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Association of ANRIL gene polymorphisms with major adverse cardiovascular events in hemodialysis patients.

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Title: Association of ANRIL gene polymorphisms with major adverse cardiovascular events in hemodialysis patients.
Authors: Arbiol-Roca, A1, Padró-Miquel, A1, Hueso, M2, Navarro, E3, Alía-Ramos, P1, González-Álvarez, MT2, Rama, I2, Torras, J2, Grinyó, JM2, Cruzado, JM2, Lloberas, N2 nlloberas@ub.edu
Source: Clinica Chimica Acta. Mar2017, Vol. 466, p61-67. 7p.
Subjects: Cardiovascular disease related mortality, Hemodialysis, Treatment of chronic kidney failure, Single nucleotide polymorphisms, Homozygosity
Abstract: Background Cardiovascular disease is the leading cause of death in patients with chronic kidney disease (CKD). Single nucleotide polymorphisms (SNPs) in ANRIL gene have been associated with higher cardiovascular morbidity and mortality in general population. The main objective was to ascertain whether ANRIL polymorphisms could identify risk of major adverse cardiovascular event (MACE) in patients starting on hemodialysis (HD). Methods This was a prospective observational cohort study. 284 CKD patients starting on HD were included in the study and followed until achievement of the primary end-point (MACE) or end of the study. All patients were genotyped for four ANRIL SNPs (rs10757278, rs4977574, rs10757274 and rs6475606). Kaplan-Meier curves and multivariate Cox survival analyses, together with multiple logistic regression were used to analyze the association between ANRIL SNPs and MACE. Results We found that ANRIL SNP rs10757278 was a representative SNP of a strong linkage disequilibrium block and showed significant genotypic associations with MACE in hemodialysis patients. Homozygous patients for the risk allele (GG) showed 2.17 (1.05–4.49) fold increased risk of MACE during hemodialysis than carriers of the protective allele (AA or AG). Diabetes mellitus was a strong enhancer of this effect. Conclusions Our results indicate that ANRIL polymorphisms may confer risk to development of MACE in incident patients on hemodialysis. [ABSTRACT FROM AUTHOR]
Copyright of Clinica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
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  Data: Association of ANRIL gene polymorphisms with major adverse cardiovascular events in hemodialysis patients.
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  Data: <searchLink fieldCode="AR" term="%22Arbiol-Roca%2C+A%22">Arbiol-Roca, A</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Padró-Miquel%2C+A%22">Padró-Miquel, A</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hueso%2C+M%22">Hueso, M</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Navarro%2C+E%22">Navarro, E</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Alía-Ramos%2C+P%22">Alía-Ramos, P</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22González-Álvarez%2C+MT%22">González-Álvarez, MT</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Rama%2C+I%22">Rama, I</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Torras%2C+J%22">Torras, J</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Grinyó%2C+JM%22">Grinyó, JM</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Cruzado%2C+JM%22">Cruzado, JM</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Lloberas%2C+N%22">Lloberas, N</searchLink><relatesTo>2</relatesTo><i> nlloberas@ub.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22Clinica+Chimica+Acta%22">Clinica Chimica Acta</searchLink>. Mar2017, Vol. 466, p61-67. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Cardiovascular+disease+related+mortality%22">Cardiovascular disease related mortality</searchLink><br /><searchLink fieldCode="DE" term="%22Hemodialysis%22">Hemodialysis</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+of+chronic+kidney+failure%22">Treatment of chronic kidney failure</searchLink><br /><searchLink fieldCode="DE" term="%22Single+nucleotide+polymorphisms%22">Single nucleotide polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Homozygosity%22">Homozygosity</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Background Cardiovascular disease is the leading cause of death in patients with chronic kidney disease (CKD). Single nucleotide polymorphisms (SNPs) in ANRIL gene have been associated with higher cardiovascular morbidity and mortality in general population. The main objective was to ascertain whether ANRIL polymorphisms could identify risk of major adverse cardiovascular event (MACE) in patients starting on hemodialysis (HD). Methods This was a prospective observational cohort study. 284 CKD patients starting on HD were included in the study and followed until achievement of the primary end-point (MACE) or end of the study. All patients were genotyped for four ANRIL SNPs (rs10757278, rs4977574, rs10757274 and rs6475606). Kaplan-Meier curves and multivariate Cox survival analyses, together with multiple logistic regression were used to analyze the association between ANRIL SNPs and MACE. Results We found that ANRIL SNP rs10757278 was a representative SNP of a strong linkage disequilibrium block and showed significant genotypic associations with MACE in hemodialysis patients. Homozygous patients for the risk allele (GG) showed 2.17 (1.05–4.49) fold increased risk of MACE during hemodialysis than carriers of the protective allele (AA or AG). Diabetes mellitus was a strong enhancer of this effect. Conclusions Our results indicate that ANRIL polymorphisms may confer risk to development of MACE in incident patients on hemodialysis. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Clinica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.cca.2016.12.029
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        Text: English
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      – SubjectFull: Cardiovascular disease related mortality
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      – SubjectFull: Hemodialysis
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      – SubjectFull: Treatment of chronic kidney failure
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      – SubjectFull: Single nucleotide polymorphisms
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