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Evolutionary theory of ageing and the problem of correlated Gompertz parameters.

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Title: Evolutionary theory of ageing and the problem of correlated Gompertz parameters.
Authors: Burger, Oskar1 ofb@kent.ac.uk, Missov, Trifon I.1,2
Source: Journal of Theoretical Biology. Nov2016, Vol. 408, p34-41. 8p.
Subjects: Biological evolution, Aging, Mortality, Gompertz functions (Mathematics), Inverse relationships (Mathematics)
Abstract: The Gompertz mortality model is often used to evaluate evolutionary theories of ageing, such as the Medawar–Williams' hypothesis that high extrinsic mortality leads to faster ageing. However, fits of the Gompertz mortality model to data often find the opposite result that mortality is negatively correlated with the rate of ageing. This negative correlation has been independently discovered in several taxa and is known in actuarial studies of ageing as the Strehler–Mildvan correlation. We examine the role of mortality selection in determining late-life variation in susceptibility to death, which has been suggested to be the cause of this negative correlation. We demonstrate that fixed-frailty models that account for heterogeneity in frailty do not remove the correlation and that the correlation is an inherent statistical property of the Gompertz distribution. Linking actuarial and biological rates of ageing will continue to be a pressing challenge, but the Strehler–Mildvan correlation itself should not be used to diagnose any biological, physiological, or evolutionary process. These findings resolve some key tensions between theory and data that affect evolutionary and biological studies of ageing and mortality. Tests of evolutionary theories of ageing should include direct measures of physiological performance or condition. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Theoretical Biology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Evolutionary theory of ageing and the problem of correlated Gompertz parameters.
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  Data: <searchLink fieldCode="DE" term="%22Biological+evolution%22">Biological evolution</searchLink><br /><searchLink fieldCode="DE" term="%22Aging%22">Aging</searchLink><br /><searchLink fieldCode="DE" term="%22Mortality%22">Mortality</searchLink><br /><searchLink fieldCode="DE" term="%22Gompertz+functions+%28Mathematics%29%22">Gompertz functions (Mathematics)</searchLink><br /><searchLink fieldCode="DE" term="%22Inverse+relationships+%28Mathematics%29%22">Inverse relationships (Mathematics)</searchLink>
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  Data: The Gompertz mortality model is often used to evaluate evolutionary theories of ageing, such as the Medawar–Williams' hypothesis that high extrinsic mortality leads to faster ageing. However, fits of the Gompertz mortality model to data often find the opposite result that mortality is negatively correlated with the rate of ageing. This negative correlation has been independently discovered in several taxa and is known in actuarial studies of ageing as the Strehler–Mildvan correlation. We examine the role of mortality selection in determining late-life variation in susceptibility to death, which has been suggested to be the cause of this negative correlation. We demonstrate that fixed-frailty models that account for heterogeneity in frailty do not remove the correlation and that the correlation is an inherent statistical property of the Gompertz distribution. Linking actuarial and biological rates of ageing will continue to be a pressing challenge, but the Strehler–Mildvan correlation itself should not be used to diagnose any biological, physiological, or evolutionary process. These findings resolve some key tensions between theory and data that affect evolutionary and biological studies of ageing and mortality. Tests of evolutionary theories of ageing should include direct measures of physiological performance or condition. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Theoretical Biology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.jtbi.2016.08.002
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      – Code: eng
        Text: English
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        PageCount: 8
        StartPage: 34
    Subjects:
      – SubjectFull: Biological evolution
        Type: general
      – SubjectFull: Aging
        Type: general
      – SubjectFull: Mortality
        Type: general
      – SubjectFull: Gompertz functions (Mathematics)
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      – SubjectFull: Inverse relationships (Mathematics)
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      – TitleFull: Evolutionary theory of ageing and the problem of correlated Gompertz parameters.
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              Text: Nov2016
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