In Vivo Mechanical Characterization of the Distraction Callus During Bone Consolidation.
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| Title: | In Vivo Mechanical Characterization of the Distraction Callus During Bone Consolidation. |
|---|---|
| Authors: | Mora-Macías, J.1 juanmora@us.es, Reina-Romo, E.1 erreina@us.es, López-Pliego, M.2 macarenalopezpliego@gmail.com, Giráldez-Sánchez, M.2 miguelgiraldez@yahoo.com, Domínguez, J.1 jaime@us.es |
| Source: | Annals of Biomedical Engineering. Nov2015, Vol. 43 Issue 11, p2663-2674. 12p. 2 Color Photographs, 1 Illustration, 3 Diagrams, 3 Charts, 1 Graph. |
| Subjects: | Callus, Bone regeneration, Bone fractures, Bone cells, Connective tissues, Skeleton |
| Abstract: | Understanding the evolution of callus mechanical properties over time provides insights in the mechanobiology of fracture healing and tissue differentiation, can be used to validate numerical models, and informs clinical practice. Bone transport experiments were performed in sheep, in which a distractor type Ilizarov was implanted. The forces through the fixator evolution were measured and the callus stiffness was estimated from these forces. Computerized tomography images were taken and bone volume of the callus at different stages was obtained. The results showed that the maximum bone tissue production rate (0.146 cm/day) was achieved 20 days after the end of the distraction phase. 50 days after the end of the distraction phase, the callus was ossified completely and had its maximum volume, 6-10 cm. In addition, 80-90% of the load sustained by the operated limb was recovered and the callus stiffness increased exponentially until 5.4-11.4 kN/mm, still below 10% of the healthy level of callus stiffness. The effects of the bony bridging of the callus and the time of the fixator removal on callus force, stiffness and volume were analyzed. These outcomes allowed relating quantifiable biological aspects (callus volume and tissue production rate) with mechanical parameters (callus force and stiffness) using data from the same experiment. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 110427202 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: In Vivo Mechanical Characterization of the Distraction Callus During Bone Consolidation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Mora-Macías%2C+J%2E%22">Mora-Macías, J.</searchLink><relatesTo>1</relatesTo><i> juanmora@us.es</i><br /><searchLink fieldCode="AR" term="%22Reina-Romo%2C+E%2E%22">Reina-Romo, E.</searchLink><relatesTo>1</relatesTo><i> erreina@us.es</i><br /><searchLink fieldCode="AR" term="%22López-Pliego%2C+M%2E%22">López-Pliego, M.</searchLink><relatesTo>2</relatesTo><i> macarenalopezpliego@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Giráldez-Sánchez%2C+M%2E%22">Giráldez-Sánchez, M.</searchLink><relatesTo>2</relatesTo><i> miguelgiraldez@yahoo.com</i><br /><searchLink fieldCode="AR" term="%22Domínguez%2C+J%2E%22">Domínguez, J.</searchLink><relatesTo>1</relatesTo><i> jaime@us.es</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Biomedical+Engineering%22">Annals of Biomedical Engineering</searchLink>. Nov2015, Vol. 43 Issue 11, p2663-2674. 12p. 2 Color Photographs, 1 Illustration, 3 Diagrams, 3 Charts, 1 Graph. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Callus%22">Callus</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+regeneration%22">Bone regeneration</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+fractures%22">Bone fractures</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+cells%22">Bone cells</searchLink><br /><searchLink fieldCode="DE" term="%22Connective+tissues%22">Connective tissues</searchLink><br /><searchLink fieldCode="DE" term="%22Skeleton%22">Skeleton</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Understanding the evolution of callus mechanical properties over time provides insights in the mechanobiology of fracture healing and tissue differentiation, can be used to validate numerical models, and informs clinical practice. Bone transport experiments were performed in sheep, in which a distractor type Ilizarov was implanted. The forces through the fixator evolution were measured and the callus stiffness was estimated from these forces. Computerized tomography images were taken and bone volume of the callus at different stages was obtained. The results showed that the maximum bone tissue production rate (0.146 cm/day) was achieved 20 days after the end of the distraction phase. 50 days after the end of the distraction phase, the callus was ossified completely and had its maximum volume, 6-10 cm. In addition, 80-90% of the load sustained by the operated limb was recovered and the callus stiffness increased exponentially until 5.4-11.4 kN/mm, still below 10% of the healthy level of callus stiffness. The effects of the bony bridging of the callus and the time of the fixator removal on callus force, stiffness and volume were analyzed. These outcomes allowed relating quantifiable biological aspects (callus volume and tissue production rate) with mechanical parameters (callus force and stiffness) using data from the same experiment. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Biomedical Engineering is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10439-015-1330-7 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 2663 Subjects: – SubjectFull: Callus Type: general – SubjectFull: Bone regeneration Type: general – SubjectFull: Bone fractures Type: general – SubjectFull: Bone cells Type: general – SubjectFull: Connective tissues Type: general – SubjectFull: Skeleton Type: general Titles: – TitleFull: In Vivo Mechanical Characterization of the Distraction Callus During Bone Consolidation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Mora-Macías, J. – PersonEntity: Name: NameFull: Reina-Romo, E. – PersonEntity: Name: NameFull: López-Pliego, M. – PersonEntity: Name: NameFull: Giráldez-Sánchez, M. – PersonEntity: Name: NameFull: Domínguez, J. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2015 Type: published Y: 2015 Identifiers: – Type: issn-print Value: 00906964 Numbering: – Type: volume Value: 43 – Type: issue Value: 11 Titles: – TitleFull: Annals of Biomedical Engineering Type: main |
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