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Effect of macroscale formation of intraluminal thrombus on blood flow in abdominal aortic aneurysms.

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Title: Effect of macroscale formation of intraluminal thrombus on blood flow in abdominal aortic aneurysms.
Authors: Raptis, Anastasios1, Xenos, Michalis2, Dimas, Stelios3, Giannoukas, Athanasios4, Labropoulos, Nicos5, Bluestein, Danny6, Matsagkas, Miltiadis I.1
Source: Computer Methods in Biomechanics & Biomedical Engineering. Jan2016, Vol. 19 Issue 1, p84-92. 9p.
Subjects: Blood flow, Abdominal aortic aneurysms, Thrombosis, Porous materials, Porosity, Permeability, Geometric approach, Galerkin methods, Mathematical models
Abstract: A mathematical approach of blood flow within an abdominal aortic aneurysm (AAA) with intraluminal thrombus (ILT) is presented. The macroscale formation of ILT is modeled as a growing porous medium with variable porosity and permeability according to values proposed in the literature. The model outlines the effect of a porous ILT on blood flow in AAAs. The numerical solution is obtained by employing a structured computational mesh of an idealized fusiform AAA geometry and applying the Galerkin weighted residual method in generalized curvilinear coordinates. Results on velocity and pressure fields of independent cases with and without ILT are presented and discussed. The vortices that develop within the aneurysmal cavity are studied and visualized as ILT becomes more condensed. From a mechanistic point of view, the reduction of bulge pressure, as ILT is thickening, supports the observation that ILT could protect the AAA from a possible rupture. The model also predicts a relocation of the maximum pressure region toward the zone proximal to the neck of the aneurysm. However, other mechanisms, such as the gradual wall weakening that usually accompany AAA and ILT formation, which are not included in this study, may offset this effect. [ABSTRACT FROM PUBLISHER]
Copyright of Computer Methods in Biomechanics & Biomedical Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Effect of macroscale formation of intraluminal thrombus on blood flow in abdominal aortic aneurysms.
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  Data: <searchLink fieldCode="JN" term="%22Computer+Methods+in+Biomechanics+%26+Biomedical+Engineering%22">Computer Methods in Biomechanics & Biomedical Engineering</searchLink>. Jan2016, Vol. 19 Issue 1, p84-92. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Blood+flow%22">Blood flow</searchLink><br /><searchLink fieldCode="DE" term="%22Abdominal+aortic+aneurysms%22">Abdominal aortic aneurysms</searchLink><br /><searchLink fieldCode="DE" term="%22Thrombosis%22">Thrombosis</searchLink><br /><searchLink fieldCode="DE" term="%22Porous+materials%22">Porous materials</searchLink><br /><searchLink fieldCode="DE" term="%22Porosity%22">Porosity</searchLink><br /><searchLink fieldCode="DE" term="%22Permeability%22">Permeability</searchLink><br /><searchLink fieldCode="DE" term="%22Geometric+approach%22">Geometric approach</searchLink><br /><searchLink fieldCode="DE" term="%22Galerkin+methods%22">Galerkin methods</searchLink><br /><searchLink fieldCode="DE" term="%22Mathematical+models%22">Mathematical models</searchLink>
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  Data: A mathematical approach of blood flow within an abdominal aortic aneurysm (AAA) with intraluminal thrombus (ILT) is presented. The macroscale formation of ILT is modeled as a growing porous medium with variable porosity and permeability according to values proposed in the literature. The model outlines the effect of a porous ILT on blood flow in AAAs. The numerical solution is obtained by employing a structured computational mesh of an idealized fusiform AAA geometry and applying the Galerkin weighted residual method in generalized curvilinear coordinates. Results on velocity and pressure fields of independent cases with and without ILT are presented and discussed. The vortices that develop within the aneurysmal cavity are studied and visualized as ILT becomes more condensed. From a mechanistic point of view, the reduction of bulge pressure, as ILT is thickening, supports the observation that ILT could protect the AAA from a possible rupture. The model also predicts a relocation of the maximum pressure region toward the zone proximal to the neck of the aneurysm. However, other mechanisms, such as the gradual wall weakening that usually accompany AAA and ILT formation, which are not included in this study, may offset this effect. [ABSTRACT FROM PUBLISHER]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Computer Methods in Biomechanics & Biomedical Engineering is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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        Value: 10.1080/10255842.2014.989389
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      – Code: eng
        Text: English
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        PageCount: 9
        StartPage: 84
    Subjects:
      – SubjectFull: Blood flow
        Type: general
      – SubjectFull: Abdominal aortic aneurysms
        Type: general
      – SubjectFull: Thrombosis
        Type: general
      – SubjectFull: Porous materials
        Type: general
      – SubjectFull: Porosity
        Type: general
      – SubjectFull: Permeability
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      – SubjectFull: Geometric approach
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      – SubjectFull: Galerkin methods
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      – SubjectFull: Mathematical models
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      – TitleFull: Effect of macroscale formation of intraluminal thrombus on blood flow in abdominal aortic aneurysms.
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              Text: Jan2016
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              Y: 2016
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