Modification of the association of bisphenol A with abnormal liver function by polymorphisms of oxidative stress-related genes.
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| Title: | Modification of the association of bisphenol A with abnormal liver function by polymorphisms of oxidative stress-related genes. |
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| Authors: | Kim, Jin Hee1,2, Lee, Mee-Ri3, Hong, Yun-Chul3,4 ychong1@snu.ac.kr |
| Source: | Environmental Research. May2016, Vol. 147, p324-330. 7p. |
| Subjects: | Bisphenol A, Liver function tests, Genetic polymorphisms, Liver abnormalities, Oxidative stress |
| Abstract: | Some studies suggested oxidative stress as a possible mechanism for the relation between exposure to bisphenol A (BPA) and liver damage. Therefore, we evaluated modification of genetic polymorphisms of cyclooxygenase 2 ( COX2 or PTGS2 ), epoxide hydrolase 1 ( EPHX1 ), catalase ( CAT ), and superoxide dismutase 2 ( SOD2 or MnSOD ), which are oxidative stress-related genes, on the relation between exposure to BPA and liver function in the elderly. We assessed the association of visit-to-visit variations in BPA exposure with abnormal liver function by each genotype or haplotype after controlling for age, sex, BMI, alcohol consumption, exercise, urinary cotinine levels, and low density lipoprotein cholesterol using a GLIMMIX model. A significant association of BPA with abnormal liver function was observed only in participants with COX2 GG genotype at rs5277 (odds ratio (OR)=3.04 and p =0.0231), CAT genotype at rs769218 (OR=4.16 and p =0.0356), CAT CT genotype at rs769217 (OR=4.19 and p =0.0348), SOD2 TT genotype at rs4880 (OR=2.59 and p =0.0438), or SOD2 GG genotype at rs2758331 (OR=2.57 and p =0.0457). Moreover, we also found higher OR values in participants with a pair of G-G haplotypes for COX2 (OR=2.81 and p =0.0384), G-C-A haplotype for EPHX1 (OR=4.63 and p =0.0654), A-T haplotype for CAT (OR=4.48 and p =0.0245), or T-G-A haplotype for SOD2 (OR=2.91 and p =0.0491) compared with those with the other pair of haplotypes for each gene. Furthermore, the risk score composed of 4 risky pair of haplotypes showed interactive effect with BPA on abnormal liver function ( p =0.0057). Our study results suggest that genetic polymorphisms of COX2 , EPHX1 , CAT , and SOD2 modify the association of BPA with liver function. [ABSTRACT FROM AUTHOR] |
| Copyright of Environmental Research is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 114176870 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Modification of the association of bisphenol A with abnormal liver function by polymorphisms of oxidative stress-related genes. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kim%2C+Jin+Hee%22">Kim, Jin Hee</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Lee%2C+Mee-Ri%22">Lee, Mee-Ri</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Hong%2C+Yun-Chul%22">Hong, Yun-Chul</searchLink><relatesTo>3,4</relatesTo><i> ychong1@snu.ac.kr</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Environmental+Research%22">Environmental Research</searchLink>. May2016, Vol. 147, p324-330. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Bisphenol+A%22">Bisphenol A</searchLink><br /><searchLink fieldCode="DE" term="%22Liver+function+tests%22">Liver function tests</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Liver+abnormalities%22">Liver abnormalities</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidative+stress%22">Oxidative stress</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Some studies suggested oxidative stress as a possible mechanism for the relation between exposure to bisphenol A (BPA) and liver damage. Therefore, we evaluated modification of genetic polymorphisms of cyclooxygenase 2 ( COX2 or PTGS2 ), epoxide hydrolase 1 ( EPHX1 ), catalase ( CAT ), and superoxide dismutase 2 ( SOD2 or MnSOD ), which are oxidative stress-related genes, on the relation between exposure to BPA and liver function in the elderly. We assessed the association of visit-to-visit variations in BPA exposure with abnormal liver function by each genotype or haplotype after controlling for age, sex, BMI, alcohol consumption, exercise, urinary cotinine levels, and low density lipoprotein cholesterol using a GLIMMIX model. A significant association of BPA with abnormal liver function was observed only in participants with COX2 GG genotype at rs5277 (odds ratio (OR)=3.04 and p =0.0231), CAT genotype at rs769218 (OR=4.16 and p =0.0356), CAT CT genotype at rs769217 (OR=4.19 and p =0.0348), SOD2 TT genotype at rs4880 (OR=2.59 and p =0.0438), or SOD2 GG genotype at rs2758331 (OR=2.57 and p =0.0457). Moreover, we also found higher OR values in participants with a pair of G-G haplotypes for COX2 (OR=2.81 and p =0.0384), G-C-A haplotype for EPHX1 (OR=4.63 and p =0.0654), A-T haplotype for CAT (OR=4.48 and p =0.0245), or T-G-A haplotype for SOD2 (OR=2.91 and p =0.0491) compared with those with the other pair of haplotypes for each gene. Furthermore, the risk score composed of 4 risky pair of haplotypes showed interactive effect with BPA on abnormal liver function ( p =0.0057). Our study results suggest that genetic polymorphisms of COX2 , EPHX1 , CAT , and SOD2 modify the association of BPA with liver function. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Environmental Research is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.envres.2016.02.026 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 324 Subjects: – SubjectFull: Bisphenol A Type: general – SubjectFull: Liver function tests Type: general – SubjectFull: Genetic polymorphisms Type: general – SubjectFull: Liver abnormalities Type: general – SubjectFull: Oxidative stress Type: general Titles: – TitleFull: Modification of the association of bisphenol A with abnormal liver function by polymorphisms of oxidative stress-related genes. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kim, Jin Hee – PersonEntity: Name: NameFull: Lee, Mee-Ri – PersonEntity: Name: NameFull: Hong, Yun-Chul IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2016 Type: published Y: 2016 Identifiers: – Type: issn-print Value: 00139351 Numbering: – Type: volume Value: 147 Titles: – TitleFull: Environmental Research Type: main |
| ResultId | 1 |
