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Enhanced mechanical properties and biocompatibility of novel hydroxyapatite/TOPAS hybrid composite for bone tissue engineering applications.

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Title: Enhanced mechanical properties and biocompatibility of novel hydroxyapatite/TOPAS hybrid composite for bone tissue engineering applications.
Authors: Ain, Qurat Ul1, Khan, Ahmad Nawaz1 ahmad.nawaz@scme.nust.edu.pk, Nabavinia, Mahboubeh2, Mujahid, Mohammad1
Source: Materials Science & Engineering: C. Jun2017, Vol. 75, p807-815. 9p.
Subjects: Hydroxyapatite, Biocompatibility, Tissue engineering, Bone regeneration, Copolymers, Sodium dodecyl sulfate
Abstract: The bioactivity and mechanical properties of hybrid composites of hydroxyapatite (HA) in cyclic olefinic copolymer (COC) also known commercially as TOPAS are investigated, first time, for regeneration and repair of the bone tissues. HA is synthesized to obtain the spherically shaped nanoparticles in the size range of 60 ± 20 nm. Various concentrations of HA ranging from 1 to 30 wt% are dispersed in TOPAS using sodium dodecyl sulfate (SDS) coupling agent for better dispersion and interaction of hydrophilic HA with hydrophobic TOPAS. Scanning electron microscope shows the uniform dispersion of HA ≤ 10 wt% in TOPAS and at higher concentrations > 10 wt%, agglomeration occurs in the hybrid composites. Tunable mechanical properties are achieved as the compressive modulus and strength are increased around 140% from 6.4 to 15.3 MPa and 185% from 0.26 to 0.74 MPa, respectively. Such increase in the mechanical properties of TOPAS is attributed to the anchoring of the polymer chains in the vicinity of HA nanoparticles owing to better dispersion and interfacial interactions. In comparison to neat TOPAS, hybrid composites of TOPAS/HA promoted the cell adhesion and proliferation significantly. The cell density and proliferation of TOPAS/HA hybrid composites is enhanced 9 and 3 folds, respectively, after 1 day culturing in preosteoblasts cells. Moreover, the morphology of cells changed from spherical to flattened spread morphology demonstrating clearly the migration of the cells for the formation of interconnected cellular network. Additionally, very few dead cells are found in hybrid composites showing their cytocompatibility. Overall, the hybrid composites of TOPAS/HA exhibited superior strength and stiffness along with enhanced cytocompatibility for bone tissue engineering applications. [ABSTRACT FROM AUTHOR]
Copyright of Materials Science & Engineering: C is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 122478277
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Enhanced mechanical properties and biocompatibility of novel hydroxyapatite/TOPAS hybrid composite for bone tissue engineering applications.
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  Data: <searchLink fieldCode="AR" term="%22Ain%2C+Qurat+Ul%22">Ain, Qurat Ul</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Khan%2C+Ahmad+Nawaz%22">Khan, Ahmad Nawaz</searchLink><relatesTo>1</relatesTo><i> ahmad.nawaz@scme.nust.edu.pk</i><br /><searchLink fieldCode="AR" term="%22Nabavinia%2C+Mahboubeh%22">Nabavinia, Mahboubeh</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Mujahid%2C+Mohammad%22">Mujahid, Mohammad</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Materials+Science+%26+Engineering%3A+C%22">Materials Science & Engineering: C</searchLink>. Jun2017, Vol. 75, p807-815. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Hydroxyapatite%22">Hydroxyapatite</searchLink><br /><searchLink fieldCode="DE" term="%22Biocompatibility%22">Biocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22Tissue+engineering%22">Tissue engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Bone+regeneration%22">Bone regeneration</searchLink><br /><searchLink fieldCode="DE" term="%22Copolymers%22">Copolymers</searchLink><br /><searchLink fieldCode="DE" term="%22Sodium+dodecyl+sulfate%22">Sodium dodecyl sulfate</searchLink>
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  Label: Abstract
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  Data: The bioactivity and mechanical properties of hybrid composites of hydroxyapatite (HA) in cyclic olefinic copolymer (COC) also known commercially as TOPAS are investigated, first time, for regeneration and repair of the bone tissues. HA is synthesized to obtain the spherically shaped nanoparticles in the size range of 60 ± 20 nm. Various concentrations of HA ranging from 1 to 30 wt% are dispersed in TOPAS using sodium dodecyl sulfate (SDS) coupling agent for better dispersion and interaction of hydrophilic HA with hydrophobic TOPAS. Scanning electron microscope shows the uniform dispersion of HA ≤ 10 wt% in TOPAS and at higher concentrations > 10 wt%, agglomeration occurs in the hybrid composites. Tunable mechanical properties are achieved as the compressive modulus and strength are increased around 140% from 6.4 to 15.3 MPa and 185% from 0.26 to 0.74 MPa, respectively. Such increase in the mechanical properties of TOPAS is attributed to the anchoring of the polymer chains in the vicinity of HA nanoparticles owing to better dispersion and interfacial interactions. In comparison to neat TOPAS, hybrid composites of TOPAS/HA promoted the cell adhesion and proliferation significantly. The cell density and proliferation of TOPAS/HA hybrid composites is enhanced 9 and 3 folds, respectively, after 1 day culturing in preosteoblasts cells. Moreover, the morphology of cells changed from spherical to flattened spread morphology demonstrating clearly the migration of the cells for the formation of interconnected cellular network. Additionally, very few dead cells are found in hybrid composites showing their cytocompatibility. Overall, the hybrid composites of TOPAS/HA exhibited superior strength and stiffness along with enhanced cytocompatibility for bone tissue engineering applications. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Materials Science & Engineering: C is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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        Value: 10.1016/j.msec.2017.02.117
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      – Code: eng
        Text: English
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        PageCount: 9
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    Subjects:
      – SubjectFull: Hydroxyapatite
        Type: general
      – SubjectFull: Biocompatibility
        Type: general
      – SubjectFull: Tissue engineering
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      – SubjectFull: Bone regeneration
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      – SubjectFull: Copolymers
        Type: general
      – SubjectFull: Sodium dodecyl sulfate
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      – TitleFull: Enhanced mechanical properties and biocompatibility of novel hydroxyapatite/TOPAS hybrid composite for bone tissue engineering applications.
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            NameFull: Ain, Qurat Ul
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            NameFull: Khan, Ahmad Nawaz
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            NameFull: Nabavinia, Mahboubeh
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            NameFull: Mujahid, Mohammad
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            – D: 01
              M: 06
              Text: Jun2017
              Type: published
              Y: 2017
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