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Development of surface imprinted nanospheres using the inverse suspension polymerization method for electrochemical ultra sensing of dacarbazine.

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Title: Development of surface imprinted nanospheres using the inverse suspension polymerization method for electrochemical ultra sensing of dacarbazine.
Authors: Prasad, Bhim Bali1 prof.bbpd@yahoo.com, Pathak, Purnendu Kumar1
Source: Analytica Chimica Acta. Jun2017, Vol. 974, p75-86. 12p.
Subjects: Nanoparticles, Polymerization, Dacarbazine, Suspensions (Chemistry), Electrochemical sensors, Electron transport
Abstract: A new ultra sensing molecularly imprinted polymer beads modified pencil graphite electrode was fabricated, with the help of the inverse suspension polymerization technique, for ascertaining the adequate supplementation of dacarbazine in the cancer treatment. The inverse suspension polymerization technique was beneficial in obtaining surface imprinted polymer-based electrocatalytic nanospheres with narrow size distribution. These nanospheres were found to be superior to the corresponding microspheres and planar films, in terms of electrode kinetics and sensitivity, with the differential pulse anodic stripping voltammetric transduction. Herein, multiwalled carbon nanotubes functionalized ester links were invoked in between the imprinted nanospheres and the pencil graphite electrode surface to secure a stable coating and better electrodics. The proposed electrochemical sensor showed the imprinting factor and the analyte adsorption coefficient as high as 24.3 and 1.06 × 10 9 L mol −1 , respectively. Furthermore, 16-fold and 4-fold faster electron transfer kinetics were observed with the imprinted nanospheres than the corresponding imprinted planar film and the microspheres based electrodes, respectively. The limits of detection [0.02 (aqueous), 0.02 (plasma), 0.01 (urine), and 0.03 ng mL −1 (pharmaceutics), (3 σ , RSD ≤ 0.23%)] of dacarbazine, realized with the imprinted polymer nanospheres, were free from any cross-reactivity and false-positive complications in aqueous, blood plasma, urine, and pharmaceutical samples. [ABSTRACT FROM AUTHOR]
Copyright of Analytica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 123157334
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Label: Title
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  Data: Development of surface imprinted nanospheres using the inverse suspension polymerization method for electrochemical ultra sensing of dacarbazine.
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  Data: <searchLink fieldCode="AR" term="%22Prasad%2C+Bhim+Bali%22">Prasad, Bhim Bali</searchLink><relatesTo>1</relatesTo><i> prof.bbpd@yahoo.com</i><br /><searchLink fieldCode="AR" term="%22Pathak%2C+Purnendu+Kumar%22">Pathak, Purnendu Kumar</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Analytica+Chimica+Acta%22">Analytica Chimica Acta</searchLink>. Jun2017, Vol. 974, p75-86. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Nanoparticles%22">Nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Polymerization%22">Polymerization</searchLink><br /><searchLink fieldCode="DE" term="%22Dacarbazine%22">Dacarbazine</searchLink><br /><searchLink fieldCode="DE" term="%22Suspensions+%28Chemistry%29%22">Suspensions (Chemistry)</searchLink><br /><searchLink fieldCode="DE" term="%22Electrochemical+sensors%22">Electrochemical sensors</searchLink><br /><searchLink fieldCode="DE" term="%22Electron+transport%22">Electron transport</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: A new ultra sensing molecularly imprinted polymer beads modified pencil graphite electrode was fabricated, with the help of the inverse suspension polymerization technique, for ascertaining the adequate supplementation of dacarbazine in the cancer treatment. The inverse suspension polymerization technique was beneficial in obtaining surface imprinted polymer-based electrocatalytic nanospheres with narrow size distribution. These nanospheres were found to be superior to the corresponding microspheres and planar films, in terms of electrode kinetics and sensitivity, with the differential pulse anodic stripping voltammetric transduction. Herein, multiwalled carbon nanotubes functionalized ester links were invoked in between the imprinted nanospheres and the pencil graphite electrode surface to secure a stable coating and better electrodics. The proposed electrochemical sensor showed the imprinting factor and the analyte adsorption coefficient as high as 24.3 and 1.06 × 10 9 L mol −1 , respectively. Furthermore, 16-fold and 4-fold faster electron transfer kinetics were observed with the imprinted nanospheres than the corresponding imprinted planar film and the microspheres based electrodes, respectively. The limits of detection [0.02 (aqueous), 0.02 (plasma), 0.01 (urine), and 0.03 ng mL −1 (pharmaceutics), (3 σ , RSD ≤ 0.23%)] of dacarbazine, realized with the imprinted polymer nanospheres, were free from any cross-reactivity and false-positive complications in aqueous, blood plasma, urine, and pharmaceutical samples. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Analytica Chimica Acta is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.aca.2017.04.001
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      – Code: eng
        Text: English
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        PageCount: 12
        StartPage: 75
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      – SubjectFull: Nanoparticles
        Type: general
      – SubjectFull: Polymerization
        Type: general
      – SubjectFull: Dacarbazine
        Type: general
      – SubjectFull: Suspensions (Chemistry)
        Type: general
      – SubjectFull: Electrochemical sensors
        Type: general
      – SubjectFull: Electron transport
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              Text: Jun2017
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              Y: 2017
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