Ultrasound-assisted dispersive liquid-liquid microextraction for the determination of seven recreational drugs in human whole blood using gas chromatography–mass spectrometry.
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| Title: | Ultrasound-assisted dispersive liquid-liquid microextraction for the determination of seven recreational drugs in human whole blood using gas chromatography–mass spectrometry. |
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| Authors: | Lin, Zebin1, Li, Jiaolun1, Zhang, Xinyu1,2, Qiu, Meihong3, Huang, Zhibin1, Rao, Yulan1 yulan_rao@fudan.edu.cn |
| Source: | Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences. Mar2017, Vol. 1046, p177-184. 8p. |
| Subjects: | Liquid-liquid extraction, Drugs of abuse, Blood testing, Gas chromatography/Mass spectrometry (GC-MS), Amphetamines |
| Abstract: | Recreational drugs have large impact on public health and security, and to monitor them is of urgent demand. In the present study, ultrasound-assisted dispersive liquid-liquid microextraction combined with the detection of gas chromatography-mass spectrometry was applied to the determination of seven common recreational drugs, including amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, meperidine, methadone and ketamine in 200 μL of human whole blood. A series of factors which would affect the extraction efficiency were systematically investigated, including the nature and the volume of extraction and dispersing solvents, ultrasonication time, salting-out effect and pH value. The method consumed small amount of sample. The limits of detection and limits of quantification for each analyte were 10 and 40 ng/mL, respectively, and the linearity was in the range of 0.04–25 μg/mL (R 2 higher than 0.99). Good specificity, precision (1.5–8.2% for the intra-day study and 2.6–12.8% for the inter-day study), satisfactory accuracy (85.0–117.1%) and extraction recovery (77.0–92.4%) were obtained, which makes it a high performance method for the determination of recreational drugs in human whole blood samples. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 121360062 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Ultrasound-assisted dispersive liquid-liquid microextraction for the determination of seven recreational drugs in human whole blood using gas chromatography–mass spectrometry. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Lin%2C+Zebin%22">Lin, Zebin</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Li%2C+Jiaolun%22">Li, Jiaolun</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Xinyu%22">Zhang, Xinyu</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Qiu%2C+Meihong%22">Qiu, Meihong</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Huang%2C+Zhibin%22">Huang, Zhibin</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Rao%2C+Yulan%22">Rao, Yulan</searchLink><relatesTo>1</relatesTo><i> yulan_rao@fudan.edu.cn</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Chromatography+B%3A+Analytical+Technologies+in+the+Biomedical+%26+Life+Sciences%22">Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences</searchLink>. Mar2017, Vol. 1046, p177-184. 8p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Liquid-liquid+extraction%22">Liquid-liquid extraction</searchLink><br /><searchLink fieldCode="DE" term="%22Drugs+of+abuse%22">Drugs of abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+testing%22">Blood testing</searchLink><br /><searchLink fieldCode="DE" term="%22Gas+chromatography%2FMass+spectrometry+%28GC-MS%29%22">Gas chromatography/Mass spectrometry (GC-MS)</searchLink><br /><searchLink fieldCode="DE" term="%22Amphetamines%22">Amphetamines</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Recreational drugs have large impact on public health and security, and to monitor them is of urgent demand. In the present study, ultrasound-assisted dispersive liquid-liquid microextraction combined with the detection of gas chromatography-mass spectrometry was applied to the determination of seven common recreational drugs, including amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, meperidine, methadone and ketamine in 200 μL of human whole blood. A series of factors which would affect the extraction efficiency were systematically investigated, including the nature and the volume of extraction and dispersing solvents, ultrasonication time, salting-out effect and pH value. The method consumed small amount of sample. The limits of detection and limits of quantification for each analyte were 10 and 40 ng/mL, respectively, and the linearity was in the range of 0.04–25 μg/mL (R 2 higher than 0.99). Good specificity, precision (1.5–8.2% for the intra-day study and 2.6–12.8% for the inter-day study), satisfactory accuracy (85.0–117.1%) and extraction recovery (77.0–92.4%) were obtained, which makes it a high performance method for the determination of recreational drugs in human whole blood samples. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.jchromb.2017.01.024 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 177 Subjects: – SubjectFull: Liquid-liquid extraction Type: general – SubjectFull: Drugs of abuse Type: general – SubjectFull: Blood testing Type: general – SubjectFull: Gas chromatography/Mass spectrometry (GC-MS) Type: general – SubjectFull: Amphetamines Type: general Titles: – TitleFull: Ultrasound-assisted dispersive liquid-liquid microextraction for the determination of seven recreational drugs in human whole blood using gas chromatography–mass spectrometry. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lin, Zebin – PersonEntity: Name: NameFull: Li, Jiaolun – PersonEntity: Name: NameFull: Zhang, Xinyu – PersonEntity: Name: NameFull: Qiu, Meihong – PersonEntity: Name: NameFull: Huang, Zhibin – PersonEntity: Name: NameFull: Rao, Yulan IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2017 Type: published Y: 2017 Identifiers: – Type: issn-print Value: 15700232 Numbering: – Type: volume Value: 1046 Titles: – TitleFull: Journal of Chromatography B: Analytical Technologies in the Biomedical & Life Sciences Type: main |
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