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Aberrant supracallosal longitudinal bundle: MR features, pathogenesis and associated clinical phenotype.

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Title: Aberrant supracallosal longitudinal bundle: MR features, pathogenesis and associated clinical phenotype.
Authors: Arrigoni, Filippo1 filippo.arrigoni@bp.lnf.it, Romaniello, Romina2, Peruzzo, Denis1, Righini, Andrea3, Parazzini, Cecilia3, Colombo, Paola4, Bassi, Maria5, Triulzi, Fabio6, Borgatti, Renato2, Bassi, Maria Teresa7 (AUTHOR)
Source: European Radiology. Aug2016, Vol. 26 Issue 8, p2587-2596. 10p.
Subjects: Corpus callosum, Magnetic resonance imaging of the brain, Phenotypes, Diffusion tensor imaging, Hippocampus (Brain), Diseases
Abstract: Objective: To describe the MRI and structural features of a peculiar malformation of the corpus callosum (CC) in a group of young patients with intellectual disability.Methods: We studied with conventional MRI and DTI a group of subjects showing an aberrant supracallosal bundle, characterized by the presence of a triangle-shaped bulging above the dorsal surface of CC on the midline. Clinical evaluations, CGH-array and instrumental analysis were also collected.Results: Among 85 patients with malformed CC, we identified 15 subjects that showed the supracallosal bundle. The CC was thickened in five cases, long and thinned in three cases, short and thinned in three cases and it had a "ribbon-like" appearance in four subjects. Additional brain anomalies were present in eight cases. DTI colour maps and tractography showed that the bundle had an antero-posterior longitudinal orientation and that the tract bifurcated posteriorly, ending in the posterior hippocampi. Patients had different combinations of neurological symptoms, but all showed mild or severe intellectual disability.Conclusions: Combining radiological and genetic data with embryological knowledge of the development of cerebral commissures, we hypothesize that the supracallosal bundle represents a vestigial structure, the dorsal fornix, present during fetal life. Its persistence is associated with intellectual disability.Key Points: • An aberrant longitudinal bundle can be detected above corpus callosum. • The presence of the supracallosal bundle is associated with intellectual disability. • The supracallosal bundle may represent a persistent dorsal fornix. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Aberrant supracallosal longitudinal bundle: MR features, pathogenesis and associated clinical phenotype.
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  Data: <searchLink fieldCode="AR" term="%22Arrigoni%2C+Filippo%22">Arrigoni, Filippo</searchLink><relatesTo>1</relatesTo><i> filippo.arrigoni@bp.lnf.it</i><br /><searchLink fieldCode="AR" term="%22Romaniello%2C+Romina%22">Romaniello, Romina</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Peruzzo%2C+Denis%22">Peruzzo, Denis</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Righini%2C+Andrea%22">Righini, Andrea</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Parazzini%2C+Cecilia%22">Parazzini, Cecilia</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Colombo%2C+Paola%22">Colombo, Paola</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Bassi%2C+Maria%22">Bassi, Maria</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Triulzi%2C+Fabio%22">Triulzi, Fabio</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Borgatti%2C+Renato%22">Borgatti, Renato</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Bassi%2C+Maria+Teresa%22">Bassi, Maria Teresa</searchLink><relatesTo>7</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Aug2016, Vol. 26 Issue 8, p2587-2596. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Corpus+callosum%22">Corpus callosum</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging+of+the+brain%22">Magnetic resonance imaging of the brain</searchLink><br /><searchLink fieldCode="DE" term="%22Phenotypes%22">Phenotypes</searchLink><br /><searchLink fieldCode="DE" term="%22Diffusion+tensor+imaging%22">Diffusion tensor imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Hippocampus+%28Brain%29%22">Hippocampus (Brain)</searchLink><br /><searchLink fieldCode="DE" term="%22Diseases%22">Diseases</searchLink>
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  Data: <bold>Objective: </bold>To describe the MRI and structural features of a peculiar malformation of the corpus callosum (CC) in a group of young patients with intellectual disability.<bold>Methods: </bold>We studied with conventional MRI and DTI a group of subjects showing an aberrant supracallosal bundle, characterized by the presence of a triangle-shaped bulging above the dorsal surface of CC on the midline. Clinical evaluations, CGH-array and instrumental analysis were also collected.<bold>Results: </bold>Among 85 patients with malformed CC, we identified 15 subjects that showed the supracallosal bundle. The CC was thickened in five cases, long and thinned in three cases, short and thinned in three cases and it had a "ribbon-like" appearance in four subjects. Additional brain anomalies were present in eight cases. DTI colour maps and tractography showed that the bundle had an antero-posterior longitudinal orientation and that the tract bifurcated posteriorly, ending in the posterior hippocampi. Patients had different combinations of neurological symptoms, but all showed mild or severe intellectual disability.<bold>Conclusions: </bold>Combining radiological and genetic data with embryological knowledge of the development of cerebral commissures, we hypothesize that the supracallosal bundle represents a vestigial structure, the dorsal fornix, present during fetal life. Its persistence is associated with intellectual disability.<bold>Key Points: </bold>• An aberrant longitudinal bundle can be detected above corpus callosum. • The presence of the supracallosal bundle is associated with intellectual disability. • The supracallosal bundle may represent a persistent dorsal fornix. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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