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Modified glycogen as construction material for functional biomimetic microfibers.

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Title: Modified glycogen as construction material for functional biomimetic microfibers.
Authors: Rabyk, Mariia1 rabyk@imc.cas.cz, Hruby, Martin1 hruby@imc.cas.cz, Vetrik, Miroslav1 vetrix@seznam.cz, Kucka, Jan1 jkucka@centrum.cz, Proks, Vladimir1 proks@imc.cas.cz, Parizek, Martin2 parizek@biomed.cas.cz, Konefal, Rafal1 konefal@imc.cas.cz, Krist, Pavel3 krist@ujf.cas.cz, Chvatil, David3 chvatil@ujf.cas.cz, Bacakova, Lucie2 lucy@biomed.cas.cz, Slouf, Miroslav1 slouf@imc.cas.cz, Stepanek, Petr1 stepan@imc.cas.cz
Source: Carbohydrate Polymers. Nov2016, Vol. 152, p271-279. 9p.
Subjects: Glycogen, Construction materials, Biomimetic materials, Wound healing, Allylation
Abstract: We describe a conceptually new, microfibrous, biodegradable functional material prepared from a modified storage polysaccharide also present in humans (glycogen) showing strong potential as direct-contact dressing/interface material for wound healing. Double bonds were introduced into glycogen via allylation and were further exploited for crosslinking of the microfibers. Triple bonds were introduced by propargylation and served for further click functionalization of the microfibers with bioactive peptide. A simple solvent-free method allowing the preparation of thick layers was used to produce microfibers (diameter ca 2 μm) from allylated and/or propargylated glycogen. Crosslinking of the samples was performed by microtron beta-irradiation, and the irradiation dose was optimized to 2 kGy. The results from biological testing showed that these highly porous, hydrophilic, readily functionalizable materials were completely nontoxic to cells growing in their presence. The fibers were gradually degraded in the presence of cells. [ABSTRACT FROM AUTHOR]
Copyright of Carbohydrate Polymers is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
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DbLabel: Engineering Source
An: 117317569
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Modified glycogen as construction material for functional biomimetic microfibers.
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  Data: <searchLink fieldCode="AR" term="%22Rabyk%2C+Mariia%22">Rabyk, Mariia</searchLink><relatesTo>1</relatesTo><i> rabyk@imc.cas.cz</i><br /><searchLink fieldCode="AR" term="%22Hruby%2C+Martin%22">Hruby, Martin</searchLink><relatesTo>1</relatesTo><i> hruby@imc.cas.cz</i><br /><searchLink fieldCode="AR" term="%22Vetrik%2C+Miroslav%22">Vetrik, Miroslav</searchLink><relatesTo>1</relatesTo><i> vetrix@seznam.cz</i><br /><searchLink fieldCode="AR" term="%22Kucka%2C+Jan%22">Kucka, Jan</searchLink><relatesTo>1</relatesTo><i> jkucka@centrum.cz</i><br /><searchLink fieldCode="AR" term="%22Proks%2C+Vladimir%22">Proks, Vladimir</searchLink><relatesTo>1</relatesTo><i> proks@imc.cas.cz</i><br /><searchLink fieldCode="AR" term="%22Parizek%2C+Martin%22">Parizek, Martin</searchLink><relatesTo>2</relatesTo><i> parizek@biomed.cas.cz</i><br /><searchLink fieldCode="AR" term="%22Konefal%2C+Rafal%22">Konefal, Rafal</searchLink><relatesTo>1</relatesTo><i> konefal@imc.cas.cz</i><br /><searchLink fieldCode="AR" term="%22Krist%2C+Pavel%22">Krist, Pavel</searchLink><relatesTo>3</relatesTo><i> krist@ujf.cas.cz</i><br /><searchLink fieldCode="AR" term="%22Chvatil%2C+David%22">Chvatil, David</searchLink><relatesTo>3</relatesTo><i> chvatil@ujf.cas.cz</i><br /><searchLink fieldCode="AR" term="%22Bacakova%2C+Lucie%22">Bacakova, Lucie</searchLink><relatesTo>2</relatesTo><i> lucy@biomed.cas.cz</i><br /><searchLink fieldCode="AR" term="%22Slouf%2C+Miroslav%22">Slouf, Miroslav</searchLink><relatesTo>1</relatesTo><i> slouf@imc.cas.cz</i><br /><searchLink fieldCode="AR" term="%22Stepanek%2C+Petr%22">Stepanek, Petr</searchLink><relatesTo>1</relatesTo><i> stepan@imc.cas.cz</i>
– Name: TitleSource
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  Data: <searchLink fieldCode="JN" term="%22Carbohydrate+Polymers%22">Carbohydrate Polymers</searchLink>. Nov2016, Vol. 152, p271-279. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Glycogen%22">Glycogen</searchLink><br /><searchLink fieldCode="DE" term="%22Construction+materials%22">Construction materials</searchLink><br /><searchLink fieldCode="DE" term="%22Biomimetic+materials%22">Biomimetic materials</searchLink><br /><searchLink fieldCode="DE" term="%22Wound+healing%22">Wound healing</searchLink><br /><searchLink fieldCode="DE" term="%22Allylation%22">Allylation</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: We describe a conceptually new, microfibrous, biodegradable functional material prepared from a modified storage polysaccharide also present in humans (glycogen) showing strong potential as direct-contact dressing/interface material for wound healing. Double bonds were introduced into glycogen via allylation and were further exploited for crosslinking of the microfibers. Triple bonds were introduced by propargylation and served for further click functionalization of the microfibers with bioactive peptide. A simple solvent-free method allowing the preparation of thick layers was used to produce microfibers (diameter ca 2 μm) from allylated and/or propargylated glycogen. Crosslinking of the samples was performed by microtron beta-irradiation, and the irradiation dose was optimized to 2 kGy. The results from biological testing showed that these highly porous, hydrophilic, readily functionalizable materials were completely nontoxic to cells growing in their presence. The fibers were gradually degraded in the presence of cells. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Carbohydrate Polymers is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=117317569
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.carbpol.2016.06.107
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 271
    Subjects:
      – SubjectFull: Glycogen
        Type: general
      – SubjectFull: Construction materials
        Type: general
      – SubjectFull: Biomimetic materials
        Type: general
      – SubjectFull: Wound healing
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      – SubjectFull: Allylation
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      – TitleFull: Modified glycogen as construction material for functional biomimetic microfibers.
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              Text: Nov2016
              Type: published
              Y: 2016
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