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3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles.

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Title: 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles.
Authors: Khaled, Shaban A.1, Burley, Jonathan C.1, Alexander, Morgan R.1, Yang, Jing2, Roberts, Clive J.1 clive.roberts@nottingham.ac.uk
Source: Journal of Controlled Release. Nov2015, Vol. 217, p308-314. 7p.
Subjects: Solid dosage forms, Combination drug therapy, Drug tablets, X-ray powder diffraction, Hydrochlorothiazide, Three-dimensional printing
Abstract: We have used three dimensional (3D) extrusion printing to manufacture a multi-active solid dosage form or so called polypill. This contains five compartmentalised drugs with two independently controlled and well-defined release profiles. This polypill demonstrates that complex medication regimes can be combined in a single personalised tablet. This could potentially improve adherence for those patients currently taking many separate tablets and also allow ready tailoring of a particular drug combination/drug release for the needs of an individual. The polypill here represents a cardiovascular treatment regime with the incorporation of an immediate release compartment with aspirin and hydrochlorothiazide and three sustained release compartments containing pravastatin, atenolol, and ramipril. X-ray powder diffraction (XRPD) and Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR) were used to assess drug-excipient interaction. The printed polypills were evaluated for drug release using USP dissolution testing. We found that the polypill showed the intended immediate and sustained release profiles based upon the active/excipient ratio used. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 110472807
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles.
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  Data: <searchLink fieldCode="DE" term="%22Solid+dosage+forms%22">Solid dosage forms</searchLink><br /><searchLink fieldCode="DE" term="%22Combination+drug+therapy%22">Combination drug therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+tablets%22">Drug tablets</searchLink><br /><searchLink fieldCode="DE" term="%22X-ray+powder+diffraction%22">X-ray powder diffraction</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrochlorothiazide%22">Hydrochlorothiazide</searchLink><br /><searchLink fieldCode="DE" term="%22Three-dimensional+printing%22">Three-dimensional printing</searchLink>
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  Data: We have used three dimensional (3D) extrusion printing to manufacture a multi-active solid dosage form or so called polypill. This contains five compartmentalised drugs with two independently controlled and well-defined release profiles. This polypill demonstrates that complex medication regimes can be combined in a single personalised tablet. This could potentially improve adherence for those patients currently taking many separate tablets and also allow ready tailoring of a particular drug combination/drug release for the needs of an individual. The polypill here represents a cardiovascular treatment regime with the incorporation of an immediate release compartment with aspirin and hydrochlorothiazide and three sustained release compartments containing pravastatin, atenolol, and ramipril. X-ray powder diffraction (XRPD) and Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR) were used to assess drug-excipient interaction. The printed polypills were evaluated for drug release using USP dissolution testing. We found that the polypill showed the intended immediate and sustained release profiles based upon the active/excipient ratio used. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.jconrel.2015.09.028
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      – Code: eng
        Text: English
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        PageCount: 7
        StartPage: 308
    Subjects:
      – SubjectFull: Solid dosage forms
        Type: general
      – SubjectFull: Combination drug therapy
        Type: general
      – SubjectFull: Drug tablets
        Type: general
      – SubjectFull: X-ray powder diffraction
        Type: general
      – SubjectFull: Hydrochlorothiazide
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      – SubjectFull: Three-dimensional printing
        Type: general
    Titles:
      – TitleFull: 3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles.
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            NameFull: Khaled, Shaban A.
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            NameFull: Burley, Jonathan C.
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            NameFull: Alexander, Morgan R.
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            NameFull: Yang, Jing
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            NameFull: Roberts, Clive J.
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              Text: Nov2015
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              Y: 2015
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              Value: 217
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