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Phloroglucinol Reduces Photodamage in Hairless Mice via Matrix Metalloproteinase Activity Through MAPK Pathway.

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Title: Phloroglucinol Reduces Photodamage in Hairless Mice via Matrix Metalloproteinase Activity Through MAPK Pathway.
Authors: Im, A‐Rang1, Nam, Kung‐Woo2, Hyun, Jin Won3, Chae, Sungwook1
Source: Photochemistry & Photobiology. Jan/Feb2016, Vol. 92 Issue 1, p173-179. 7p.
Subjects: Phloroglucinol, Matrix metalloproteinases, Mitogen-activated protein kinases, Ultraviolet radiation, Histology, Collagen, Laboratory mice
Abstract: We investigated the photoprotective activity of phloroglucinol on ultraviolet B ( UVB)-induced deleterious effects in hairless mice in vivo. To assess the photoprotective effect of phloroglucinol, phloroglucinol-treated HR-1 hairless male mice were exposed to UVB irradiation. The inhibitory activity of phloroglucinol on wrinkle formation was determined by analysis of skin replicas, epidermal thickness based on histological examination and collagen damage. Matrix metalloproteinase-1 ( MMP-1), matrix metalloproteinase-9 ( MMP-9) and tissue inhibitor of metalloproteinase ( TIMP) mRNA levels were measured by real-time PCR. UVB induced transcription of proinflammatory cytokines, including interleukin-1 beta ( IL-1 β, IL-6) and IL-8 ( IL-8). The protective effects of phloroglucinol on UVB-induced skin photoaging were examined by measuring protein levels of MMPs and mitogen-activated protein ( MAP) kinases. The results of these experiments suggest that phloroglucinol has a significant beneficial effect on the barrier function of the skin. In hairless mice, signs of photoaging and photodamage, including coarse wrinkle formation, epidermal thickness and elastic fiber degeneration, were reduced in severity by phloroglucinol application. The phloroglucinol-treated group showed remarkably decreased mRNA levels of MMP-1, MMP-9 and inflammatory cytokines in comparison with those of the UVB-induced group. Oral administration of phloroglucinol attenuated phosphorylation of MAP kinases, including extracellular signal-regulated kinase, c-Jun N-terminal kinase and p38. [ABSTRACT FROM AUTHOR]
Copyright of Photochemistry & Photobiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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PubType: Academic Journal
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  Data: Phloroglucinol Reduces Photodamage in Hairless Mice via Matrix Metalloproteinase Activity Through MAPK Pathway.
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  Data: <searchLink fieldCode="AR" term="%22Im%2C+A‐Rang%22">Im, A‐Rang</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Nam%2C+Kung‐Woo%22">Nam, Kung‐Woo</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Hyun%2C+Jin+Won%22">Hyun, Jin Won</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Chae%2C+Sungwook%22">Chae, Sungwook</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Photochemistry+%26+Photobiology%22">Photochemistry & Photobiology</searchLink>. Jan/Feb2016, Vol. 92 Issue 1, p173-179. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Phloroglucinol%22">Phloroglucinol</searchLink><br /><searchLink fieldCode="DE" term="%22Matrix+metalloproteinases%22">Matrix metalloproteinases</searchLink><br /><searchLink fieldCode="DE" term="%22Mitogen-activated+protein+kinases%22">Mitogen-activated protein kinases</searchLink><br /><searchLink fieldCode="DE" term="%22Ultraviolet+radiation%22">Ultraviolet radiation</searchLink><br /><searchLink fieldCode="DE" term="%22Histology%22">Histology</searchLink><br /><searchLink fieldCode="DE" term="%22Collagen%22">Collagen</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+mice%22">Laboratory mice</searchLink>
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  Data: We investigated the photoprotective activity of phloroglucinol on ultraviolet B ( UVB)-induced deleterious effects in hairless mice in vivo. To assess the photoprotective effect of phloroglucinol, phloroglucinol-treated HR-1 hairless male mice were exposed to UVB irradiation. The inhibitory activity of phloroglucinol on wrinkle formation was determined by analysis of skin replicas, epidermal thickness based on histological examination and collagen damage. Matrix metalloproteinase-1 ( MMP-1), matrix metalloproteinase-9 ( MMP-9) and tissue inhibitor of metalloproteinase ( TIMP) mRNA levels were measured by real-time PCR. UVB induced transcription of proinflammatory cytokines, including interleukin-1 beta ( IL-1 β, IL-6) and IL-8 ( IL-8). The protective effects of phloroglucinol on UVB-induced skin photoaging were examined by measuring protein levels of MMPs and mitogen-activated protein ( MAP) kinases. The results of these experiments suggest that phloroglucinol has a significant beneficial effect on the barrier function of the skin. In hairless mice, signs of photoaging and photodamage, including coarse wrinkle formation, epidermal thickness and elastic fiber degeneration, were reduced in severity by phloroglucinol application. The phloroglucinol-treated group showed remarkably decreased mRNA levels of MMP-1, MMP-9 and inflammatory cytokines in comparison with those of the UVB-induced group. Oral administration of phloroglucinol attenuated phosphorylation of MAP kinases, including extracellular signal-regulated kinase, c-Jun N-terminal kinase and p38. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Photochemistry & Photobiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/php.12549
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        Text: English
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        PageCount: 7
        StartPage: 173
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      – SubjectFull: Phloroglucinol
        Type: general
      – SubjectFull: Matrix metalloproteinases
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      – SubjectFull: Mitogen-activated protein kinases
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      – SubjectFull: Ultraviolet radiation
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      – SubjectFull: Histology
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      – SubjectFull: Collagen
        Type: general
      – SubjectFull: Laboratory mice
        Type: general
    Titles:
      – TitleFull: Phloroglucinol Reduces Photodamage in Hairless Mice via Matrix Metalloproteinase Activity Through MAPK Pathway.
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            NameFull: Im, A‐Rang
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            NameFull: Nam, Kung‐Woo
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            NameFull: Hyun, Jin Won
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            NameFull: Chae, Sungwook
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              M: 01
              Text: Jan/Feb2016
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              Y: 2016
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