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The Impact of Intensity Modulated Radiation Therapy on Hospitalization Outcomes in the SEER-Medicare Population With Anal Squamous Cell Carcinoma.

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Title: The Impact of Intensity Modulated Radiation Therapy on Hospitalization Outcomes in the SEER-Medicare Population With Anal Squamous Cell Carcinoma.
Authors: Pollom, Erqi L.1 erqiliu@stanford.edu, Wang, Guanying2, Harris, Jeremy P.1, Koong, Albert C.1, Bendavid, Eran3, Bhattacharya, Jay3, Chang, Daniel T.1
Source: International Journal of Radiation Oncology, Biology, Physics. May2017, Vol. 98 Issue 1, p177-185. 9p.
Subjects: Anal cancer, Anal cancer treatment, Squamous cell carcinoma, Intensity modulated radiotherapy, Hospital care, Cancer radiotherapy, Diagnosis, Confidence intervals, Reporting of diseases, Medicare, Multivariate analysis, Radiotherapy, Survival, Treatment effectiveness, Proportional hazards models, Retrospective studies, Anal tumors, Confounding variables
Geographic Terms: United States
Abstract: Purpose: We examined the impact of intensity modulated radiation therapy (IMRT) on hospitalization rates in the Surveillance, Epidemiology, and End Results (SEER)-Medicare population with anal squamous cell carcinoma (SCC).Methods and Materials: We performed a retrospective cohort study using the SEER-Medicare database. We identified patients with nonmetastatic anal SCC diagnosed between 2001 and 2011 and treated with chemoradiation therapy. We assessed the relation between IMRT and first hospitalization by use of a multivariate competing-risk model, as well as instrumental variable analysis, using provider IMRT affinity as our instrument.Results: Of the 1165 patients included in our study, 458 (39%) received IMRT. IMRT use increased over time and was associated more with regional and provider characteristics than with patient characteristics. The 3- and 6-month cumulative incidences of first hospitalization were 41.9% (95% confidence interval [CI], 37.3%-46.4%) and 47.6% (95% CI, 43.0%-52.2%), respectively, for the IMRT cohort and 46.7% (95% CI, 43.0%-50.4%) and 52.1% (95% CI, 48.4%-55.7%), respectively, for the non-IMRT cohort. IMRT was associated with a decreased hazard of first hospitalization compared with 3-dimensional radiation techniques (hazard ratio, 0.70; 95% CI, 0.58-0.84; P=.0002). Instrumental variable analysis suggested an even greater reduction in hospitalizations with IMRT after controlling for unmeasured confounders. There was a trend toward improved overall survival with IMRT, with an adjusted hazard ratio of 0.77 (95% CI, 0.59-1.00; P=.05).Conclusions: The use of IMRT is associated with reduced hospitalizations in elderly patients with anal SCC. Further work is warranted to understand the long-term health and cost impact of IMRT, particularly for patient subgroups most at risk of toxicity and hospitalization. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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PubTypeId: academicJournal
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  Data: The Impact of Intensity Modulated Radiation Therapy on Hospitalization Outcomes in the SEER-Medicare Population With Anal Squamous Cell Carcinoma.
