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The development of bronchiectasis on chest computed tomography in children with cystic fibrosis: can pre-stages be identified?

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Title: The development of bronchiectasis on chest computed tomography in children with cystic fibrosis: can pre-stages be identified?
Authors: Tepper, Leonie, Rovira, Adria, Tiddens, Harm, Bruijne, Marleen, Caudri, Daan1, Tepper, Leonie A2,3 (AUTHOR), Rovira, Adria Perez2,4 (AUTHOR), Tiddens, Harm A W M2,3,5 (AUTHOR), de Bruijne, Marleen4,6 (AUTHOR)
Source: European Radiology. Dec2016, Vol. 26 Issue 12, p4563-4569. 7p. 1 Color Photograph, 1 Diagram, 1 Chart, 1 Graph.
Subjects: Bronchiectasis, Computed tomography, Cystic fibrosis in children, Lung diseases, Mucus, Pneumothorax, Diagnosis, Cystic fibrosis, Longitudinal method, Lungs, Research bias, Retrospective studies, Disease progression, Disease complications
Abstract: Objective: Bronchiectasis is an important component of cystic fibrosis (CF) lung disease but little is known about its development. We aimed to study the development of bronchiectasis and identify determinants for rapid progression of bronchiectasis on chest CT.Methods: Forty-three patients with CF with at least four consecutive biennial volumetric CTs were included. Areas with bronchiectasis on the most recent CT were marked as regions of interest (ROIs). These ROIs were generated on all preceding CTs using deformable image registration. Observers indicated whether: bronchiectasis, mucus plugging, airway wall thickening, atelectasis/consolidation or normal airways were present in the ROIs.Results: We identified 362 ROIs on the most recent CT. In 187 (51.7 %) ROIs bronchiectasis was present on all preceding CTs, while 175 ROIs showed development of bronchiectasis. In 139/175 (79.4 %) no pre-stages of bronchiectasis were identified. In 36/175 (20.6 %) bronchiectatic airways the following pre-stages were identified: mucus plugging (17.7 %), airway wall thickening (1.7 %) or atelectasis/consolidation (1.1 %). Pancreatic insufficiency was more prevalent in the rapid progressors compared to the slow progressors (p = 0.05).Conclusion: Most bronchiectatic airways developed within 2 years without visible pre-stages, underlining the treacherous nature of CF lung disease. Mucus plugging was the most frequent pre-stage.Key Points: • Development of bronchiectasis in cystic fibrosis lung disease on CT. • Most bronchiectatic airways developed within 2 years without pre-stages. • The most frequently identified pre-stage was mucus plugging. • This study underlines the treacherous nature of CF lung disease. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: The development of bronchiectasis on chest computed tomography in children with cystic fibrosis: can pre-stages be identified?
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  Data: <searchLink fieldCode="AR" term="%22Tepper%2C+Leonie%22">Tepper, Leonie</searchLink><br /><searchLink fieldCode="AR" term="%22Rovira%2C+Adria%22">Rovira, Adria</searchLink><br /><searchLink fieldCode="AR" term="%22Tiddens%2C+Harm%22">Tiddens, Harm</searchLink><br /><searchLink fieldCode="AR" term="%22Bruijne%2C+Marleen%22">Bruijne, Marleen</searchLink><br /><searchLink fieldCode="AR" term="%22Caudri%2C+Daan%22">Caudri, Daan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Tepper%2C+Leonie+A%22">Tepper, Leonie A</searchLink><relatesTo>2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rovira%2C+Adria+Perez%22">Rovira, Adria Perez</searchLink><relatesTo>2,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tiddens%2C+Harm+A+W+M%22">Tiddens, Harm A W M</searchLink><relatesTo>2,3,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Bruijne%2C+Marleen%22">de Bruijne, Marleen</searchLink><relatesTo>4,6</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Dec2016, Vol. 26 Issue 12, p4563-4569. 7p. 1 Color Photograph, 1 Diagram, 1 Chart, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Bronchiectasis%22">Bronchiectasis</searchLink><br /><searchLink fieldCode="DE" term="%22Computed+tomography%22">Computed tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Cystic+fibrosis+in+children%22">Cystic fibrosis in children</searchLink><br /><searchLink fieldCode="DE" term="%22Lung+diseases%22">Lung diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Mucus%22">Mucus</searchLink><br /><searchLink fieldCode="DE" term="%22Pneumothorax%22">Pneumothorax</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis%22">Diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Cystic+fibrosis%22">Cystic fibrosis</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Lungs%22">Lungs</searchLink><br /><searchLink fieldCode="DE" term="%22Research+bias%22">Research bias</searchLink><br /><searchLink fieldCode="DE" term="%22Retrospective+studies%22">Retrospective studies</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+progression%22">Disease progression</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+complications%22">Disease complications</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: <bold>Objective: </bold>Bronchiectasis is an important component of cystic fibrosis (CF) lung disease but little is known about its development. We aimed to study the development of bronchiectasis and identify determinants for rapid progression of bronchiectasis on chest CT.<bold>Methods: </bold>Forty-three patients with CF with at least four consecutive biennial volumetric CTs were included. Areas with bronchiectasis on the most recent CT were marked as regions of interest (ROIs). These ROIs were generated on all preceding CTs using deformable image registration. Observers indicated whether: bronchiectasis, mucus plugging, airway wall thickening, atelectasis/consolidation or normal airways were present in the ROIs.<bold>Results: </bold>We identified 362 ROIs on the most recent CT. In 187 (51.7 %) ROIs bronchiectasis was present on all preceding CTs, while 175 ROIs showed development of bronchiectasis. In 139/175 (79.4 %) no pre-stages of bronchiectasis were identified. In 36/175 (20.6 %) bronchiectatic airways the following pre-stages were identified: mucus plugging (17.7 %), airway wall thickening (1.7 %) or atelectasis/consolidation (1.1 %). Pancreatic insufficiency was more prevalent in the rapid progressors compared to the slow progressors (p = 0.05).<bold>Conclusion: </bold>Most bronchiectatic airways developed within 2 years without visible pre-stages, underlining the treacherous nature of CF lung disease. Mucus plugging was the most frequent pre-stage.<bold>Key Points: </bold>• Development of bronchiectasis in cystic fibrosis lung disease on CT. • Most bronchiectatic airways developed within 2 years without pre-stages. • The most frequently identified pre-stage was mucus plugging. • This study underlines the treacherous nature of CF lung disease. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00330-016-4329-z
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      – SubjectFull: Cystic fibrosis in children
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              Text: Dec2016
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