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Evaluation of the characteristics of some plant polyphenols as molecules intercepting mitoxantrone.

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Title: Evaluation of the characteristics of some plant polyphenols as molecules intercepting mitoxantrone.
Authors: Osowski, Adam1, Kasparek, Adam1, Wieczorek, Zbigniew1, Amarowicz, Ryszard2, Szabelski, Mariusz1 mariusz.szabelski@uwm.edu.pl
Source: Food Chemistry. Jul2017, Vol. 227, p142-148. 7p.
Subjects: Plant polyphenols, Mitoxantrone, Quercetin, Clathrate compounds, Antineoplastic agents
Abstract: This paper contains the results of a study on the interactions between mitoxantrone and some bioactive polyphenols. It has been demonstrated that polyphenols can intercept mitoxantrone. Quercetin shows the highest affinity for complexing with mitoxantrone, in contrast to resveratrol, which shows the lowest affinity. The main process underlying the association between cytostatic and polyphenols occurs in the ground state. The values of the constants of the association reactions between the analysed compounds and mitoxantrone are large enough to generate an evident intercepting effect in the three-component system (mitoxantrone-DNA-polyphenol). The affinity of the analysed plant-origin compounds is approximately 1000-fold weaker than the interaction of mitoxantrone with the DNA, which implies that the presence of these compounds in food should not adversely affect oncological therapy but rather could successfully aid oncological treatment by regulating the quantities of the drug in its active form. [ABSTRACT FROM AUTHOR]
Copyright of Food Chemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Evaluation of the characteristics of some plant polyphenols as molecules intercepting mitoxantrone.
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  Data: <searchLink fieldCode="AR" term="%22Osowski%2C+Adam%22">Osowski, Adam</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kasparek%2C+Adam%22">Kasparek, Adam</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Wieczorek%2C+Zbigniew%22">Wieczorek, Zbigniew</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Amarowicz%2C+Ryszard%22">Amarowicz, Ryszard</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Szabelski%2C+Mariusz%22">Szabelski, Mariusz</searchLink><relatesTo>1</relatesTo><i> mariusz.szabelski@uwm.edu.pl</i>
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  Data: <searchLink fieldCode="JN" term="%22Food+Chemistry%22">Food Chemistry</searchLink>. Jul2017, Vol. 227, p142-148. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Plant+polyphenols%22">Plant polyphenols</searchLink><br /><searchLink fieldCode="DE" term="%22Mitoxantrone%22">Mitoxantrone</searchLink><br /><searchLink fieldCode="DE" term="%22Quercetin%22">Quercetin</searchLink><br /><searchLink fieldCode="DE" term="%22Clathrate+compounds%22">Clathrate compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Antineoplastic+agents%22">Antineoplastic agents</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: This paper contains the results of a study on the interactions between mitoxantrone and some bioactive polyphenols. It has been demonstrated that polyphenols can intercept mitoxantrone. Quercetin shows the highest affinity for complexing with mitoxantrone, in contrast to resveratrol, which shows the lowest affinity. The main process underlying the association between cytostatic and polyphenols occurs in the ground state. The values of the constants of the association reactions between the analysed compounds and mitoxantrone are large enough to generate an evident intercepting effect in the three-component system (mitoxantrone-DNA-polyphenol). The affinity of the analysed plant-origin compounds is approximately 1000-fold weaker than the interaction of mitoxantrone with the DNA, which implies that the presence of these compounds in food should not adversely affect oncological therapy but rather could successfully aid oncological treatment by regulating the quantities of the drug in its active form. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Food Chemistry is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.foodchem.2017.01.083
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 7
        StartPage: 142
    Subjects:
      – SubjectFull: Plant polyphenols
        Type: general
      – SubjectFull: Mitoxantrone
        Type: general
      – SubjectFull: Quercetin
        Type: general
      – SubjectFull: Clathrate compounds
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      – SubjectFull: Antineoplastic agents
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              Text: Jul2017
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