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  Data: <searchLink fieldCode="AR" term="%22Pollom%2C+Erqi+L%2E%22">Pollom, Erqi L.</searchLink><relatesTo>1</relatesTo><i> erqiliu@stanford.edu</i><br /><searchLink fieldCode="AR" term="%22Wang%2C+Guanying%22">Wang, Guanying</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Harris%2C+Jeremy+P%2E%22">Harris, Jeremy P.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Koong%2C+Albert+C%2E%22">Koong, Albert C.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Bendavid%2C+Eran%22">Bendavid, Eran</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Bhattacharya%2C+Jay%22">Bhattacharya, Jay</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Chang%2C+Daniel+T%2E%22">Chang, Daniel T.</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Radiation+Oncology%2C+Biology%2C+Physics%22">International Journal of Radiation Oncology, Biology, Physics</searchLink>. May2017, Vol. 98 Issue 1, p177-185. 9p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Anal+cancer%22">Anal cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Anal+cancer+treatment%22">Anal cancer treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Squamous+cell+carcinoma%22">Squamous cell carcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22Intensity+modulated+radiotherapy%22">Intensity modulated radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Hospital+care%22">Hospital care</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+radiotherapy%22">Cancer radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis%22">Diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Reporting+of+diseases%22">Reporting of diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Medicare%22">Medicare</searchLink><br /><searchLink fieldCode="DE" term="%22Multivariate+analysis%22">Multivariate analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Radiotherapy%22">Radiotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Survival%22">Survival</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Proportional+hazards+models%22">Proportional hazards models</searchLink><br /><searchLink fieldCode="DE" term="%22Retrospective+studies%22">Retrospective studies</searchLink><br /><searchLink fieldCode="DE" term="%22Anal+tumors%22">Anal tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Confounding+variables%22">Confounding variables</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22United+States%22">United States</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: <bold>Purpose: </bold>We examined the impact of intensity modulated radiation therapy (IMRT) on hospitalization rates in the Surveillance, Epidemiology, and End Results (SEER)-Medicare population with anal squamous cell carcinoma (SCC).<bold>Methods and Materials: </bold>We performed a retrospective cohort study using the SEER-Medicare database. We identified patients with nonmetastatic anal SCC diagnosed between 2001 and 2011 and treated with chemoradiation therapy. We assessed the relation between IMRT and first hospitalization by use of a multivariate competing-risk model, as well as instrumental variable analysis, using provider IMRT affinity as our instrument.<bold>Results: </bold>Of the 1165 patients included in our study, 458 (39%) received IMRT. IMRT use increased over time and was associated more with regional and provider characteristics than with patient characteristics. The 3- and 6-month cumulative incidences of first hospitalization were 41.9% (95% confidence interval [CI], 37.3%-46.4%) and 47.6% (95% CI, 43.0%-52.2%), respectively, for the IMRT cohort and 46.7% (95% CI, 43.0%-50.4%) and 52.1% (95% CI, 48.4%-55.7%), respectively, for the non-IMRT cohort. IMRT was associated with a decreased hazard of first hospitalization compared with 3-dimensional radiation techniques (hazard ratio, 0.70; 95% CI, 0.58-0.84; P=.0002). Instrumental variable analysis suggested an even greater reduction in hospitalizations with IMRT after controlling for unmeasured confounders. There was a trend toward improved overall survival with IMRT, with an adjusted hazard ratio of 0.77 (95% CI, 0.59-1.00; P=.05).<bold>Conclusions: </bold>The use of IMRT is associated with reduced hospitalizations in elderly patients with anal SCC. Further work is warranted to understand the long-term health and cost impact of IMRT, particularly for patient subgroups most at risk of toxicity and hospitalization. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Radiation Oncology, Biology, Physics is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1016/j.ijrobp.2017.01.006
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      – Code: eng
        Text: English
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        PageCount: 9
        StartPage: 177
    Subjects:
      – SubjectFull: Anal cancer
        Type: general
      – SubjectFull: Anal cancer treatment
        Type: general
      – SubjectFull: Squamous cell carcinoma
        Type: general
      – SubjectFull: Intensity modulated radiotherapy
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      – SubjectFull: Hospital care
        Type: general
      – SubjectFull: Cancer radiotherapy
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      – SubjectFull: Diagnosis
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Reporting of diseases
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      – SubjectFull: Medicare
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      – SubjectFull: Multivariate analysis
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      – SubjectFull: Radiotherapy
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      – SubjectFull: Survival
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      – SubjectFull: Treatment effectiveness
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      – SubjectFull: Proportional hazards models
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      – SubjectFull: Retrospective studies
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      – SubjectFull: Anal tumors
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      – SubjectFull: Confounding variables
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      – SubjectFull: United States
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      – TitleFull: The Impact of Intensity Modulated Radiation Therapy on Hospitalization Outcomes in the SEER-Medicare Population With Anal Squamous Cell Carcinoma.
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              Text: May2017
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