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Recent Developments in Microwave-Assisted Metal-Catalyzed C-H Functionalization of Heteroarenes for Medicinal Chemistry and Material Applications.

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Title: Recent Developments in Microwave-Assisted Metal-Catalyzed C-H Functionalization of Heteroarenes for Medicinal Chemistry and Material Applications.
Authors: Besson, Thierry1, Fruit, Corinne1 corinne.fruit@univ-rouen.fr
Source: Synthesis. 2016, Vol. 48 Issue 22, p3879-3889. 11p.
Subjects: Carbon, Activation (Chemistry), Pharmaceutical chemistry, Irradiation, Microwave heating
Abstract: C-C Bond formation from direct C-H activation is now recognized as a powerful and straightforward strategy for the synthesis of complex molecules and especially for late-stage functionalization. Many of these reactions allow a streamlined route to bi(hetero)aryl compounds with applications in medicinal chemistry as well as in organic materials. Since high temperatures and long reaction times are often required for C-H activation, microwave irradiation has emerged as a suitable tool. This short review gives an overview of the metal-catalyzed C-H functionalization of heteroarenes since 2013 and highlights the benefits of microwave irradiation over traditional heating. 1 Introduction 2 Palladium-Catalyzed Direct Functionalization of sp² C-H Bonds with Aryl Halides 3 Palladium-Catalyzed and Silver-Assisted Direct Arylation of sp² C-H Bonds with Aryl Halides 4 Palladium-Catalyzed and Copper-Assisted Direct Arylation of sp² C-H Bonds with Aryl Halides 5 Copper-Catalyzed sp³-sp² C-C Bond Formation 6 Conclusion [ABSTRACT FROM AUTHOR]
Copyright of Synthesis is the property of Georg Thieme Verlag Stuttgart and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 119129272
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PubType: Academic Journal
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  Data: Recent Developments in Microwave-Assisted Metal-Catalyzed C-H Functionalization of Heteroarenes for Medicinal Chemistry and Material Applications.
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  Data: <searchLink fieldCode="AR" term="%22Besson%2C+Thierry%22">Besson, Thierry</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Fruit%2C+Corinne%22">Fruit, Corinne</searchLink><relatesTo>1</relatesTo><i> corinne.fruit@univ-rouen.fr</i>
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  Data: <searchLink fieldCode="JN" term="%22Synthesis%22">Synthesis</searchLink>. 2016, Vol. 48 Issue 22, p3879-3889. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Carbon%22">Carbon</searchLink><br /><searchLink fieldCode="DE" term="%22Activation+%28Chemistry%29%22">Activation (Chemistry)</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmaceutical+chemistry%22">Pharmaceutical chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Irradiation%22">Irradiation</searchLink><br /><searchLink fieldCode="DE" term="%22Microwave+heating%22">Microwave heating</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: C-C Bond formation from direct C-H activation is now recognized as a powerful and straightforward strategy for the synthesis of complex molecules and especially for late-stage functionalization. Many of these reactions allow a streamlined route to bi(hetero)aryl compounds with applications in medicinal chemistry as well as in organic materials. Since high temperatures and long reaction times are often required for C-H activation, microwave irradiation has emerged as a suitable tool. This short review gives an overview of the metal-catalyzed C-H functionalization of heteroarenes since 2013 and highlights the benefits of microwave irradiation over traditional heating. 1 Introduction 2 Palladium-Catalyzed Direct Functionalization of sp² C-H Bonds with Aryl Halides 3 Palladium-Catalyzed and Silver-Assisted Direct Arylation of sp² C-H Bonds with Aryl Halides 4 Palladium-Catalyzed and Copper-Assisted Direct Arylation of sp² C-H Bonds with Aryl Halides 5 Copper-Catalyzed sp³-sp² C-C Bond Formation 6 Conclusion [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Synthesis is the property of Georg Thieme Verlag Stuttgart and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1055/s-0035-1562608
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      – Code: eng
        Text: English
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        PageCount: 11
        StartPage: 3879
    Subjects:
      – SubjectFull: Carbon
        Type: general
      – SubjectFull: Activation (Chemistry)
        Type: general
      – SubjectFull: Pharmaceutical chemistry
        Type: general
      – SubjectFull: Irradiation
        Type: general
      – SubjectFull: Microwave heating
        Type: general
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      – TitleFull: Recent Developments in Microwave-Assisted Metal-Catalyzed C-H Functionalization of Heteroarenes for Medicinal Chemistry and Material Applications.
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              Text: 2016
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              Value: 48
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