oxidated products of nucleic acids as 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodGuo), 8-oxo-7,8-dihydroguanosine (8-oxoGuo), and 8-oxo-7,8-dihydroguanine (8-oxoGua). Methyl tert- butyl ether (U-MTBE), benzene (U-Benz), and its metabolites ( t,t -muconic and S -phenylmercapturic acids, t,t -MA and S -PMA, respectively) were determined as biomarkers of exposure to air pollution, and cotinine as a biomarker of exposure to ETS. Biomarkers of exposure ( S -PMA and U-MTBE) and of DNA oxidation (8-oxodGuo) were dependent on the urbanization and industrialization levels and increased in the evening sample as compared to next morning ( p &lt;0.05). In both evening and next morning samples, 8-oxodGuo and 8-oxoGuo correlated with each other ( r =0.596 and r =0.537, respectively, p &lt;0.01) and with biomarkers of benzene exposure, particularly S -PMA ( r =0.59 and r =0.45 for 8-oxodGuo and r =0.411 and r =0.383 for 8-oxoGuo, p &lt;0.01). No such correlations were observed for U-MTBE and cotinine. Multiple linear regression analyses showed that 8-oxodGuo was positively associated with S -PMA at both sampling times ( β =0.18 and β =0.14 for evening and next morning sampling, respectively; p &lt;0.02) and weakly with U-MTBE ( β =0.07, p =0.020) only in the evening urines. These results suggest that the selected biomarkers of exposure to benzene, particularly S -PMA, are good tracers of exposure to complex mixtures of oxidative pollutants and that the associated oxidative damage to nucleic acids is detectable even at very low levels of exposure. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Environmental Research is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.envres.2015.07.003
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        Text: English
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        PageCount: 9
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      – SubjectFull: Biomarkers
        Type: general
      – SubjectFull: Urinary organ physiology
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      – SubjectFull: Benzene analysis
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      – SubjectFull: Juvenile diseases
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