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Gd-EOB-DTPA-enhanced MRI for monitoring future liver remnant function after portal vein embolization and extended hemihepatectomy: A prospective trial.

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Title: Gd-EOB-DTPA-enhanced MRI for monitoring future liver remnant function after portal vein embolization and extended hemihepatectomy: A prospective trial.
Authors: Geisel, Dominik1 dominik.geisel@charite.de, Raabe, Philip1, Lüdemann, Lutz2, Malinowski, Maciej3, Stockmann, Martin3, Seehofer, Daniel3, Pratschke, Johann3, Hamm, Bernd1, Denecke, Timm1, Lüdemann, Lutz4 (AUTHOR)
Source: European Radiology. Jul2017, Vol. 27 Issue 7, p3080-3087. 8p. 1 Black and White Photograph, 1 Diagram, 2 Charts, 4 Graphs.
Subjects: Tumor treatment, Liver tumors, Liver injuries, Liver function tests, Liver, Hepatectomy, Therapeutic embolization, Diethylenetriaminepentaacetic acid, Gadolinium, Magnetic resonance imaging, Clinical trials, Comparative studies, Computed tomography, Longitudinal method, Research methodology, Medical cooperation, Patient monitoring, Portal vein, Research, Ultrasonic imaging, Evaluation research, Contrast media, Diagnosis
Abstract: Objectives: To evaluate changes in liver function after right portal vein embolization (PVE) and extended right hemihepatectomy using gadolinium ethoxybenzyl-DTPA-enhanced (Gd-EOB-DTPA) MRI.Methods: In this prospective trial, 37 patients undergoing PVE were examined before and 14 and 28 days after PVE and 10 days after extended hemihepatectomy using Gd-EOB-DTPA-enhanced MRI. Lobar volume, kinetic growth rate (KGR), relative enhancement (RE) as well as hepatocellular uptake index (HUI) and fat signal fraction (FSF) were calculated for each lobe.Results: RE of the left liver lobe (LLL) was steadily increasing after PVE and decreased to 0.48 ± 0.19 10 days after surgery, which is significantly lower than 14 days and 28 days post PVE (P < 0.05). KGR was 14.06 ± 9.82%/week for the period from PVE to 14 days after PVE. HUI of the LLL increased steadily after PVE and was significantly higher at both 14 and 28 days after PVE compared to pre PVE (P < 0.05). HUI of the residual liver after surgery was lower than before.Conclusions: Gd-EOB-DTPA-enhanced MRI may be used to monitor the functional increase in the FLR after PVE and to depict the intraoperative liver injury leading to a decrease in liver remnant function.Key Points: • The most significant FLR volume increase happens within the first 14 days. • No MRI parameter was able to predict the success of FLR growth. • Our data suggest an early resection about 14 days after PVE. • Routine Gd-EOB-DTPA-enhanced MRI might be suitable to replace ICG-test. [ABSTRACT FROM AUTHOR]
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Abstract:<bold>Objectives: </bold>To evaluate changes in liver function after right portal vein embolization (PVE) and extended right hemihepatectomy using gadolinium ethoxybenzyl-DTPA-enhanced (Gd-EOB-DTPA) MRI.<bold>Methods: </bold>In this prospective trial, 37 patients undergoing PVE were examined before and 14 and 28 days after PVE and 10 days after extended hemihepatectomy using Gd-EOB-DTPA-enhanced MRI. Lobar volume, kinetic growth rate (KGR), relative enhancement (RE) as well as hepatocellular uptake index (HUI) and fat signal fraction (FSF) were calculated for each lobe.<bold>Results: </bold>RE of the left liver lobe (LLL) was steadily increasing after PVE and decreased to 0.48 ± 0.19 10 days after surgery, which is significantly lower than 14 days and 28 days post PVE (P < 0.05). KGR was 14.06 ± 9.82%/week for the period from PVE to 14 days after PVE. HUI of the LLL increased steadily after PVE and was significantly higher at both 14 and 28 days after PVE compared to pre PVE (P < 0.05). HUI of the residual liver after surgery was lower than before.<bold>Conclusions: </bold>Gd-EOB-DTPA-enhanced MRI may be used to monitor the functional increase in the FLR after PVE and to depict the intraoperative liver injury leading to a decrease in liver remnant function.<bold>Key Points: </bold>• The most significant FLR volume increase happens within the first 14 days. • No MRI parameter was able to predict the success of FLR growth. • Our data suggest an early resection about 14 days after PVE. • Routine Gd-EOB-DTPA-enhanced MRI might be suitable to replace ICG-test. [ABSTRACT FROM AUTHOR]
ISSN:09387994
DOI:10.1007/s00330-016-4674-y