Interindividual registration and dose mapping for voxelwise population analysis of rectal toxicity in prostate cancer radiotherapy.
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| Title: | Interindividual registration and dose mapping for voxelwise population analysis of rectal toxicity in prostate cancer radiotherapy. |
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| Authors: | Dréan, Gaël1, Acosta, Oscar1, Lafond, Caroline2, Simon, Antoine1, de Crevoisier, Renaud2, Haigron, Pascal1 |
| Source: | Medical Physics. Jun2016, Vol. 43 Issue 6, p2721-2730. 10p. |
| Subjects: | Prostate cancer treatment, Cancer radiotherapy, Rectal diseases, Statistics, Medical dosimetry |
| Abstract: | Purpose: Recent studies revealed a trend toward voxelwise population analysis in order to understand the local dose/toxicity relationships in prostate cancer radiotherapy. Such approaches require, however, an accurate interindividual mapping of the anatomies and 3D dose distributions toward a common coordinate system. This step is challenging due to the high interindividual variability. In this paper, the authors propose a method designed for interindividual nonrigid registration of the rectum and dose mapping for population analysis. Methods: The method is based on the computation of a normalized structural description of the rectum using a Laplacian-based model. This description takes advantage of the tubular structure of the rectum and its centerline to be embedded in a nonrigid registration-based scheme. The performances of the method were evaluated on 30 individuals treated for prostate cancer in a leave-one-out cross validation. Results: Performance was measured using classical metrics (Dice score and Hausdorff distance), along with new metrics devised to better assess dose mapping in relation with structural deformation (dose-organ overlap). Considering these scores, the proposed method outperforms intensity-based and distance maps-based registration methods. Conclusions: The proposed method allows for accurately mapping interindividual 3D dose distributions toward a single anatomical template, opening the way for further voxelwise statistical analysis. [ABSTRACT FROM AUTHOR] |
| Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 116000062 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Interindividual registration and dose mapping for voxelwise population analysis of rectal toxicity in prostate cancer radiotherapy. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Dréan%2C+Gaël%22">Dréan, Gaël</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Acosta%2C+Oscar%22">Acosta, Oscar</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lafond%2C+Caroline%22">Lafond, Caroline</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Simon%2C+Antoine%22">Simon, Antoine</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22de+Crevoisier%2C+Renaud%22">de Crevoisier, Renaud</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Haigron%2C+Pascal%22">Haigron, Pascal</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Medical+Physics%22">Medical Physics</searchLink>. Jun2016, Vol. 43 Issue 6, p2721-2730. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Prostate+cancer+treatment%22">Prostate cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+radiotherapy%22">Cancer radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Rectal+diseases%22">Rectal diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+dosimetry%22">Medical dosimetry</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: Recent studies revealed a trend toward voxelwise population analysis in order to understand the local dose/toxicity relationships in prostate cancer radiotherapy. Such approaches require, however, an accurate interindividual mapping of the anatomies and 3D dose distributions toward a common coordinate system. This step is challenging due to the high interindividual variability. In this paper, the authors propose a method designed for interindividual nonrigid registration of the rectum and dose mapping for population analysis. Methods: The method is based on the computation of a normalized structural description of the rectum using a Laplacian-based model. This description takes advantage of the tubular structure of the rectum and its centerline to be embedded in a nonrigid registration-based scheme. The performances of the method were evaluated on 30 individuals treated for prostate cancer in a leave-one-out cross validation. Results: Performance was measured using classical metrics (Dice score and Hausdorff distance), along with new metrics devised to better assess dose mapping in relation with structural deformation (dose-organ overlap). Considering these scores, the proposed method outperforms intensity-based and distance maps-based registration methods. Conclusions: The proposed method allows for accurately mapping interindividual 3D dose distributions toward a single anatomical template, opening the way for further voxelwise statistical analysis. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=116000062 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1118/1.4948501 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 2721 Subjects: – SubjectFull: Prostate cancer treatment Type: general – SubjectFull: Cancer radiotherapy Type: general – SubjectFull: Rectal diseases Type: general – SubjectFull: Statistics Type: general – SubjectFull: Medical dosimetry Type: general Titles: – TitleFull: Interindividual registration and dose mapping for voxelwise population analysis of rectal toxicity in prostate cancer radiotherapy. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Dréan, Gaël – PersonEntity: Name: NameFull: Acosta, Oscar – PersonEntity: Name: NameFull: Lafond, Caroline – PersonEntity: Name: NameFull: Simon, Antoine – PersonEntity: Name: NameFull: de Crevoisier, Renaud – PersonEntity: Name: NameFull: Haigron, Pascal IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2016 Type: published Y: 2016 Identifiers: – Type: issn-print Value: 00942405 Numbering: – Type: volume Value: 43 – Type: issue Value: 6 Titles: – TitleFull: Medical Physics Type: main |
| ResultId | 1 |
