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Temoporfin-loaded 1-tetradecanol-based thermoresponsive solid lipid nanoparticles for photodynamic therapy.

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Title: Temoporfin-loaded 1-tetradecanol-based thermoresponsive solid lipid nanoparticles for photodynamic therapy.
Authors: Brezaniova, Ingrid1, Hruby, Martin2 mhruby@centrum.cz, Kralova, Jarmila3, Kral, Vladimir1, Cernochova, Zulfiya2, Cernoch, Peter2, Slouf, Miroslav2, Kredatusova, Jana2, Stepanek, Petr2
Source: Journal of Controlled Release. Nov2016, Vol. 241, p34-44. 11p.
Subjects: Tetradecane, Thermoresponsive polymers, Lipid nanotubes, Photodynamic therapy, Biodegradable nanoparticles
Abstract: We developed fully biodegradable/metabolizable nanosystem based on polymer surfactant-stabilized thermoresponsive solid lipid nanoparticles with non-covalently bound photosensitizer temoporfin (T-SLNP) with particle size below 50 nm. The efficacy of T-SLNP was compared with commercial temoporfin formulation in terms of in vitro phototoxicity in 4T1 (murine mammary carcinoma) and MDA-MB-231(human breast adenocarcinoma) cells and of in vivo anticancer effect in Nu/Nu mice bearing MDA-MB-231 tumors . In vitro study demonstrated faster accumulation kinetics in the cells for our formulation design resulting in higher phototoxicity against the tumor cells. In vivo anticancer efficacy was markedly improved by T-SLNP compared with commercial temoporfin formulation. Owing to controlled and sustained release properties, subcellular size, biocompatibility with tissue and cells, the T-SLNP nanodispersion prepared in this study represents promising drug delivery system applicable in cancer treatment. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 118849140
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Label: Title
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  Data: Temoporfin-loaded 1-tetradecanol-based thermoresponsive solid lipid nanoparticles for photodynamic therapy.
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  Data: <searchLink fieldCode="AR" term="%22Brezaniova%2C+Ingrid%22">Brezaniova, Ingrid</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hruby%2C+Martin%22">Hruby, Martin</searchLink><relatesTo>2</relatesTo><i> mhruby@centrum.cz</i><br /><searchLink fieldCode="AR" term="%22Kralova%2C+Jarmila%22">Kralova, Jarmila</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Kral%2C+Vladimir%22">Kral, Vladimir</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Cernochova%2C+Zulfiya%22">Cernochova, Zulfiya</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Cernoch%2C+Peter%22">Cernoch, Peter</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Slouf%2C+Miroslav%22">Slouf, Miroslav</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Kredatusova%2C+Jana%22">Kredatusova, Jana</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Stepanek%2C+Petr%22">Stepanek, Petr</searchLink><relatesTo>2</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Controlled+Release%22">Journal of Controlled Release</searchLink>. Nov2016, Vol. 241, p34-44. 11p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Tetradecane%22">Tetradecane</searchLink><br /><searchLink fieldCode="DE" term="%22Thermoresponsive+polymers%22">Thermoresponsive polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Lipid+nanotubes%22">Lipid nanotubes</searchLink><br /><searchLink fieldCode="DE" term="%22Photodynamic+therapy%22">Photodynamic therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Biodegradable+nanoparticles%22">Biodegradable nanoparticles</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: We developed fully biodegradable/metabolizable nanosystem based on polymer surfactant-stabilized thermoresponsive solid lipid nanoparticles with non-covalently bound photosensitizer temoporfin (T-SLNP) with particle size below 50 nm. The efficacy of T-SLNP was compared with commercial temoporfin formulation in terms of in vitro phototoxicity in 4T1 (murine mammary carcinoma) and MDA-MB-231(human breast adenocarcinoma) cells and of in vivo anticancer effect in Nu/Nu mice bearing MDA-MB-231 tumors . In vitro study demonstrated faster accumulation kinetics in the cells for our formulation design resulting in higher phototoxicity against the tumor cells. In vivo anticancer efficacy was markedly improved by T-SLNP compared with commercial temoporfin formulation. Owing to controlled and sustained release properties, subcellular size, biocompatibility with tissue and cells, the T-SLNP nanodispersion prepared in this study represents promising drug delivery system applicable in cancer treatment. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.jconrel.2016.09.009
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 11
        StartPage: 34
    Subjects:
      – SubjectFull: Tetradecane
        Type: general
      – SubjectFull: Thermoresponsive polymers
        Type: general
      – SubjectFull: Lipid nanotubes
        Type: general
      – SubjectFull: Photodynamic therapy
        Type: general
      – SubjectFull: Biodegradable nanoparticles
        Type: general
    Titles:
      – TitleFull: Temoporfin-loaded 1-tetradecanol-based thermoresponsive solid lipid nanoparticles for photodynamic therapy.
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            NameFull: Brezaniova, Ingrid
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            NameFull: Hruby, Martin
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            NameFull: Kralova, Jarmila
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              M: 11
              Text: Nov2016
              Type: published
              Y: 2016
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            – Type: issn-print
              Value: 01683659
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              Value: 241
          Titles:
            – TitleFull: Journal of Controlled Release
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