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Subharmonic-Aided Pressure Estimation for Monitoring Interstitial Fluid Pressure in Tumors: Calibration and Treatment with Paclitaxel in Breast Cancer Xenografts.

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Title: Subharmonic-Aided Pressure Estimation for Monitoring Interstitial Fluid Pressure in Tumors: Calibration and Treatment with Paclitaxel in Breast Cancer Xenografts.
Authors: Halldorsdottir, Valgerdur G.1,2, Dave, Jaydev K.1, Marshall, Andrew1,2, Forsberg, Anya I.3, Fox, Traci B.4, Eisenbrey, John R.1, Machado, Priscilla1, Liu, Ji-Bin1, Merton, Daniel A.1, Forsberg, Flemming1 flemming.forsberg@jefferson.edu
Source: Ultrasound in Medicine & Biology. Jul2017, Vol. 43 Issue 7, p1401-1410. 10p.
Subjects: Breast cancer treatment, Fluid pressure, Paclitaxel, Calibration, Xenografts, Manometers, Animal experimentation, Antineoplastic agents, Breast tumors, Cell lines, Diagnostic imaging, Drug monitoring, Computers in medicine, Extracellular fluid, Pressure, Rats, Research evaluation, Research funding, Ultrasonic imaging, Treatment effectiveness, Physiology, Equipment & supplies
Abstract: Interstitial fluid pressure (IFP) in rats with breast cancer xenografts was non-invasively estimated using subharmonic-aided pressure estimation (SHAPE) versus an invasive pressure monitor. Moreover, monitoring of IFP changes after chemotherapy was assessed. Eighty-nine rats (calibration n = 25, treatment n = 64) were injected with 5 × 106 breast cancer cells (MDA-MB-231). Radiofrequency signals were acquired (39 rats successfully imaged) with a Sonix RP scanner (BK Ultrasound, Richmond, BC, Canada) using a linear array (L9-4, transmit/receive: 8/4 MHz) after administration of Definity (Lantheus Medical Imaging, North Billerica, MA, USA; 180 μL/kg) and compared with readings from an invasive pressure monitor (Stryker, Berkshire, UK). An inverse linear relationship was established between tumor IFP and SHAPE (y = -1.06x + 28.27, r = -0.69, p = 0.01) in the calibration group. Use of this relationship in the treatment group resulted in r = 0.74 (p < 0.05) between measured (pressure monitor) and SHAPE-estimated IFP (average error: 6.24 mmHg). No significant before/after differences were observed with respect to paclitaxel treatment (5 mg/kg, Mayne Pharma, Paramus, NJ, USA) with either method (p ≥ 0.15). [ABSTRACT FROM AUTHOR]
Copyright of Ultrasound in Medicine & Biology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Subharmonic-Aided Pressure Estimation for Monitoring Interstitial Fluid Pressure in Tumors: Calibration and Treatment with Paclitaxel in Breast Cancer Xenografts.
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  Data: Interstitial fluid pressure (IFP) in rats with breast cancer xenografts was non-invasively estimated using subharmonic-aided pressure estimation (SHAPE) versus an invasive pressure monitor. Moreover, monitoring of IFP changes after chemotherapy was assessed. Eighty-nine rats (calibration n&#160;=&#160;25, treatment n&#160;=&#160;64) were injected with 5&#160;&#215;&#160;106 breast cancer cells (MDA-MB-231). Radiofrequency signals were acquired (39 rats successfully imaged) with a Sonix RP scanner (BK Ultrasound, Richmond, BC, Canada) using a linear array (L9-4, transmit/receive: 8/4&#160;MHz) after administration of Definity (Lantheus Medical Imaging, North Billerica, MA, USA; 180&#160;μL/kg) and compared with readings from an invasive pressure monitor (Stryker, Berkshire, UK). An inverse linear relationship was established between tumor IFP and SHAPE (y&#160;=&#160;-1.06x&#160;+&#160;28.27, r&#160;=&#160;-0.69, p&#160;=&#160;0.01) in the calibration group. Use of this relationship in the treatment group resulted in r&#160;=&#160;0.74 (p&#160;&lt;&#160;0.05) between measured (pressure monitor) and SHAPE-estimated IFP (average error: 6.24&#160;mmHg). No significant before/after differences were observed with respect to paclitaxel treatment (5&#160;mg/kg, Mayne Pharma, Paramus, NJ, USA) with either method (p&#160;≥&#160;0.15). [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Ultrasound in Medicine &amp; Biology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.ultrasmedbio.2017.02.011
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      – Code: eng
        Text: English
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        Type: general
      – SubjectFull: Fluid pressure
        Type: general
      – SubjectFull: Paclitaxel
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      – SubjectFull: Calibration
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      – SubjectFull: Xenografts
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      – SubjectFull: Manometers
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      – SubjectFull: Animal experimentation
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      – SubjectFull: Antineoplastic agents
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      – SubjectFull: Breast tumors
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      – SubjectFull: Cell lines
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      – SubjectFull: Diagnostic imaging
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      – SubjectFull: Drug monitoring
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      – SubjectFull: Computers in medicine
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      – SubjectFull: Extracellular fluid
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      – SubjectFull: Pressure
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      – SubjectFull: Rats
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