A Hand-Held, Intra-Operative Positron Imaging Probe for Surgical Applications.
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| Title: | A Hand-Held, Intra-Operative Positron Imaging Probe for Surgical Applications. |
|---|---|
| Authors: | Sabet, Hamid1, Stack, Brendan C.2, Nagarkar, Vivek V.3 |
| Source: | IEEE Transactions on Nuclear Science. Oct2015 Part 1, Vol. 62 Issue 5a, p1927-1934. 8p. |
| Subjects: | Medical imaging systems, Tumor surgery, Positrons, Photomultipliers, Gamma rays, Silicon oxide, Scintillators, Detectors |
| Abstract: | We have developed a prototype intra-operative \beta^+ imaging probe to help tumor removal and malignant tissue resection. The probe can be used during surgery to provide clear delineation of malignant tissues. Our probe consists of a hybrid scintillator coupled to a silicon photomultiplier (SiPM) array with associated front-end electronics encapsulated in an ergonomic aluminum housing. Pulse shape discrimination electronics has been implemented and integrated into the downstream data acquisition system. The field of view of the probe is 10 \times 10~\mm^2 realized by a 0.4 mm thick CsI:Tl scintillator coupled to a 1 mm thick LYSO. While CsI:Tl layer acts as \beta^+ sensitive detector, LYSO detects gamma radiation where the gamma response can be subtracted from the total signal to improve SNR and contrast. The thickness of the LYSO scintillator is optimized such that it acts as light diffuser to spread the scintillation light generated in CsI:Tl over multiple SiPM pixels for accurate estimation of the \beta^+ interaction location. The probe shows < 1~\mm FWHM spatial resolution in the presence of large background radiation. The probe was used to study rabbits with tongue tumors. The experimental results show that the probe can successfully locate the tongue tumors in its active imaging area. [ABSTRACT FROM AUTHOR] |
| Copyright of IEEE Transactions on Nuclear Science is the property of IEEE and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 110334545 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A Hand-Held, Intra-Operative Positron Imaging Probe for Surgical Applications. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Sabet%2C+Hamid%22">Sabet, Hamid</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Stack%2C+Brendan+C%2E%22">Stack, Brendan C.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Nagarkar%2C+Vivek+V%2E%22">Nagarkar, Vivek V.</searchLink><relatesTo>3</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22IEEE+Transactions+on+Nuclear+Science%22">IEEE Transactions on Nuclear Science</searchLink>. Oct2015 Part 1, Vol. 62 Issue 5a, p1927-1934. 8p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Medical+imaging+systems%22">Medical imaging systems</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+surgery%22">Tumor surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Positrons%22">Positrons</searchLink><br /><searchLink fieldCode="DE" term="%22Photomultipliers%22">Photomultipliers</searchLink><br /><searchLink fieldCode="DE" term="%22Gamma+rays%22">Gamma rays</searchLink><br /><searchLink fieldCode="DE" term="%22Silicon+oxide%22">Silicon oxide</searchLink><br /><searchLink fieldCode="DE" term="%22Scintillators%22">Scintillators</searchLink><br /><searchLink fieldCode="DE" term="%22Detectors%22">Detectors</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: We have developed a prototype intra-operative \beta^+ imaging probe to help tumor removal and malignant tissue resection. The probe can be used during surgery to provide clear delineation of malignant tissues. Our probe consists of a hybrid scintillator coupled to a silicon photomultiplier (SiPM) array with associated front-end electronics encapsulated in an ergonomic aluminum housing. Pulse shape discrimination electronics has been implemented and integrated into the downstream data acquisition system. The field of view of the probe is 10 \times 10~\mm^2 realized by a 0.4 mm thick CsI:Tl scintillator coupled to a 1 mm thick LYSO. While CsI:Tl layer acts as \beta^+ sensitive detector, LYSO detects gamma radiation where the gamma response can be subtracted from the total signal to improve SNR and contrast. The thickness of the LYSO scintillator is optimized such that it acts as light diffuser to spread the scintillation light generated in CsI:Tl over multiple SiPM pixels for accurate estimation of the \beta^+ interaction location. The probe shows < 1~\mm FWHM spatial resolution in the presence of large background radiation. The probe was used to study rabbits with tongue tumors. The experimental results show that the probe can successfully locate the tongue tumors in its active imaging area. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of IEEE Transactions on Nuclear Science is the property of IEEE and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1109/TNS.2015.2446434 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 1927 Subjects: – SubjectFull: Medical imaging systems Type: general – SubjectFull: Tumor surgery Type: general – SubjectFull: Positrons Type: general – SubjectFull: Photomultipliers Type: general – SubjectFull: Gamma rays Type: general – SubjectFull: Silicon oxide Type: general – SubjectFull: Scintillators Type: general – SubjectFull: Detectors Type: general Titles: – TitleFull: A Hand-Held, Intra-Operative Positron Imaging Probe for Surgical Applications. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sabet, Hamid – PersonEntity: Name: NameFull: Stack, Brendan C. – PersonEntity: Name: NameFull: Nagarkar, Vivek V. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2015 Part 1 Type: published Y: 2015 Identifiers: – Type: issn-print Value: 00189499 Numbering: – Type: volume Value: 62 – Type: issue Value: 5a Titles: – TitleFull: IEEE Transactions on Nuclear Science Type: main |
| ResultId | 1 |
