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Physico-chemical characterization of succinyl chitosan-stabilized liposomes for the oral co-delivery of quercetin and resveratrol.

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Title: Physico-chemical characterization of succinyl chitosan-stabilized liposomes for the oral co-delivery of quercetin and resveratrol.
Authors: Caddeo, Carla1 caddeoc@unica.it, Pons, Ramon2, Carbone, Claudia3, Fernàndez-Busquets, Xavier4,5, Cardia, Maria Cristina1, Maccioni, Anna Maria1, Fadda, Anna Maria1, Manconi, Maria1
Source: Carbohydrate Polymers. Feb2017, Vol. 157, p1853-1861. 9p.
Subjects: Quercetin, Resveratrol, Liposomes, Antioxidants, Transmission electron microscopy
Abstract: In the present work, quercetin and resveratrol, natural polyphenols with strong antioxidant and anti-inflammatory properties, were co-loaded in polymer-associated liposomes conceived for oral delivery, by exploiting the potential of pH-sensitive succinyl-chitosan. Chitosan was succinylated, characterized by Nuclear Magnetic Resonance spectroscopy and Gel Permeation Chromatography, and used to form a protective shell on the surface of liposomes. The physico-chemical properties of the succinyl-chitosan liposomes were assessed by light scattering, zeta potential, cryogenic transmission electron microscopy, and small angle X-ray scattering. Small, spherical, uni- and bilamellar vesicles were produced. The succinyl-chitosan shell increased not only the physical stability of the vesicular system, as demonstrated by accelerated stability tests, but also the release of the polyphenols to a greater extent at pH 7.0, mimicking the intestinal environment. The proposed approach based on polyphenol vesicular formulations may be of value in the treatment of pre-cancerous/cancerous intestinal conditions associated with inflammation and oxidative stress. [ABSTRACT FROM AUTHOR]
Copyright of Carbohydrate Polymers is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 120226610
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Physico-chemical characterization of succinyl chitosan-stabilized liposomes for the oral co-delivery of quercetin and resveratrol.
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  Data: <searchLink fieldCode="AR" term="%22Caddeo%2C+Carla%22">Caddeo, Carla</searchLink><relatesTo>1</relatesTo><i> caddeoc@unica.it</i><br /><searchLink fieldCode="AR" term="%22Pons%2C+Ramon%22">Pons, Ramon</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Carbone%2C+Claudia%22">Carbone, Claudia</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Fernàndez-Busquets%2C+Xavier%22">Fernàndez-Busquets, Xavier</searchLink><relatesTo>4,5</relatesTo><br /><searchLink fieldCode="AR" term="%22Cardia%2C+Maria+Cristina%22">Cardia, Maria Cristina</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Maccioni%2C+Anna+Maria%22">Maccioni, Anna Maria</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Fadda%2C+Anna+Maria%22">Fadda, Anna Maria</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Manconi%2C+Maria%22">Manconi, Maria</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Carbohydrate+Polymers%22">Carbohydrate Polymers</searchLink>. Feb2017, Vol. 157, p1853-1861. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Quercetin%22">Quercetin</searchLink><br /><searchLink fieldCode="DE" term="%22Resveratrol%22">Resveratrol</searchLink><br /><searchLink fieldCode="DE" term="%22Liposomes%22">Liposomes</searchLink><br /><searchLink fieldCode="DE" term="%22Antioxidants%22">Antioxidants</searchLink><br /><searchLink fieldCode="DE" term="%22Transmission+electron+microscopy%22">Transmission electron microscopy</searchLink>
– Name: Abstract
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  Data: In the present work, quercetin and resveratrol, natural polyphenols with strong antioxidant and anti-inflammatory properties, were co-loaded in polymer-associated liposomes conceived for oral delivery, by exploiting the potential of pH-sensitive succinyl-chitosan. Chitosan was succinylated, characterized by Nuclear Magnetic Resonance spectroscopy and Gel Permeation Chromatography, and used to form a protective shell on the surface of liposomes. The physico-chemical properties of the succinyl-chitosan liposomes were assessed by light scattering, zeta potential, cryogenic transmission electron microscopy, and small angle X-ray scattering. Small, spherical, uni- and bilamellar vesicles were produced. The succinyl-chitosan shell increased not only the physical stability of the vesicular system, as demonstrated by accelerated stability tests, but also the release of the polyphenols to a greater extent at pH 7.0, mimicking the intestinal environment. The proposed approach based on polyphenol vesicular formulations may be of value in the treatment of pre-cancerous/cancerous intestinal conditions associated with inflammation and oxidative stress. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Carbohydrate Polymers is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.carbpol.2016.11.072
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        Type: general
      – SubjectFull: Resveratrol
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      – SubjectFull: Liposomes
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      – SubjectFull: Transmission electron microscopy
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              Text: Feb2017
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