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Spectroscopic and calorimetric studies on the interaction between PAMAM G4-OH and 5-fluorouracil in aqueous solutions.

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Title: Spectroscopic and calorimetric studies on the interaction between PAMAM G4-OH and 5-fluorouracil in aqueous solutions.
Authors: Buczkowski, Adam1 buczkowski_adam@tlen.pl, Urbaniak, Pawel2, Piekarski, Henryk1, Palecz, Bartlomiej1 paleczb@uni.lodz.pl
Source: Spectrochimica Acta Part A: Molecular & Biomolecular Spectroscopy. Jan2017, Vol. 171, p401-405. 5p.
Subjects: Calorimetry, Aqueous solutions, Fluorouracil, Hydroxyl group, Nuclear magnetic resonance spectroscopy
Abstract: The results of spectroscopic measurements (an increase in solubility, equilibrium dialysis, 1 H NMR titration) and calorimetric measurements (isothermal titration ITC) indicate spontaneous ( ΔG < 0) binding of 5-fluorouracil molecules by PAMAM G4-OH dendrimer with terminal hydroxyl groups in an aqueous solution. PAMAM G4-OH dendrimer bonds about n = 8 ± 1 molecules of the drug with an equilibrium constant of K = 70 ± 10. The process of saturating the dendrimer active sites by the drug molecules is exothermal ( ΔH < 0) and is accompanied by an advantageous change in entropy ( ΔS > 0). The parameters of binding 5-fluorouracil by PAMAM G4-OH dendrimer were compared with those of binding this drug by the macromolecules of PAMAM G3-OH and G5-OH. [ABSTRACT FROM AUTHOR]
Copyright of Spectrochimica Acta Part A: Molecular & Biomolecular Spectroscopy is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Text:
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DbLabel: Engineering Source
An: 118470226
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Spectroscopic and calorimetric studies on the interaction between PAMAM G4-OH and 5-fluorouracil in aqueous solutions.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Calorimetry%22&quot;&gt;Calorimetry&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Aqueous+solutions%22&quot;&gt;Aqueous solutions&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Fluorouracil%22&quot;&gt;Fluorouracil&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Hydroxyl+group%22&quot;&gt;Hydroxyl group&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Nuclear+magnetic+resonance+spectroscopy%22&quot;&gt;Nuclear magnetic resonance spectroscopy&lt;/searchLink&gt;
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  Data: The results of spectroscopic measurements (an increase in solubility, equilibrium dialysis, 1 H NMR titration) and calorimetric measurements (isothermal titration ITC) indicate spontaneous ( ΔG &lt; 0) binding of 5-fluorouracil molecules by PAMAM G4-OH dendrimer with terminal hydroxyl groups in an aqueous solution. PAMAM G4-OH dendrimer bonds about n = 8 &#177; 1 molecules of the drug with an equilibrium constant of K = 70 &#177; 10. The process of saturating the dendrimer active sites by the drug molecules is exothermal ( ΔH &lt; 0) and is accompanied by an advantageous change in entropy ( ΔS &gt; 0). The parameters of binding 5-fluorouracil by PAMAM G4-OH dendrimer were compared with those of binding this drug by the macromolecules of PAMAM G3-OH and G5-OH. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Spectrochimica Acta Part A: Molecular &amp; Biomolecular Spectroscopy is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.saa.2016.08.030
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      – Code: eng
        Text: English
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        PageCount: 5
        StartPage: 401
    Subjects:
      – SubjectFull: Calorimetry
        Type: general
      – SubjectFull: Aqueous solutions
        Type: general
      – SubjectFull: Fluorouracil
        Type: general
      – SubjectFull: Hydroxyl group
        Type: general
      – SubjectFull: Nuclear magnetic resonance spectroscopy
        Type: general
    Titles:
      – TitleFull: Spectroscopic and calorimetric studies on the interaction between PAMAM G4-OH and 5-fluorouracil in aqueous solutions.
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            NameFull: Buczkowski, Adam
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            NameFull: Urbaniak, Pawel
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            NameFull: Piekarski, Henryk
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            NameFull: Palecz, Bartlomiej
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            – D: 15
              M: 01
              Text: Jan2017
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              Y: 2017
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              Value: 171
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            – TitleFull: Spectrochimica Acta Part A: Molecular & Biomolecular Spectroscopy
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