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Harnessing the bone-seeking ability of Ca(ii)-like metal ions in the treatment of metastatic cancer and resorption disorders.

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Title: Harnessing the bone-seeking ability of Ca(ii)-like metal ions in the treatment of metastatic cancer and resorption disorders.
Authors: Weekes, D. M.1, Orvig, C.1
Source: Chemical Society Reviews. 4/21/2016, Vol. 45 Issue 8, p2024-2031. 8p.
Subjects: Calcium ions, Bone metastasis, Metal ions, Hydroxyapatite, Drug design, Diagnosis, Therapeutics
Abstract: Metal ions are naturally retained by skeletal tissues in living systems because of their high affinity for the hydroxyapatite-like mineral matrix that makes up cortical bone. This is particularly true for metal ions that bear a close resemblance to calcium(ii) (such as the lanthanides or alkaline earth metals), and in a few key cases this targeting ability has been exploited in order to develop medicinal agents that are intended to treat bones which have become diseased. In this review, we focus on two areas where this has been particularly effective: first is in the diagnosis and therapy of metastatic bone cancer, in which radioactive metal ions including 99mTc, 153Sm, and 223Ra are used to image, alleviate, and ablate harmful cancerous legions with good specificity versus healthy tissues; second is the use of trivalent lanthanides to treat osteoporosis, an emerging concept which has gathered significance over the last 15 years, and is now entering preclinical trials with carefully designed systems. [ABSTRACT FROM AUTHOR]
Copyright of Chemical Society Reviews is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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  Data: <searchLink fieldCode="JN" term="%22Chemical+Society+Reviews%22">Chemical Society Reviews</searchLink>. 4/21/2016, Vol. 45 Issue 8, p2024-2031. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Calcium+ions%22">Calcium ions</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+metastasis%22">Bone metastasis</searchLink><br /><searchLink fieldCode="DE" term="%22Metal+ions%22">Metal ions</searchLink><br /><searchLink fieldCode="DE" term="%22Hydroxyapatite%22">Hydroxyapatite</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+design%22">Drug design</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis%22">Diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink>
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  Data: Metal ions are naturally retained by skeletal tissues in living systems because of their high affinity for the hydroxyapatite-like mineral matrix that makes up cortical bone. This is particularly true for metal ions that bear a close resemblance to calcium(ii) (such as the lanthanides or alkaline earth metals), and in a few key cases this targeting ability has been exploited in order to develop medicinal agents that are intended to treat bones which have become diseased. In this review, we focus on two areas where this has been particularly effective: first is in the diagnosis and therapy of metastatic bone cancer, in which radioactive metal ions including 99mTc, 153Sm, and 223Ra are used to image, alleviate, and ablate harmful cancerous legions with good specificity versus healthy tissues; second is the use of trivalent lanthanides to treat osteoporosis, an emerging concept which has gathered significance over the last 15 years, and is now entering preclinical trials with carefully designed systems. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Chemical Society Reviews is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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        Value: 10.1039/c5cs00712g
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      – Code: eng
        Text: English
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        PageCount: 8
        StartPage: 2024
    Subjects:
      – SubjectFull: Calcium ions
        Type: general
      – SubjectFull: Bone metastasis
        Type: general
      – SubjectFull: Metal ions
        Type: general
      – SubjectFull: Hydroxyapatite
        Type: general
      – SubjectFull: Drug design
        Type: general
      – SubjectFull: Diagnosis
        Type: general
      – SubjectFull: Therapeutics
        Type: general
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      – TitleFull: Harnessing the bone-seeking ability of Ca(ii)-like metal ions in the treatment of metastatic cancer and resorption disorders.
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              Text: 4/21/2016
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              Y: 2016
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