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Three-dimensional fuse deposition modeling of tissue-simulating phantom for biomedical optical imaging.

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Title: Three-dimensional fuse deposition modeling of tissue-simulating phantom for biomedical optical imaging.
Authors: Erbao Dong1, Zuhua Zhao1, Minjie Wang1, Yanjun Xie1, Shidi Li1, Pengfei Shao1, Liuquan Cheng2, Xu, Ronald X.1,3 xu.ronald@hotmail.com
Source: Journal of Biomedical Optics. Dec2015, Vol. 20 Issue 12, p1-10. 10p.
Subjects: Imaging phantoms, Tissues -- Models, Bio-optics, Bioluminescence, Intrinsic optical imaging
Abstract: Biomedical optical devices are widely used for clinical detection of various tissue anomalies. However, optical measurements have limited accuracy and traceability, partially owing to the lack of effective calibration methods that simulate the actual tissue conditions. To facilitate standardized calibration and performance evaluation of medical optical devices, we develop a three-dimensional fuse deposition modeling (FDM) technique for freeform fabrication of tissue-simulating phantoms. The FDM system uses transparent gel wax as the base material, titanium dioxide (TiO2) powder as the scattering ingredient, and graphite powder as the absorption ingredient. The ingredients are preheated, mixed, and deposited at the designated ratios layer-by-layer to simulate tissue structural and optical heterogeneities. By printing the sections of human brain model based on magnetic resonance images, we demonstrate the capability for simulating tissue structural heterogeneities. By measuring optical properties of multilayered phantoms and comparing with numerical simulation, we demonstrate the feasibility for simulating tissue optical properties. By creating a rat head phantom with embedded vasculature, we demonstrate the potential for mimicking physiologic processes of a living system. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Biomedical Optics is the property of SPIE - International Society of Optical Engineering and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 112239509
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Label: Title
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  Data: Three-dimensional fuse deposition modeling of tissue-simulating phantom for biomedical optical imaging.
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  Data: <searchLink fieldCode="AR" term="%22Erbao+Dong%22">Erbao Dong</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Zuhua+Zhao%22">Zuhua Zhao</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Minjie+Wang%22">Minjie Wang</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Yanjun+Xie%22">Yanjun Xie</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Shidi+Li%22">Shidi Li</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Pengfei+Shao%22">Pengfei Shao</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Liuquan+Cheng%22">Liuquan Cheng</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Xu%2C+Ronald+X%2E%22">Xu, Ronald X.</searchLink><relatesTo>1,3</relatesTo><i> xu.ronald@hotmail.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Biomedical+Optics%22">Journal of Biomedical Optics</searchLink>. Dec2015, Vol. 20 Issue 12, p1-10. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Imaging+phantoms%22">Imaging phantoms</searchLink><br /><searchLink fieldCode="DE" term="%22Tissues+--+Models%22">Tissues -- Models</searchLink><br /><searchLink fieldCode="DE" term="%22Bio-optics%22">Bio-optics</searchLink><br /><searchLink fieldCode="DE" term="%22Bioluminescence%22">Bioluminescence</searchLink><br /><searchLink fieldCode="DE" term="%22Intrinsic+optical+imaging%22">Intrinsic optical imaging</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Biomedical optical devices are widely used for clinical detection of various tissue anomalies. However, optical measurements have limited accuracy and traceability, partially owing to the lack of effective calibration methods that simulate the actual tissue conditions. To facilitate standardized calibration and performance evaluation of medical optical devices, we develop a three-dimensional fuse deposition modeling (FDM) technique for freeform fabrication of tissue-simulating phantoms. The FDM system uses transparent gel wax as the base material, titanium dioxide (TiO2) powder as the scattering ingredient, and graphite powder as the absorption ingredient. The ingredients are preheated, mixed, and deposited at the designated ratios layer-by-layer to simulate tissue structural and optical heterogeneities. By printing the sections of human brain model based on magnetic resonance images, we demonstrate the capability for simulating tissue structural heterogeneities. By measuring optical properties of multilayered phantoms and comparing with numerical simulation, we demonstrate the feasibility for simulating tissue optical properties. By creating a rat head phantom with embedded vasculature, we demonstrate the potential for mimicking physiologic processes of a living system. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Biomedical Optics is the property of SPIE - International Society of Optical Engineering and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
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      – Type: doi
        Value: 10.1117/1.JBO.20.12.121311
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      – Code: eng
        Text: English
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        PageCount: 10
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    Subjects:
      – SubjectFull: Imaging phantoms
        Type: general
      – SubjectFull: Tissues -- Models
        Type: general
      – SubjectFull: Bio-optics
        Type: general
      – SubjectFull: Bioluminescence
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      – SubjectFull: Intrinsic optical imaging
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      – TitleFull: Three-dimensional fuse deposition modeling of tissue-simulating phantom for biomedical optical imaging.
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            NameFull: Erbao Dong
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            NameFull: Zuhua Zhao
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            NameFull: Minjie Wang
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            NameFull: Yanjun Xie
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            NameFull: Shidi Li
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            NameFull: Pengfei Shao
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            NameFull: Liuquan Cheng
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              M: 12
              Text: Dec2015
              Type: published
              Y: 2015
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