Spectrophotometric Method for the Determination of Two Coformulated Drugs with Highly Different Concentrations. Application on Vildagliptin and Metformin Hydrochloride.
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| Title: | Spectrophotometric Method for the Determination of Two Coformulated Drugs with Highly Different Concentrations. Application on Vildagliptin and Metformin Hydrochloride. |
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| Authors: | Zaazaa, H.1, Elzanfaly, E.1, Soudi, A.1 aya.soudi@pharma.cu.edu.eg, Salem, M.1 |
| Source: | Journal of Applied Spectroscopy. Mar2016, Vol. 83 Issue 1, p137-140. 4p. |
| Subjects: | Absorbance scale (Spectroscopy), Light absorbance, Absorption spectra, Metformin, Quality control standards |
| Abstract: | A new smart simple validated spectrophotometric method was developed for the determination of two drugs one of which is in a very low concentration compared to the other. The method is based on spiking and dilution then simple mathematical manipulation of the absorbance spectra. This method was applied for the determination of a binary mixture of vildagliptin and metformin hydrochloride in the ratio 50:850 in laboratory prepared mixtures containing both drugs in this ratio and in pharmaceutical dosage form with good recoveries. The developed method was validated according to ICH guidelines and can be used for routine quality control testing. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Applied Spectroscopy is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 114245815 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Spectrophotometric Method for the Determination of Two Coformulated Drugs with Highly Different Concentrations. Application on Vildagliptin and Metformin Hydrochloride. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Zaazaa%2C+H%2E%22">Zaazaa, H.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Elzanfaly%2C+E%2E%22">Elzanfaly, E.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Soudi%2C+A%2E%22">Soudi, A.</searchLink><relatesTo>1</relatesTo><i> aya.soudi@pharma.cu.edu.eg</i><br /><searchLink fieldCode="AR" term="%22Salem%2C+M%2E%22">Salem, M.</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Applied+Spectroscopy%22">Journal of Applied Spectroscopy</searchLink>. Mar2016, Vol. 83 Issue 1, p137-140. 4p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Absorbance+scale+%28Spectroscopy%29%22">Absorbance scale (Spectroscopy)</searchLink><br /><searchLink fieldCode="DE" term="%22Light+absorbance%22">Light absorbance</searchLink><br /><searchLink fieldCode="DE" term="%22Absorption+spectra%22">Absorption spectra</searchLink><br /><searchLink fieldCode="DE" term="%22Metformin%22">Metformin</searchLink><br /><searchLink fieldCode="DE" term="%22Quality+control+standards%22">Quality control standards</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: A new smart simple validated spectrophotometric method was developed for the determination of two drugs one of which is in a very low concentration compared to the other. The method is based on spiking and dilution then simple mathematical manipulation of the absorbance spectra. This method was applied for the determination of a binary mixture of vildagliptin and metformin hydrochloride in the ratio 50:850 in laboratory prepared mixtures containing both drugs in this ratio and in pharmaceutical dosage form with good recoveries. The developed method was validated according to ICH guidelines and can be used for routine quality control testing. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Applied Spectroscopy is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10812-016-0256-7 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 4 StartPage: 137 Subjects: – SubjectFull: Absorbance scale (Spectroscopy) Type: general – SubjectFull: Light absorbance Type: general – SubjectFull: Absorption spectra Type: general – SubjectFull: Metformin Type: general – SubjectFull: Quality control standards Type: general Titles: – TitleFull: Spectrophotometric Method for the Determination of Two Coformulated Drugs with Highly Different Concentrations. Application on Vildagliptin and Metformin Hydrochloride. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Zaazaa, H. – PersonEntity: Name: NameFull: Elzanfaly, E. – PersonEntity: Name: NameFull: Soudi, A. – PersonEntity: Name: NameFull: Salem, M. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2016 Type: published Y: 2016 Identifiers: – Type: issn-print Value: 00219037 Numbering: – Type: volume Value: 83 – Type: issue Value: 1 Titles: – TitleFull: Journal of Applied Spectroscopy Type: main |
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