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Dietary Tryptophan Enhanced the Expression of Tight Junction Protein ZO-1 in Intestine.

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Title: Dietary Tryptophan Enhanced the Expression of Tight Junction Protein ZO-1 in Intestine.
Authors: Liu, Wenhui1, Mi, Shumei1, Ruan, Zheng1 ruanzheng@ncu.edu.cn, Li, Jing1, Shu, Xugang1, Yao, Kang2, Jiang, Min1, Deng, Zeyuan1
Source: Journal of Food Science (John Wiley & Sons, Inc.). Feb2017, Vol. 82 Issue 2, p562-567. 6p.
Subjects: Tryptophan, Intestinal development, Physiological effects of amino acids, Tight junctions, Occludins, Swine physiology
Abstract (English): Dietary amino acids provide various beneficial effects for our health. The aim of the present study was to assess the effects of tryptophan (Trp) supplementation on barrier function. Ninety-six healthy finishing pigs (initial body weight 51.49 ± 1.12 kg) were randomly allocated into 2 treatment groups, control group, and 0.2% Trp group. The control group was fed the basal diet, and 0.2% Trp group was fed basal diet plus 0.2% Trp. The trial period is 60 d. Compared with control group, the mRNA abundance of claudin-3 and zonula occluden-1 (ZO-1) in the jejunum in 0.2% Trp group ( P < 0.05) was increased. According to immunohistochemistry and immunoblotting test, the expression of ZO-1 in jejunum in 0.2% Trp group was also significantly increased compared with the control group ( P < 0.05). These results revealed that Trp enhanced the expression of tight junction protein ZO-1 in the intestine of pig model. Trp may be potential and beneficial dietary functional factor for regulating the intestinal development and inhibiting intestinal aging. [ABSTRACT FROM AUTHOR]
Abstract (Portuguese): Practical Application The work has beneficial for intestinal health, such as promoting the gut development and inhibiting intestinal aging for the aged. The research has direct commercial application for amino acids supplementation or prebiotics. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Food Science (John Wiley & Sons, Inc.) is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 121183514
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Dietary Tryptophan Enhanced the Expression of Tight Junction Protein ZO-1 in Intestine.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Liu%2C+Wenhui%22&quot;&gt;Liu, Wenhui&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mi%2C+Shumei%22&quot;&gt;Mi, Shumei&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ruan%2C+Zheng%22&quot;&gt;Ruan, Zheng&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;i&gt; ruanzheng@ncu.edu.cn&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Li%2C+Jing%22&quot;&gt;Li, Jing&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shu%2C+Xugang%22&quot;&gt;Shu, Xugang&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yao%2C+Kang%22&quot;&gt;Yao, Kang&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jiang%2C+Min%22&quot;&gt;Jiang, Min&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Deng%2C+Zeyuan%22&quot;&gt;Deng, Zeyuan&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;
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– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Dietary amino acids provide various beneficial effects for our health. The aim of the present study was to assess the effects of tryptophan (Trp) supplementation on barrier function. Ninety-six healthy finishing pigs (initial body weight 51.49 &#177; 1.12 kg) were randomly allocated into 2 treatment groups, control group, and 0.2% Trp group. The control group was fed the basal diet, and 0.2% Trp group was fed basal diet plus 0.2% Trp. The trial period is 60 d. Compared with control group, the mRNA abundance of claudin-3 and zonula occluden-1 (ZO-1) in the jejunum in 0.2% Trp group ( P &lt; 0.05) was increased. According to immunohistochemistry and immunoblotting test, the expression of ZO-1 in jejunum in 0.2% Trp group was also significantly increased compared with the control group ( P &lt; 0.05). These results revealed that Trp enhanced the expression of tight junction protein ZO-1 in the intestine of pig model. Trp may be potential and beneficial dietary functional factor for regulating the intestinal development and inhibiting intestinal aging. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Portuguese)
  Group: Ab
  Data: Practical Application The work has beneficial for intestinal health, such as promoting the gut development and inhibiting intestinal aging for the aged. The research has direct commercial application for amino acids supplementation or prebiotics. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: &lt;i&gt;Copyright of Journal of Food Science (John Wiley &amp; Sons, Inc.) is the property of John Wiley &amp; Sons, Inc. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=121183514
RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1111/1750-3841.13603
    Languages:
      – Code: eng
        Text: English
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      Pagination:
        PageCount: 6
        StartPage: 562
    Subjects:
      – SubjectFull: Tryptophan
        Type: general
      – SubjectFull: Intestinal development
        Type: general
      – SubjectFull: Physiological effects of amino acids
        Type: general
      – SubjectFull: Tight junctions
        Type: general
      – SubjectFull: Occludins
        Type: general
      – SubjectFull: Swine physiology
        Type: general
    Titles:
      – TitleFull: Dietary Tryptophan Enhanced the Expression of Tight Junction Protein ZO-1 in Intestine.
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            NameFull: Liu, Wenhui
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            NameFull: Mi, Shumei
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            NameFull: Ruan, Zheng
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            NameFull: Li, Jing
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            NameFull: Shu, Xugang
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            NameFull: Yao, Kang
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              Text: Feb2017
              Type: published
              Y: 2017
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            – TitleFull: Journal of Food Science (John Wiley & Sons, Inc.)
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