Candida utilis and Cyberlindnera ( Pichia) jadinii: yeast relatives with expanding applications.
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| Title: | Candida utilis and Cyberlindnera ( Pichia) jadinii: yeast relatives with expanding applications. |
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| Authors: | Buerth, Christoph1, Tielker, Denis2, Ernst, Joachim1 joachim.ernst@uni-duesseldorf.de |
| Source: | Applied Microbiology & Biotechnology. Aug2016, Vol. 100 Issue 16, p6981-6990. 10p. |
| Subjects: | Candida utilis, Pichia, Recombinant proteins, Fungal cell walls, Laboratory mice |
| Abstract: | The yeast Candida utilis is used as a food additive and as a host for heterologous gene expression to produce various metabolites and proteins. Reliable protocols for intracellular production of recombinant proteins are available for C. utilis and have now been expanded to secrete proteins into the growth medium or to achieve surface display by linkage to a cell wall protein. A recombinant C. utilis strain was recently shown to induce oral tolerance in a mouse model of multiple sclerosis suggesting future applications in autoimmune therapy. Whole genome sequencing of C. utilis and its presumed parent Cyberlindnera ( Pichia) jadinii demonstrated different ploidy but high sequence identity, consistent with identical recombinant technologies for both yeasts. C. jadinii was recently described as an antagonist to the important human fungal pathogen Candida albicans suggesting its use as a probiotic agent. The review summarizes the status of recombinant protein production in C. utilis, as well as current and future biotechnological and medical applications of C. utilis and C. jadinii. [ABSTRACT FROM AUTHOR] |
| Copyright of Applied Microbiology & Biotechnology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 116859700 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Candida utilis and Cyberlindnera ( Pichia) jadinii: yeast relatives with expanding applications. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Buerth%2C+Christoph%22">Buerth, Christoph</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Tielker%2C+Denis%22">Tielker, Denis</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Ernst%2C+Joachim%22">Ernst, Joachim</searchLink><relatesTo>1</relatesTo><i> joachim.ernst@uni-duesseldorf.de</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Applied+Microbiology+%26+Biotechnology%22">Applied Microbiology & Biotechnology</searchLink>. Aug2016, Vol. 100 Issue 16, p6981-6990. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Candida+utilis%22">Candida utilis</searchLink><br /><searchLink fieldCode="DE" term="%22Pichia%22">Pichia</searchLink><br /><searchLink fieldCode="DE" term="%22Recombinant+proteins%22">Recombinant proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Fungal+cell+walls%22">Fungal cell walls</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+mice%22">Laboratory mice</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The yeast Candida utilis is used as a food additive and as a host for heterologous gene expression to produce various metabolites and proteins. Reliable protocols for intracellular production of recombinant proteins are available for C. utilis and have now been expanded to secrete proteins into the growth medium or to achieve surface display by linkage to a cell wall protein. A recombinant C. utilis strain was recently shown to induce oral tolerance in a mouse model of multiple sclerosis suggesting future applications in autoimmune therapy. Whole genome sequencing of C. utilis and its presumed parent Cyberlindnera ( Pichia) jadinii demonstrated different ploidy but high sequence identity, consistent with identical recombinant technologies for both yeasts. C. jadinii was recently described as an antagonist to the important human fungal pathogen Candida albicans suggesting its use as a probiotic agent. The review summarizes the status of recombinant protein production in C. utilis, as well as current and future biotechnological and medical applications of C. utilis and C. jadinii. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Applied Microbiology & Biotechnology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00253-016-7700-8 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 6981 Subjects: – SubjectFull: Candida utilis Type: general – SubjectFull: Pichia Type: general – SubjectFull: Recombinant proteins Type: general – SubjectFull: Fungal cell walls Type: general – SubjectFull: Laboratory mice Type: general Titles: – TitleFull: Candida utilis and Cyberlindnera ( Pichia) jadinii: yeast relatives with expanding applications. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Buerth, Christoph – PersonEntity: Name: NameFull: Tielker, Denis – PersonEntity: Name: NameFull: Ernst, Joachim IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 08 Text: Aug2016 Type: published Y: 2016 Identifiers: – Type: issn-print Value: 01757598 Numbering: – Type: volume Value: 100 – Type: issue Value: 16 Titles: – TitleFull: Applied Microbiology & Biotechnology Type: main |
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