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Artificial oil body as a potential oral administration system in zebrafish.

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Title: Artificial oil body as a potential oral administration system in zebrafish.
Authors: Chiang, Chung-Jen1 cjchiang@mail.cmu.edu.tw, Lin, Li-Jen2, Yang, Tsung Ying1, Chao, Yun-Peng3,4,5 ypchao@fcu.edu.tw
Source: Journal of the Taiwan Institute of Chemical Engineers. Apr2016, Vol. 61, p46-53. 8p.
Subjects: Pharmacodynamics, Oral medication, Cancer treatment, Antineoplastic agents, Laboratory zebrafish, Olive oil
Abstract: Zebrafish are well recognized as an excellent vertebrate model which, in particular, facilitates the rapid investigation of drug effects on cancers. A prerequisite for this anti-cancer study appears to have a non-invasive and effecicve method for admininstration of drugs. In this study, we explored the potential of artificial oil bodies (AOBs) for the oral administration of a hydrophobic agent in adult zebrafish. A hydrophobic dye was employed for illustration, and AOBs were assembled with phospholipids, a storage protein, and an equal volume of olive oil and brine shrimp oil. Consequently, more than 90% of the dye was encapsulated in AOBs which exhibited a prolonged release profile for the dye cargo. The dye-loaded AOBs collected as an oil cake remained integral within 30 min in the aquatic solution while it was completely consumed by one zebrafish in a few seconds. As revealed by the fluorescence microscopy and frozen section, the fluorescence signal was detected in the zebrafish intestinal tract 2 h after the oral administration. The dye cargo was completely absorbed in 12 h and almost no trace was left in zebrafish feces. Overall, the AOBs system is biocompatible and shows promise in the oral administration of chemical entities for zebrafish. [ABSTRACT FROM AUTHOR]
Copyright of Journal of the Taiwan Institute of Chemical Engineers is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
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PubType: Academic Journal
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  Data: Artificial oil body as a potential oral administration system in zebrafish.
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  Data: <searchLink fieldCode="AR" term="%22Chiang%2C+Chung-Jen%22">Chiang, Chung-Jen</searchLink><relatesTo>1</relatesTo><i> cjchiang@mail.cmu.edu.tw</i><br /><searchLink fieldCode="AR" term="%22Lin%2C+Li-Jen%22">Lin, Li-Jen</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Yang%2C+Tsung+Ying%22">Yang, Tsung Ying</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Chao%2C+Yun-Peng%22">Chao, Yun-Peng</searchLink><relatesTo>3,4,5</relatesTo><i> ypchao@fcu.edu.tw</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+the+Taiwan+Institute+of+Chemical+Engineers%22">Journal of the Taiwan Institute of Chemical Engineers</searchLink>. Apr2016, Vol. 61, p46-53. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Pharmacodynamics%22">Pharmacodynamics</searchLink><br /><searchLink fieldCode="DE" term="%22Oral+medication%22">Oral medication</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+treatment%22">Cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Antineoplastic+agents%22">Antineoplastic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+zebrafish%22">Laboratory zebrafish</searchLink><br /><searchLink fieldCode="DE" term="%22Olive+oil%22">Olive oil</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Zebrafish are well recognized as an excellent vertebrate model which, in particular, facilitates the rapid investigation of drug effects on cancers. A prerequisite for this anti-cancer study appears to have a non-invasive and effecicve method for admininstration of drugs. In this study, we explored the potential of artificial oil bodies (AOBs) for the oral administration of a hydrophobic agent in adult zebrafish. A hydrophobic dye was employed for illustration, and AOBs were assembled with phospholipids, a storage protein, and an equal volume of olive oil and brine shrimp oil. Consequently, more than 90% of the dye was encapsulated in AOBs which exhibited a prolonged release profile for the dye cargo. The dye-loaded AOBs collected as an oil cake remained integral within 30 min in the aquatic solution while it was completely consumed by one zebrafish in a few seconds. As revealed by the fluorescence microscopy and frozen section, the fluorescence signal was detected in the zebrafish intestinal tract 2 h after the oral administration. The dye cargo was completely absorbed in 12 h and almost no trace was left in zebrafish feces. Overall, the AOBs system is biocompatible and shows promise in the oral administration of chemical entities for zebrafish. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Journal of the Taiwan Institute of Chemical Engineers is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=113592205
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      – Type: doi
        Value: 10.1016/j.jtice.2015.12.013
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      – Code: eng
        Text: English
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      – SubjectFull: Pharmacodynamics
        Type: general
      – SubjectFull: Oral medication
        Type: general
      – SubjectFull: Cancer treatment
        Type: general
      – SubjectFull: Antineoplastic agents
        Type: general
      – SubjectFull: Laboratory zebrafish
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      – SubjectFull: Olive oil
        Type: general
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      – TitleFull: Artificial oil body as a potential oral administration system in zebrafish.
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            NameFull: Lin, Li-Jen
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            NameFull: Yang, Tsung Ying
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            NameFull: Chao, Yun-Peng
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              Text: Apr2016
              Type: published
              Y: 2016
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              Value: 61
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