Characterization of a synthetic single crystal diamond detector for dosimetry in spatially fractionated synchrotron x-ray fields.
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| Title: | Characterization of a synthetic single crystal diamond detector for dosimetry in spatially fractionated synchrotron x-ray fields. |
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| Authors: | Livingstone, Jayde1, Stevenson, Andrew W.2, Butler, Duncan J.3, Häusermann, Daniel1, Adam, Jean François4 |
| Source: | Medical Physics. Jul2016, Vol. 43 Issue 7, p4283-4293. 11p. |
| Subjects: | Single crystals, Diamonds, Radiotherapy, Synchrotrons, Therapeutic use of x-rays, Therapeutics |
| Abstract: | Purpose: Modern radiotherapy modalities often use small or nonstandard fields to ensure highly localized and precise dose delivery, challenging conventional clinical dosimetry protocols. The emergence of preclinical spatially fractionated synchrotron radiotherapies with high dose-rate, submillimetric parallel kilovoltage x-ray beams, has pushed clinical dosimetry to its limit. A commercially available synthetic single crystal diamond detector designed for small field dosimetry has been characterized to assess its potential as a dosimeter for synchrotron microbeam and minibeam radiotherapy. Methods: Experiments were carried out using a synthetic diamond detector on the imaging and medical beamline (IMBL) at the Australian Synchrotron. The energy dependence of the detector was characterized by cross-referencing with a calibrated ionization chamber in monoenergetic beams in the energy range 30-120 keV. The dose-rate dependence was measured in the range 1-700 Gy/s. Dosimetric quantities were measured in filtered white beams, with a weighted mean energy of 95 keV, in broadbeam and spatially fractionated geometries, and compared to reference dosimeters. Results: The detector exhibits an energy dependence; however, beam quality correction factors (kQ) have been measured for energies in the range 30-120 keV. The kQ factor for the weighted mean energy of the IMBL radiotherapy spectrum, 95 keV, is 1.05±0.09. The detector response is independent of dose-rate in the range 1-700 Gy/s. The percentage depth dose curves measured by the diamond detector were compared to ionization chambers and agreed to within 2%. Profile measurements of microbeam and minibeam arrays were performed. The beams are well resolved and the full width at halfmaximum agrees with the nominal width of the beams. The peak to valley dose ratio (PVDR) calculated from the profiles at various depths in water agrees within experimental error with PVDR calculations from Gafchromic film data. Conclusions: The synthetic diamond detector is now well characterized and will be used to develop an experimental dosimetry protocol for spatially fractionated synchrotron radiotherapy. [ABSTRACT FROM AUTHOR] |
| Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Items | – Name: Title Label: Title Group: Ti Data: Characterization of a synthetic single crystal diamond detector for dosimetry in spatially fractionated synchrotron x-ray fields. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Livingstone%2C+Jayde%22">Livingstone, Jayde</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Stevenson%2C+Andrew+W%2E%22">Stevenson, Andrew W.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Butler%2C+Duncan+J%2E%22">Butler, Duncan J.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Häusermann%2C+Daniel%22">Häusermann, Daniel</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Adam%2C+Jean+François%22">Adam, Jean François</searchLink><relatesTo>4</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Medical+Physics%22">Medical Physics</searchLink>. Jul2016, Vol. 43 Issue 7, p4283-4293. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Single+crystals%22">Single crystals</searchLink><br /><searchLink fieldCode="DE" term="%22Diamonds%22">Diamonds</searchLink><br /><searchLink fieldCode="DE" term="%22Radiotherapy%22">Radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Synchrotrons%22">Synchrotrons</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutic+use+of+x-rays%22">Therapeutic use of x-rays</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: Modern radiotherapy modalities often use small or nonstandard fields to ensure highly localized and precise dose delivery, challenging conventional clinical dosimetry protocols. The emergence of preclinical spatially fractionated synchrotron radiotherapies with high dose-rate, submillimetric parallel kilovoltage x-ray beams, has pushed clinical dosimetry to its limit. A commercially available synthetic single crystal diamond detector designed for small field dosimetry has been characterized to assess its potential as a dosimeter for synchrotron microbeam and minibeam radiotherapy. Methods: Experiments were carried out using a synthetic diamond detector on the imaging and medical beamline (IMBL) at the Australian Synchrotron. The energy dependence of the detector was characterized by cross-referencing with a calibrated ionization chamber in monoenergetic beams in the energy range 30-120 keV. The dose-rate dependence was measured in the range 1-700 Gy/s. Dosimetric quantities were measured in filtered white beams, with a weighted mean energy of 95 keV, in broadbeam and spatially fractionated geometries, and compared to reference dosimeters. Results: The detector exhibits an energy dependence; however, beam quality correction factors (kQ) have been measured for energies in the range 30-120 keV. The kQ factor for the weighted mean energy of the IMBL radiotherapy spectrum, 95 keV, is 1.05±0.09. The detector response is independent of dose-rate in the range 1-700 Gy/s. The percentage depth dose curves measured by the diamond detector were compared to ionization chambers and agreed to within 2%. Profile measurements of microbeam and minibeam arrays were performed. The beams are well resolved and the full width at halfmaximum agrees with the nominal width of the beams. The peak to valley dose ratio (PVDR) calculated from the profiles at various depths in water agrees within experimental error with PVDR calculations from Gafchromic film data. Conclusions: The synthetic diamond detector is now well characterized and will be used to develop an experimental dosimetry protocol for spatially fractionated synchrotron radiotherapy. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Medical Physics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1118/1.4953833 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 4283 Subjects: – SubjectFull: Single crystals Type: general – SubjectFull: Diamonds Type: general – SubjectFull: Radiotherapy Type: general – SubjectFull: Synchrotrons Type: general – SubjectFull: Therapeutic use of x-rays Type: general – SubjectFull: Therapeutics Type: general Titles: – TitleFull: Characterization of a synthetic single crystal diamond detector for dosimetry in spatially fractionated synchrotron x-ray fields. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Livingstone, Jayde – PersonEntity: Name: NameFull: Stevenson, Andrew W. – PersonEntity: Name: NameFull: Butler, Duncan J. – PersonEntity: Name: NameFull: Häusermann, Daniel – PersonEntity: Name: NameFull: Adam, Jean François IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2016 Type: published Y: 2016 Identifiers: – Type: issn-print Value: 00942405 Numbering: – Type: volume Value: 43 – Type: issue Value: 7 Titles: – TitleFull: Medical Physics Type: main |
| ResultId | 1 |
