Empirical model of human blood transverse relaxation at 3 T improves MRI T2 oximetry.
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| Title: | Empirical model of human blood transverse relaxation at 3 T improves MRI T |
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| Authors: | Bush, Adam1,2, Borzage, Matthew3,4, Detterich, John1, Kato, Roberta M.5, Meiselman, Herbert J.6, Coates, Thomas7, Wood, John C.1,2 jwood@chla.usc |
| Source: | Magnetic Resonance in Medicine. Jun2017, Vol. 77 Issue 6, p2364-2371. 8p. |
| Abstract: | Purpose We sought a human blood T2-oximetery calibration curve over the wide range of hematocrits commonly found in anemic patients applicable with T2 relaxation under spin tagging (TRUST). Methods Blood was drawn from five healthy control subjects. Ninety-three in vitro blood transverse relaxation (T2b) measurements were performed at 37°C over a broad range of hematocrits (10-55%) and oxygen saturations (14-100%) at 3 Tesla (T). In vivo TRUST was performed on 35 healthy African American control subjects and 11 patients with chronic anemia syndromes. Results 1/T2 rose linearly with hematocrit (r2 = 0.96), for fully saturated blood. Upon desaturation, 1/T2 rose linearly with the square of the oxygen extraction, (1-Y)2, and the slope was linearly proportional to hematocrit (r2 = 0.88). The resulting bilinear model between 1/T2, (1-Y)2, and hematocrit had a combined r2 of 0.96 and a coefficient of variation of 6.1%. Using the in vivo data, the bilinear model had significantly lower bias and variability than existing calibrations, particularly for low hematocrits. In vivo Bland Altman analysis demonstrated clinically relevant bias that was [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Header | DbId: egs DbLabel: Engineering Source An: 123050810 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Empirical model of human blood transverse relaxation at 3 T improves MRI T<subscript>2</subscript> oximetry. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Bush%2C+Adam%22">Bush, Adam</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Borzage%2C+Matthew%22">Borzage, Matthew</searchLink><relatesTo>3,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Detterich%2C+John%22">Detterich, John</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kato%2C+Roberta+M%2E%22">Kato, Roberta M.</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Meiselman%2C+Herbert+J%2E%22">Meiselman, Herbert J.</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Coates%2C+Thomas%22">Coates, Thomas</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Wood%2C+John+C%2E%22">Wood, John C.</searchLink><relatesTo>1,2</relatesTo><i> jwood@chla.usc</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Jun2017, Vol. 77 Issue 6, p2364-2371. 8p. – Name: Abstract Label: Abstract Group: Ab Data: Purpose We sought a human blood T2-oximetery calibration curve over the wide range of hematocrits commonly found in anemic patients applicable with T2 relaxation under spin tagging (TRUST). Methods Blood was drawn from five healthy control subjects. Ninety-three in vitro blood transverse relaxation (T2b) measurements were performed at 37°C over a broad range of hematocrits (10-55%) and oxygen saturations (14-100%) at 3 Tesla (T). In vivo TRUST was performed on 35 healthy African American control subjects and 11 patients with chronic anemia syndromes. Results 1/T2 rose linearly with hematocrit (r2 = 0.96), for fully saturated blood. Upon desaturation, 1/T2 rose linearly with the square of the oxygen extraction, (1-Y)2, and the slope was linearly proportional to hematocrit (r2 = 0.88). The resulting bilinear model between 1/T2, (1-Y)2, and hematocrit had a combined r2 of 0.96 and a coefficient of variation of 6.1%. Using the in vivo data, the bilinear model had significantly lower bias and variability than existing calibrations, particularly for low hematocrits. In vivo Bland Altman analysis demonstrated clinically relevant bias that was [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.26311 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 2364 Titles: – TitleFull: Empirical model of human blood transverse relaxation at 3 T improves MRI T2 oximetry. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bush, Adam – PersonEntity: Name: NameFull: Borzage, Matthew – PersonEntity: Name: NameFull: Detterich, John – PersonEntity: Name: NameFull: Kato, Roberta M. – PersonEntity: Name: NameFull: Meiselman, Herbert J. – PersonEntity: Name: NameFull: Coates, Thomas – PersonEntity: Name: NameFull: Wood, John C. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2017 Type: published Y: 2017 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 77 – Type: issue Value: 6 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
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