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Hepatosplenic volumetric assessment at MDCT for staging liver fibrosis.

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Title: Hepatosplenic volumetric assessment at MDCT for staging liver fibrosis.
Authors: Pickhardt, Perry1 ppickhardt2@uwhealth.org, Malecki, Kyle1, Hunt, Oliver1, Beaumont, Claire1, Kloke, John1, Ziemlewicz, Timothy1, Lubner, Meghan1, Pickhardt, Perry J2 (AUTHOR), Hunt, Oliver F2 (AUTHOR), Ziemlewicz, Timothy J2 (AUTHOR), Lubner, Meghan G2 (AUTHOR)
Source: European Radiology. Jul2017, Vol. 27 Issue 7, p3060-3068. 9p. 1 Diagram, 3 Charts, 3 Graphs.
Subjects: Hepatic fibrosis, Liver biopsy, Cirrhosis of the liver, Liver tumors, Multidetector computed tomography, Biomarkers, Volumetric analysis, Diagnosis
Abstract: Purpose: To investigate hepatosplenic volumetry at MDCT for non-invasive prediction of hepatic fibrosis.Methods: Hepatosplenic volume analysis in 624 patients (mean age, 48.8 years; 311 M/313 F) at MDCT was performed using dedicated software and compared against pathological fibrosis stage (F0 = 374; F1 = 48; F2 = 40; F3 = 65; F4 = 97). The liver segmental volume ratio (LSVR) was defined by Couinaud segments I-III over segments IV-VIII. All pre-cirrhotic fibrosis stages (METAVIR F1-F3) were based on liver biopsy within 1 year of MDCT.Results: LSVR and total splenic volumes increased with stage of fibrosis, with mean(±SD) values of: F0: 0.26 ± 0.06 and 215.1 ± 88.5 mm3; F1: 0.25 ± 0.08 and 294.8 ± 153.4 mm3; F2: 0.331 ± 0.12 and 291.6 ± 197.1 mm3; F3: 0.39 ± 0.15 and 509.6 ± 402.6 mm3; F4: 0.56 ± 0.30 and 790.7 ± 450.3 mm3, respectively. Total hepatic volumes showed poor discrimination (F0: 1674 ± 320 mm3; F4: 1631 ± 691 mm3). For discriminating advanced fibrosis (≥F3), the ROC AUC values for LSVR, total liver volume, splenic volume and LSVR/spleen combined were 0.863, 0.506, 0.890 and 0.947, respectively.Conclusion: Relative changes in segmental liver volumes and total splenic volume allow for non-invasive staging of hepatic fibrosis, whereas total liver volume is a poor predictor. Unlike liver biopsy or elastography, these CT volumetric biomarkers can be obtained retrospectively on routine scans obtained for other indications.Key Points: • Regional changes in hepatic volume (LSVR) correlate well with degree of fibrosis. • Total liver volume is a very poor predictor of underlying fibrosis. • Total splenic volume is associated with the degree of hepatic fibrosis. • Hepatosplenic volume assessment is comparable to elastography for staging fibrosis. • Unlike elastography, volumetric analysis can be performed retrospectively. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Hepatosplenic volumetric assessment at MDCT for staging liver fibrosis.
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  Data: <searchLink fieldCode="AR" term="%22Pickhardt%2C+Perry%22">Pickhardt, Perry</searchLink><relatesTo>1</relatesTo><i> ppickhardt2@uwhealth.org</i><br /><searchLink fieldCode="AR" term="%22Malecki%2C+Kyle%22">Malecki, Kyle</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hunt%2C+Oliver%22">Hunt, Oliver</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Beaumont%2C+Claire%22">Beaumont, Claire</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kloke%2C+John%22">Kloke, John</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ziemlewicz%2C+Timothy%22">Ziemlewicz, Timothy</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lubner%2C+Meghan%22">Lubner, Meghan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Pickhardt%2C+Perry+J%22">Pickhardt, Perry J</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hunt%2C+Oliver+F%22">Hunt, Oliver F</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ziemlewicz%2C+Timothy+J%22">Ziemlewicz, Timothy J</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lubner%2C+Meghan+G%22">Lubner, Meghan G</searchLink><relatesTo>2</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Jul2017, Vol. 27 Issue 7, p3060-3068. 9p. 1 Diagram, 3 Charts, 3 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Hepatic+fibrosis%22">Hepatic fibrosis</searchLink><br /><searchLink fieldCode="DE" term="%22Liver+biopsy%22">Liver biopsy</searchLink><br /><searchLink fieldCode="DE" term="%22Cirrhosis+of+the+liver%22">Cirrhosis of the liver</searchLink><br /><searchLink fieldCode="DE" term="%22Liver+tumors%22">Liver tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Multidetector+computed+tomography%22">Multidetector computed tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Volumetric+analysis%22">Volumetric analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis%22">Diagnosis</searchLink>
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  Data: <bold>Purpose: </bold>To investigate hepatosplenic volumetry at MDCT for non-invasive prediction of hepatic fibrosis.<bold>Methods: </bold>Hepatosplenic volume analysis in 624 patients (mean age, 48.8 years; 311 M/313 F) at MDCT was performed using dedicated software and compared against pathological fibrosis stage (F0 = 374; F1 = 48; F2 = 40; F3 = 65; F4 = 97). The liver segmental volume ratio (LSVR) was defined by Couinaud segments I-III over segments IV-VIII. All pre-cirrhotic fibrosis stages (METAVIR F1-F3) were based on liver biopsy within 1 year of MDCT.<bold>Results: </bold>LSVR and total splenic volumes increased with stage of fibrosis, with mean(±SD) values of: F0: 0.26 ± 0.06 and 215.1 ± 88.5 mm3; F1: 0.25 ± 0.08 and 294.8 ± 153.4 mm3; F2: 0.331 ± 0.12 and 291.6 ± 197.1 mm3; F3: 0.39 ± 0.15 and 509.6 ± 402.6 mm3; F4: 0.56 ± 0.30 and 790.7 ± 450.3 mm3, respectively. Total hepatic volumes showed poor discrimination (F0: 1674 ± 320 mm3; F4: 1631 ± 691 mm3). For discriminating advanced fibrosis (≥F3), the ROC AUC values for LSVR, total liver volume, splenic volume and LSVR/spleen combined were 0.863, 0.506, 0.890 and 0.947, respectively.<bold>Conclusion: </bold>Relative changes in segmental liver volumes and total splenic volume allow for non-invasive staging of hepatic fibrosis, whereas total liver volume is a poor predictor. Unlike liver biopsy or elastography, these CT volumetric biomarkers can be obtained retrospectively on routine scans obtained for other indications.<bold>Key Points: </bold>• Regional changes in hepatic volume (LSVR) correlate well with degree of fibrosis. • Total liver volume is a very poor predictor of underlying fibrosis. • Total splenic volume is associated with the degree of hepatic fibrosis. • Hepatosplenic volume assessment is comparable to elastography for staging fibrosis. • Unlike elastography, volumetric analysis can be performed retrospectively. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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