View in EDS

Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii.

Saved in:
Bibliographic Details
Title: Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii.
Authors: Zhao-Rong Lun1,2,3 lsslzr@mail.sysu.edu.cn, De-Hua Lai1, Yan-Zi Wen1, Ling-Ling Zheng1, Ji-Long Shen4, Ting-Bo Yang1, Wen-Liang Zhou1, Liang-Hu Qu1, Hide, Geoff3 g.hide@salford.ac.uk, Ayala, Francisco J.5 fjayala@uci.edu
Source: Proceedings of the National Academy of Sciences of the United States of America. 7/21/2015, Vol. 112 Issue 29, p8835-8842. 8p.
Subjects: Cancer research, Trypanosoma brucei, Toxoplasma gondii, Cancer cells, Vertebrates
Abstract: Cancer is a general name for more than 100 malignant diseases. It is postulated that all cancers start from a single abnormal cell that grows out of control. Untreated cancers can cause serious conse- quences and deaths. Great progress has been made in cancer research that has significantly improved our knowledge and understanding of the nature and mechanisms of the disease, but the origins of cancer are far from being well understood due to the limitations of suitable model systems and to the complexities of the disease. In view of the fact that cancers are found in various species of vertebrates and other metazoa, here, we suggest that cancer also occurs in parasitic protoz- oans such as Trypanosoma brucei, a blood parasite, and Toxoplasma gondii, an obligate intracellular pathogen. Without treatment, these protozoan cancers may cause severe disease and death in mammals, including humans. The simpler genomes of these single-cell organ- isms, in combination with their complex life cycles and fascinating life cycle differentiation processes, may help us to better understand the origins of cancers and, in particular, leukemias. [ABSTRACT FROM AUTHOR]
Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 110349841
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Zhao-Rong+Lun%22">Zhao-Rong Lun</searchLink><relatesTo>1,2,3</relatesTo><i> lsslzr@mail.sysu.edu.cn</i><br /><searchLink fieldCode="AR" term="%22De-Hua+Lai%22">De-Hua Lai</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Yan-Zi+Wen%22">Yan-Zi Wen</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ling-Ling+Zheng%22">Ling-Ling Zheng</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ji-Long+Shen%22">Ji-Long Shen</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Ting-Bo+Yang%22">Ting-Bo Yang</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Wen-Liang+Zhou%22">Wen-Liang Zhou</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Liang-Hu+Qu%22">Liang-Hu Qu</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hide%2C+Geoff%22">Hide, Geoff</searchLink><relatesTo>3</relatesTo><i> g.hide@salford.ac.uk</i><br /><searchLink fieldCode="AR" term="%22Ayala%2C+Francisco+J%2E%22">Ayala, Francisco J.</searchLink><relatesTo>5</relatesTo><i> fjayala@uci.edu</i>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink>. 7/21/2015, Vol. 112 Issue 29, p8835-8842. 8p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Cancer+research%22">Cancer research</searchLink><br /><searchLink fieldCode="DE" term="%22Trypanosoma+brucei%22">Trypanosoma brucei</searchLink><br /><searchLink fieldCode="DE" term="%22Toxoplasma+gondii%22">Toxoplasma gondii</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+cells%22">Cancer cells</searchLink><br /><searchLink fieldCode="DE" term="%22Vertebrates%22">Vertebrates</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Cancer is a general name for more than 100 malignant diseases. It is postulated that all cancers start from a single abnormal cell that grows out of control. Untreated cancers can cause serious conse- quences and deaths. Great progress has been made in cancer research that has significantly improved our knowledge and understanding of the nature and mechanisms of the disease, but the origins of cancer are far from being well understood due to the limitations of suitable model systems and to the complexities of the disease. In view of the fact that cancers are found in various species of vertebrates and other metazoa, here, we suggest that cancer also occurs in parasitic protoz- oans such as Trypanosoma brucei, a blood parasite, and Toxoplasma gondii, an obligate intracellular pathogen. Without treatment, these protozoan cancers may cause severe disease and death in mammals, including humans. The simpler genomes of these single-cell organ- isms, in combination with their complex life cycles and fascinating life cycle differentiation processes, may help us to better understand the origins of cancers and, in particular, leukemias. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=110349841
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1073/pnas.1502599112
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 8835
    Subjects:
      – SubjectFull: Cancer research
        Type: general
      – SubjectFull: Trypanosoma brucei
        Type: general
      – SubjectFull: Toxoplasma gondii
        Type: general
      – SubjectFull: Cancer cells
        Type: general
      – SubjectFull: Vertebrates
        Type: general
    Titles:
      – TitleFull: Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Zhao-Rong Lun
      – PersonEntity:
          Name:
            NameFull: De-Hua Lai
      – PersonEntity:
          Name:
            NameFull: Yan-Zi Wen
      – PersonEntity:
          Name:
            NameFull: Ling-Ling Zheng
      – PersonEntity:
          Name:
            NameFull: Ji-Long Shen
      – PersonEntity:
          Name:
            NameFull: Ting-Bo Yang
      – PersonEntity:
          Name:
            NameFull: Wen-Liang Zhou
      – PersonEntity:
          Name:
            NameFull: Liang-Hu Qu
      – PersonEntity:
          Name:
            NameFull: Hide, Geoff
      – PersonEntity:
          Name:
            NameFull: Ayala, Francisco J.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 21
              M: 07
              Text: 7/21/2015
              Type: published
              Y: 2015
          Identifiers:
            – Type: issn-print
              Value: 00278424
          Numbering:
            – Type: volume
              Value: 112
            – Type: issue
              Value: 29
          Titles:
            – TitleFull: Proceedings of the National Academy of Sciences of the United States of America
              Type: main
ResultId 1