Bibliographic Details
| Title: |
Evidence for a Functional O-Linked N-Acetylglucosamine (O-GlcNAc) System in the Thermophilic Bacterium Thermobaculum terrenum. |
| Authors: |
Ostrowski, Adam1, Gundogdu, Mehmet1, Ferenbach, Andrew T.2, Lebedev, Andrey A.3, van Aalten, Daan M. F.1,2 vanaalten@dundee.ac.uk |
| Source: |
Journal of Biological Chemistry. 18/12/2015, Vol. 290 Issue 51, p30291-30305. 15p. |
| Subjects: |
Protein analysis, Metazoa, Thermophilic bacteria, Hydrolases, Transferase structure |
| Abstract: |
Background: ProteinO-GlcNAcylation is essential for function and stability of many proteins in metazoa and is essential for development. Results: Thermobaculum terrenum encodes a functional O-GlcNAc hydrolase and a conserved O-GlcNAc-transferase. Conclusion: T. terrenum is the first known bacterium to possess the components for a functional O-GlcNAc system. Significance: T. terrenum could become a reductionist model to study protein O-GlcNAcylation on an organism level. [ABSTRACT FROM AUTHOR] |
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| Database: |
Engineering Source |
